Rec assay and mutagenicity studies on metal compounds

Kanematsu, Nobutake; Hara, Masako; Kada, Tsuneo

doi:10.1016/0165-1218(80)90127-5

Cited by 298 publications

(69 citation statements)

References 18 publications

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“…Aspects such as genotoxicity [106][107][108][109] or metalloestrogenecity [110,111] will not be discussed here, but no firm conclusions can be drawn from the scant published studies. Initial data on the effect of antimony on the microbial growth and the activities of soil enzymes have recently become available.…”

Section: What Is More Toxic?mentioning

confidence: 99%

Antimony in the environment: knowns and unknowns

2009

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Environmental context. Antimony first attracted public attention in the mid-1990s amid claims that it was involved in Sudden Infant Death Syndrome. A substantial number of papers have now been published on the element and its behaviour in the natural environment. However, many key aspects of the environmental chemistry of antimony remain poorly understood. These include critical areas such as its ecotoxicology, its global cycling through different environmental compartments, and what chemical form it takes in different environments. More focussed research would help the situation. The present review highlights several areas of environmental antimony chemistry that urgently need to be addressed.Abstract. The objective of the present article is to present a critical overview of issues related to the current state of knowledge on the behaviour of antimony in the environment. It makes no attempt to systematically review all published data. However, it does provide a list of the main published reviews on antimony and identifies subjects where systematic reviews are needed. Areas where our knowledge is strong -and the corresponding gaps -in subjects ranging from total concentrations and speciation in the various environmental compartments, to ecotoxicity, to cycling between compartments, are discussed, along with the underlying research. Determining total antimony no longer poses a problem for most environmental samples but speciation measurements remain challenging throughout the process, from sampling to analysis. This means that the analytical tools still need to be improved but experience shows that, to be useful in practice, this should be directly driven by the requirements of laboratory and field measurements. Many different issues can be identified where further research is required, both in the laboratory and in the field, the most urgently needed studies probably being: (i) long-term spatial and temporal studies in the different environmental compartments in order to collect the data needed to establish a global biogeochemical cycle; (ii) laboratory studies of antimony interactions with potential natural binders; (iii) reliable ecotoxicological studies. Montserrat Filella is a chemist and teaches Environmental Chemistry at the University of Geneva, Switzerland. Her main research interests focus on the understanding of the physicochemical processes regulating the behaviour of chemical components in environmental and biological compartments, mainly by combining computer modelling with field and laboratory measurements. The three main axes of her research concern the study of: colloids in natural waters, natural organic matter (quantification and interaction with trace elements) and Group 15 elements. She is also interested in other topics

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Section: What Is More Toxic?mentioning

confidence: 99%

Antimony in the environment: knowns and unknowns

2009

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“…It can be seen (Table IX) (Sirover & Loeb, 1976;Tkeshelashvili et al, 1980), point mutations in bacteria (Venitt & Levy, 1974;Nishioka, 1975;Green et al, 1976;Petrilli & De Flora, 1978b;Lofroth, 1978;Nakamuro et al, 1978;Nestmann et al, 1979;Kada et al, 1980;Kanematsu et al, 1980;De Flora, 1981), yeast (Bonatti et al, 1976) and mammalian cells (Newbold et al, 1-979); and gene conversion (Bonatti et al, 1976) and mitotic reconmbination (Nestmann et al, 1979) in yeasts; chromosomal aberrations (Tsuda & Kato, 1977;Nakamuro et al, 1978;Newbold et al, 1979;Umeda & Nishimura, 1979;Douglas et al, 1980); SCE Majone & Rensi, 1979;MacRae et al, 1979;Douglas et al, 1980); DNA damage Tamino & Peretta, 1980;Douglas et al, 1980;Tamino et al, 1981); DNA repair synthesis ; morphological transformation (Fradkin et al, 1975;Tsuda & Kato, 1977; and enhancement of viral transformation in cultured mammalian cells; increased frequency of micronuclei and chromosomal aberrations in cells of rodents treated in vivo (Wild, 1978) as well as in lymphocytes of professionally exposed workers (Bigaliev et al, 1977). Cr(VI) compounds gave positive results in the mouse "spot" test (Knudsen, 1980) and transformed Syrian hamster cells when injected into pregnant hamsters , thus indicating that they are also transplacental mutagens.…”

Section: Chromium Accumulation and Stability In Bhk Cellsmentioning

confidence: 99%

“…On the contrary, Cr(III) salts are usually inactive in mutagenicity tests (Venitt & Levy, 1974;Nishioka, 1975;Petrilli & De Flora, 1978b;Kada et al, 1980;Kanematsu et al, 1980;De Flora, 1981) except in systems involving a direct interaction with DNA purified in vitro, such as damage shown by the alteration of its physico-chemical properties (Tamino & Peretta, 1980;Tamino et al, 1981) and increased error frequency during replication (Sirover & Loeb, 1976;Tkeshelashvili 1980). The only frequent cytogenetic effect in mammalian cells treated in vitro with Cr(III) compounds is the increase of chromosome aberrations (Nakamuro et al, 1978;Levis & Mlajone, 1979; see also the present data), but it is obtained with doses much higher than the active Cr(VI) concentrations, and could be related to an indirect effect produced by such extreme conditions, e.g.…”

Section: Chromium Accumulation and Stability In Bhk Cellsmentioning

confidence: 99%

Cytotoxic and clastogenic effects of soluble and insoluble compounds containing hexavalent and trivalent chromium

Levis¹,

Majone²

1981

Br J Cancer

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“…1980;Robison et al 1982;Scicchitano and Pegg 1987). However, silver has not been found to be mutagenic in bacteria (Demerec et al 1951;Kanematsu et al 1980;McCoy and Rosenkranz 1978;Nishioka 1975;Rossman and Molina 1986).…”

Section: Genotoxic Effectsmentioning

confidence: 99%