Realizing Both Antibacterial Activity and Cytocompatibility in Silicocarnotite Bioceramic via Germanium Incorporation

Ji, Yingqi; Yang, Shun; Sun, Jian; Ning, Congqin

doi:10.3390/jfb14030154

Cited by 5 publications

(2 citation statements)

References 56 publications

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“…On the other hand, the crucial information is that Ge compounds are relatively less toxic when compared to other metalloids and metals [6]. Based on this, Ge is used for medical purposes as different agents to repair bones with infected bone defects [7]. Ge is not cytotoxic at a low doping level and is not carcinogenic [8], and even appears to inhibit inflammatory processes in the effective clinical treatment for mastitis and other inflammatory diseases [9,10].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Behaviour of an Au-Ge Alloy in an Artificial Saliva and Sweat Solution

Vastag,

Majerič,

Lazić

et al. 2024

Metals

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In modern times, more and more different materials (including alloys) are in direct contact with human electrolytes (sweat, saliva, lymph, blood, etc.). One of the most important properties for the use of these materials is therefore their chemical inertness or resistance to corrosion when they are in contact with human electrolytes. Consequently, during the development of such new materials, it is necessary to study and understand their basic electrochemical behaviour in a given environment. The purpose of this research was to monitor the electrochemical behaviour of the new Au-Ge alloy in artificial sweat and artificial saliva solutions, depending on the electrolyte composition and exposure time. This new alloy represents a potential material for use in dentistry or for jewellery. The obtained results of the study show that the immersion time and the pH value have a significantly greater influence on the corrosion resistance of the new Au-Ge alloy than the composition of the electrolyte solution. The results of the SEM/EDX analysis additionally confirm the main results of the electrochemical measurements.

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Section: Introductionmentioning

confidence: 99%

Electrochemical Behaviour of an Au-Ge Alloy in an Artificial Saliva and Sweat Solution

Vastag,

Majerič,

Lazić

et al. 2024

Metals

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“…Phosphate-based glass with Ge additive (GeO 2 ) was developed to enhance nuclear radiation-shielding behaviors and mechanical properties 17 . Owing to the antimicrobial activity of Ge, GeO 2 was used to enhance the antibacterial properties of silicocarnotite bioceramic, where results showed effective antibacterial activity against Escherichia coli and Staphylococcus aureus 18 .…”

Section: Introductionmentioning

confidence: 99%

Molecular and biological activities of metal oxide-modified bioactive glass

Tiama¹,

Elhaes

Ibrahim

et al. 2023

Sci Rep

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Bioactive glass (BG) was prepared by sol–gel method following the composition 60-($$x$$ x ) SiO2.34CaO.6P2O5, where x = 10 (FeO, CuO, ZnO or GeO). Samples were then studied with FTIR. Biological activities of the studied samples were processed with antibacterial test. Model molecules for different glass compositions were built and calculated with density functional theory at B3LYP/6-31 g(d) level. Some important parameters such as total dipole moment (TDM), HOMO/LUMO band gap energy (ΔE), and molecular electrostatic potential beside infrared spectra were calculated. Modeling data indicated that P4O10 vibrational characteristics are enhanced by the addition of SiO2.CaO due to electron rush resonating along whole crystal. FTIR results confirmed that the addition of ZnO to P4O10.SiO2.CaO significantly impacted the vibrational characteristics, unlike the other alternatives CuO, FeO and GeO that caused a smaller change in spectral indexing. The obtained values of TDM and ΔE indicated that P4O10.SiO2.CaO doped with ZnO is the most reactive composition. All the prepared BG composites showed antibacterial activity against three different pathogenic bacterial strains, with ZnO-doped BG demonstrating the highest antibacterial activity, confirming the molecular modeling calculations.

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Recent Developments in Antimicrobial and Antiviral Agents Based on Natural/Synthetic Polymers and Dendrimers: Design and Therapeutic Applications

Abd‐El‐Aziz,

Fouda,

Sharaby

et al. 2024

Macro Chemistry & Physics

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This review article explores the recent innovations in the field of antimicrobial and antiviral macromolecules. With the rising challenge of antibiotic resistance, as well as the overuse of antibiotics, there is a growing demand for efficient solutions to combat microbial and viral infections. The development of new effective antimicrobial and antiviral agents is highlighted. This review was designed to give a comprehensive view of the literature focusing on a few examples of combating microbial and viral infections in each section. A brief description of naturally occurring organic‐based materials that exhibited antimicrobial and/or antiviral activities is presented, focusing on polysaccharides, peptides and proteins. Synthetic organic‐based materials are divided into subsections including polymers, dendrimers, and nanomaterials. The synthesis and applications of inorganic materials such as polyphosphazenes and polysiloxanes, as well as tin‐, germanium‐ and gallium‐based materials are emphasized in this review. Organometallic macromolecules are also described, and their antimicrobial and antiviral activities are examined. Overall, this article provides a comprehensive overview of recent advancements in the design of antimicrobial and antiviral macromolecules, offering valuable insights into their potential applications in biomedical research and combating drug‐resistant microorganisms and viruses.This article is protected by copyright. All rights reserved

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Realizing Both Antibacterial Activity and Cytocompatibility in Silicocarnotite Bioceramic via Germanium Incorporation

Cited by 5 publications

References 56 publications

Electrochemical Behaviour of an Au-Ge Alloy in an Artificial Saliva and Sweat Solution

Electrochemical Behaviour of an Au-Ge Alloy in an Artificial Saliva and Sweat Solution

Molecular and biological activities of metal oxide-modified bioactive glass

Recent Developments in Antimicrobial and Antiviral Agents Based on Natural/Synthetic Polymers and Dendrimers: Design and Therapeutic Applications

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