Realization and verification of three-dimensional conformal radiotherapy with modulated fields

Bortfeld, Thomas; Boyer, Arthur L.; Schlegel, Wolfgang; Kahler, Darren; Waldron, Timothy J.

doi:10.1016/0360-3016(94)90366-2

Cited by 203 publications

(85 citation statements)

References 23 publications

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“…[1][2][3][4][5][6][7][8][9][10][11][12][13] There are, however, many unanswered questions about this new method of treatment delivery. The goal of this project has been the development of a test environment that provides a means for efficiently investigating some of the unresolved issues in IMRT.…”

Section: Introductionmentioning

confidence: 99%

A simple model for examining issues in radiotherapy optimization

Shepard¹,

Olivera²,

Angelos³

et al. 1999

Medical Physics

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Convolution/superposition software has been used to produce a library of photon pencil beam dose matrices. This library of pencil beams is designed to serve as a tool for both education and investigation in the field of radiotherapy optimization. The elegance of this pencil beam model stems from its cylindrical symmetry. Because of the symmetry, the dose distribution for a pencil beam from any arbitrary angle can be determined through a simple rotation of a pre-computed dose matrix. Rapid dose calculations can thus be performed while maintaining the accuracy of a convolution/superposition based dose computation. The pencil beam data sets have been made publicly available. It is hoped that the data sets will facilitate a comparison of a variety of optimization and delivery approaches. This paper will present a number of studies designed to demonstrate the usefulness of the pencil beam data sets. These studies include an examination of the extent to which a treatment plan can be improved through either an increase in the number of beam angles and/or a decrease in the collimator size. A few insights into the significance of heterogeneity corrections for treatment planning for intensity modulated radiotherapy will also be presented.

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Section: Introductionmentioning

confidence: 99%

A simple model for examining issues in radiotherapy optimization

Shepard¹,

Olivera²,

Angelos³

et al. 1999

Medical Physics

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“…We followed DKFZ Heidelberg's verification procedure ͑''IMRT Workshop,'' DKFZ Heidelberg, 25-28 November 1999, Handbook͒ to compare the doses calculated by the TMS system with the measurements taken on our linac for all the clinical cases we performed. 4 …”

Section: Methodsmentioning

confidence: 99%

Quality assurance in IMRT: Importance of the transmission through the jaws for an accurate calculation of absolute doses and relative distributions

Azcona¹,

Siochi²,

Azinovic³

2002

Medical Physics

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The goal of IMRT is to achieve an isodose distribution conformed to the tumor while avoiding the organs at risk. For these tasks several gantry angles are selected, each one containing a series of different leaf configurations for the multileaf collimator ͑MLC͒ ͑segments͒. Verifying the relative distributions as well as the absolute doses is an important step for quality assurance issues. We have observed that an accurate modeling of the transmission of the primary x-ray fluence through the jaws and MLC as well as the head scatter is crucial for a precise calculation of relative doses and monitor units. Also, an inaccurate calculation of the output factor for small size segments can lead to important differences in the absolute dose for points under these segments. Incorrect models could lead to systematic errors of around 5% to 10% in the calculated monitor units and a shift in the isodose curves.

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“…However, IMRT is the output of each point in the wild dose rate adjusted to realize high doses in the three dimensional space of the agreement ,but target body outside of the dose fell rapidly, which realizes without any increase in normal tissue complications probability under the premise of improve tumor local illuminate dose and local control. The reverse calculation of the optimization algorithm in IMRT is still not mature in some ways, including some uncertain factors in radiotherapy, we should assure the dose learning verification treatment as a key step before treatment of high metabolism (Bortfeld et al, 1994;Tsai et al, 1998). At home and abroad, the verification methods of common dose contains absolute and relative doses verification (Li et al, 2002;Agazaryan et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Dosimetric Verification for Primary Focal Hypermetabolism of Nasopharyngeal Carcinoma Patients Treated with Dynamic Intensity-modulated Radiation Therapy

Xin

Wang²,

Li³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Objective: To make sure the feasibility with 18F FDG PET/CT to guided dynamic intensity-modulated radiation therapy (IMRT) for nasopharyngeal carcinoma patients, by dosimetric verification before treatment. Methods: Chose 11 patients in Ⅲ~ⅣA nasopharyngeal carcinoma treated with functional image-guided IMRT and absolute and relative dosimetric verification by Varian 23EX LA, ionization chamber, 2DICA of I'mRT Matrixx and IBA detachable phantom. Drawing outline and making treatment plan were by different imaging techniques (CT and 18F FDG PET/CT). The dose distributions of the various regional were realized by SMART. Results: The absolute mean errors of interest area were 2.39%±0.66 using 0.6cc ice chamber. Results using DTA method, the average relative dose measurements within our protocol (3%, 3 mm) were 87.64% at 300 MU/min in all filed. Conclusions: Dosimetric verification before IMRT is obligatory and necessary. Ionization chamber and 2DICA of I'mRT Matrixx was the effective dosimetric verification tool for primary focal hyper metabolism in functional image-guided dynamic IMRT for nasopharyngeal carcinoma. Our preliminary evidence indicates that functional image-guided dynamic IMRT is feasible.

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Realization and verification of three-dimensional conformal radiotherapy with modulated fields

Cited by 203 publications

References 23 publications

A simple model for examining issues in radiotherapy optimization

A simple model for examining issues in radiotherapy optimization

Quality assurance in IMRT: Importance of the transmission through the jaws for an accurate calculation of absolute doses and relative distributions

Dosimetric Verification for Primary Focal Hypermetabolism of Nasopharyngeal Carcinoma Patients Treated with Dynamic Intensity-modulated Radiation Therapy

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