1993
DOI: 10.1101/sqb.1993.058.01.063
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RecA-like Recombination Proteins in Eukaryotes: Functions and Structures of RAD51 Genes

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Cited by 109 publications
(86 citation statements)
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“…The tissue distribution of canine Brca2 and Rad51 mRNA was investigated by RT-PCR, using RNA from testis, ovary, mammary gland, spleen, skeletal muscle, and brain. As previously reported in human and mouse [3,14,16,19], Brca2 and Rad51 mRNA were expressed in mammary gland, testis, ovary, and brain (Fig. 5).…”
Section: Resultssupporting
confidence: 49%
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“…The tissue distribution of canine Brca2 and Rad51 mRNA was investigated by RT-PCR, using RNA from testis, ovary, mammary gland, spleen, skeletal muscle, and brain. As previously reported in human and mouse [3,14,16,19], Brca2 and Rad51 mRNA were expressed in mammary gland, testis, ovary, and brain (Fig. 5).…”
Section: Resultssupporting
confidence: 49%
“…In contrast to Brca2, the canine Rad51 protein has extremely high homology (99%) with the human and mouse proteins. Rad51 is a homologue of Escherichia coli recombination protein RecA [13], and the conservation of the sequence indicates its importance throughout evolution [14].…”
Section: Discussionmentioning
confidence: 99%
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“…These ssDNA tails can be detected in vivo as intermediates during mating-type switching (White and Haber, 1990) and during meiotic recombination (Sun et al, 1989(Sun et al, , 1991Cao et al, 1990). Intermediates with ssDNA tails accumulate if the strand invasion step is blocked by a mutation in the RAD51, gene during mating-type switching and also in DMC1 during meiotic recombination (Bishop et al, 1992;Shinohara et al, 1992;Sugawara and Haber, 1992;Ogawa et al, 1993;Sugawara et al, 1995). Several of these genes, RAD51,, and DMC1, encode homologues of the Escherichia coli RecA protein.…”
Section: Introductionmentioning
confidence: 99%
“…In addition, HsRad52 and S. pombe Rad52 (Rad22) appear to bind to DSBs (12,13). Rad51 is an eukaryotic structural and functional counterpart of Escherichia coli RecA (14). Purified ScRad51 and HsRad51 have the homologous pairing/ strand exchange activity that is the core catalytic activity of HR (15).…”
mentioning
confidence: 99%