Recent Advance in Biological Responsive Nanomaterials for Biosensing and Molecular Imaging Application

Abstract

In recent decades, as a subclass of biomaterials, biologically sensitive nanoparticles have attracted increased scientific interest. Many of the demands for physiologically responsive nanomaterials in applications involving the human body cannot be met by conventional technologies. Due to the field’s importance, considerable effort has been expended, and biologically responsive nanomaterials have achieved remarkable success thus far. This review summarizes the recent advancements in biologically responsive nanomaterials and their applications in biosensing and molecular imaging. The nanomaterials change their structure or increase the chemical reaction ratio in response to specific bio-relevant stimuli (such as pH, redox potentials, enzyme kinds, and concentrations) in order to improve the signal for biologically responsive diagnosis. We use various case studies to illustrate the existing issues and provide a clear sense of direction in this area. Furthermore, the limitations and prospects of these nanomaterials for diagnosis are also discussed.

Synthesis of Flurbiprofen Based Amide Derivatives as Potential Leads for Diabetic Management: In Vitro α‐glucosidase Inhibition, Molecular Docking and DFT Simulation Approach

“…The values $${\nabla ^2 p_{\left( r \right)} }$$ and $${G\left( {r{\rm{BCP}}} \right)}$$ +$${\gamma \left( {r{\rm{BCP}}} \right)}$$ being >0 denote a strong hydrogen bond which represented blue dot as; F⋅⋅⋅C=C Phenyl for ( 2 a – 2 n) , C=O⋅⋅⋅NH for 2 f , C=O⋅⋅⋅O=C for ( 2 h , 2 m and 2 n) , C=O⋅⋅⋅C=C phenyl for ( 2 g , 2 i and 2 k ), C=O⋅⋅⋅N=C for ( 2 j ) and C=O⋅⋅⋅S−C for (2 l) . The proportion of $${G\left( {r{\rm{BCP}}} \right)}$$ /$${\gamma \left( {r{\rm{BCP}}} \right)}$$ is equivalent to 1.011–1.017 ff which is indicative of non‐covalent hydrogen bond dynamic [48,50] . The RCP was present in both phenyl rings of flurbiprofen derivatives 2 a – 2 n .…”

Evaluation of machine learning models for predicting TiO2 photocatalytic degradation of air contaminants

“…Moreover, TiO 2 finds application in a wide range of areas, including air purification, water treatment, water splitting, renewable energy production, and the conversion of carbon dioxide into hydrocarbons [10][11][12][13][14] . In recent decades, extensive efforts have been dedicated to the development of photocatalysts and the assessment of their effectiveness in municipal water treatment processes [15][16][17][18][19] . Nevertheless, quantifying the efficiency of photocatalysts across a spectrum of contaminants presents a difficult challenge.…”

Employing Spectroscopic, Electrochemical, and In Silico Research to Investigate the Interaction of Ofloxacin, Antibacterial Drug With the Haemoglobin

“…A static quenching technique was used to eliminate BSA's inherent fluorescence. The hydrophobic and electrostatic interactions are primarily responsible for affinity of complexes towards the BSA [5,6] . The interaction of ofloxacin with DNA of fish has been investigated by electrochemical, in silico, and spectroscopic methods (UV and fluorescence spectroscopy).…”