Recent advancements in surface plasmon resonance immunosensors for detection of small molecules of biomedical, food and environmental interest

Shankaran, Dhesingh Ravi; Gobi, K. Vengatajalabathy; Miura, Norio

doi:10.1016/j.snb.2006.09.014

Cited by 552 publications

(330 citation statements)

References 180 publications

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“…Surface plasmon resonance (SPR) biosensors are powerful optical tools in biotechnology and medicine because they can be used for sensitive detection and real-time monitoring of (bio)chemical interactions [1]. Furthermore, coupling SPR to fiber optic (FO) technology triggered notable advancements in the field, by offering attractive advantages over the classical prism-based SPR platforms, such as simplicity, portability, cost-effectiveness and miniaturization [2].…”

Section: Introductionmentioning

confidence: 99%

Thermal annealing of gold coated fiber optic surfaces for improved plasmonic biosensing

Antohe

Schouteden

Goos

et al. 2016

Sensors and Actuators B: Chemical

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The morphological properties of thin gold (Au) films sputtered onto fiber optic (FO) substrates play an essential role in the overall performance of the sensing devices relying on surface plasmon resonance (SPR) effects. In this work, the influence of thermal treatments on the structural changes of the Au layer coated on the FO-SPR sensors, and consequently on their plasmonic biosensing performance, was systematically investigated. First, the sensors were exposed to different annealing temperatures for different durations and their sensitivity was evaluated by refractometric measurements in sucrose dilutions. The attained results suggested the optimal annealing conditions that were further validated using a split-plot experimental design statistical model. Room-temperature scanning tunneling microscopy (STM) imaging of the FO substrates revealed changes in the granular surface texture of the thermally treated Au films that could be linked to the observed increase in sensitivity of the treated sensors. The FO sensors, annealed under optimal conditions, were finally tested as label-free aptamer -based biosensors for the detection of Ara h 1 peanut allergen. Remarkably, the results demonstrated a superior biosensing performance of the thermally treated FO sensors, as the limit of detection (LOD) was improved with up to two orders of magnitude compared to a similar non-annealed FO-SPR sensor. This significant increase in sensitivity represents a major step forward in the facile and cost-effective preparation of FO-SPR sensors capable of label-free detection of various biomolecular targets.

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Section: Introductionmentioning

confidence: 99%

Thermal annealing of gold coated fiber optic surfaces for improved plasmonic biosensing

Antohe

Schouteden

Goos

et al. 2016

Sensors and Actuators B: Chemical

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“…Compared to the intensity-interrogated SPR sensor, the MOSPR sensor only requires an electromagnet placed in transversal configuration, and a MP transducer instead of the gold layer transducer of the SPR biosensor. These features turn the MOSPR biosensor into a simple solution to improve the LOD of SPR biosensors, which could be of paramount utility for high sensitivity applications, as for example in clinical diagnostics, 20,21 food safety, 22 and environmental protection. 23 In order to surpass the sensing features of the SPR sensor, the MP transducer must have a large MO activity and a well-defined SPR; i.e., a sharp and angular narrow resonance.…”

Section: Introductionmentioning

confidence: 99%

Au/Fe/Au multilayer transducers for magneto-optic surface plasmon resonance sensing

Regatos¹,

Fariña²,

Calle³

et al. 2010

Journal of Applied Physics

100

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In this paper, we analyze the magnetoplasmonic ͑MP͒ features and sensing capabilities of Au/Fe/Au trilayer structures, as transducers of the magneto-optic surface plasmon resonance ͑MOSPR͒ biosensor. This biosensor, which can surpass the sensitivity of the standard SPR sensor, is based on a MP modulation technique generated by the simultaneous stimulation of the surface plasmon polaritons ͑SPP͒ and the transversal magneto-optical Kerr effect ͑TMOKE͒. We study the magneto-optical activity of the trilayers as a function of the thickness and position of the Fe layer. We first demonstrate that this kind of structure allows modulating the SPP through an external magnetic field and moreover, induce a strong enhancement of the TMOKE effect. The modulation of the SPP is linearly proportional to the thickness of Fe layer and inversely proportional to the distance between the Fe layer and the external dielectric medium. Finally, we experimentally confirm a twofold increase in the MOSPR sensitivity with respect to the intensity-interrogated SPR biosensor in bulk refractive-index changes, keeping a similar chemical resistance and stability, unprecedented in other MP transducers, and biofunctionalization protocols.

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“…For example, McPhillips et al [75] employed aligned Au nanotube arrays to strengthen performance of refractive index sensors in biomolecular binding reactions. Generally, sandwich [76] and competitive or inhibition assay [77] are two major detection approaches in SPR biosensor. In 2012, Fernandez et al [78] demonstrated that AuNMs combined with sandwich assays could improve detection sensitivity and selectivity of protein detection.…”

Section: Biomoleculesmentioning

confidence: 99%

Advanced AuNMs as nanomedicine’s central goals capable of active targeting in both imaging and therapy in biomolecules

Lh¹

2017

Glob Drugs Therap

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Recent advancements in surface plasmon resonance immunosensors for detection of small molecules of biomedical, food and environmental interest

Cited by 552 publications

References 180 publications

Thermal annealing of gold coated fiber optic surfaces for improved plasmonic biosensing

Thermal annealing of gold coated fiber optic surfaces for improved plasmonic biosensing

Au/Fe/Au multilayer transducers for magneto-optic surface plasmon resonance sensing

Advanced AuNMs as nanomedicine’s central goals capable of active targeting in both imaging and therapy in biomolecules

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