Recent advances and challenges in peptide drug development

Kumar, Niranjan; Rao, K. Poornachandra; Somashekaraiah, Rakesh; Jagannath, Shobha; Sreenivasa, M.Y.

doi:10.1016/b978-0-323-85682-9.00001-5

Cited by 2 publications

(2 citation statements)

References 49 publications

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“…Z‐ DOCK [ 109 ] is one such program that produces accurate PPI predictions if accurate scoring scaffolds are given. [ 110,111 ] To produce more precise predictions on the binding affinities between the interacting proteins, flexible‐body docking methods require structural information such as the hydrogen bonds, buried area of the surface, allosteric effects, angles of geometry, and hotspots for mutation for calculations of binding free energies. [ 112 ] The well‐known PPI prediction service ATTRACT [ 113 ] has robust toolkits that cover a wide range of scoring parameters, although it is a bit complex to operate.…”

Section: Peptide Designing and Molecular Docking: The Ultimate Saviormentioning

confidence: 99%

“…[ 117,118 ] The most widely used techniques that offer several strategies for determining peptide‐binding sites are Rosetta FlexPepDock, [ 119 ] and PepCrawler. [ 111,120 ] Rosetta FlexPepDock [ 119 ] reduces optimization stages to produce outstanding conformational samples for binding motifs well characterized with the residues of hotspots. It is a Monte Carlo‐based method.…”

Section: Peptide Designing and Molecular Docking: The Ultimate Saviormentioning

confidence: 99%

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Review on therapeutic potential of peptides: Advancements in synthesis methods, linear and cyclic peptides, and strategies for overcoming challenges

Lalani,

Tivari,

Jain

et al. 2024

Peptide Science

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In the realm of therapeutic peptides, tremendous progress has been achieved in the last two decades. The building block of peptides that is, ‘Amino Acid’ has been modified by various chemical modifications such as side‐chain alteration in linear peptides, cyclization, back‐bone modification, pro‐drug moiety, conjugation with heterocycles, and natural products to make peptides a foremost candidate as a therapeutic drug. Since the advent of insulin in 1922, peptides have immensely affected the development of the pharmaceutical industry giving rise to the peptide‐based drug industry. In recent years, peptides having antimicrobial, antiviral, anti‐tumor, anti‐inflammatory, anti‐aging, and antioxidant properties have developed. Also, it has now entered as a potent candidate in the field of oncology and also become a valuable tool as a radiolabeled peptide for the detection of various diseases. Generally, peptides were extracted from natural sources in the olden days, but presently work is directed towards finding alternate and sustainable ways for developing synthetic peptides. The present review covers the discussion about the historic evaluation of peptides, available effective synthetic processes, current advancements, use of bioinformatic tools, computational strategies, and the methodology to overcome the barrier for making peptides the potent candidate for the future world.

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Section: Peptide Designing and Molecular Docking: The Ultimate Saviormentioning

confidence: 99%

Section: Peptide Designing and Molecular Docking: The Ultimate Saviormentioning

confidence: 99%

Review on therapeutic potential of peptides: Advancements in synthesis methods, linear and cyclic peptides, and strategies for overcoming challenges

Lalani,

Tivari,

Jain

et al. 2024

Peptide Science

View full text Add to dashboard Cite

show abstract

Peptide Drugs: Current Status and it's Applications in the Treatment of Various Diseases

Chandarana,

Juwarwala,

Shetty

et al. 2024

CDRR

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Peptides represent a class of natural molecules with diverse physiological functions, including hormone regulation, neurotransmission, and immune modulation. In recent years, peptide-based therapeutics have gained significant attention in pharmaceutical research and development due to their high specificity, efficacy, and relatively low toxicity. This review provides an overview of the current landscape of peptide drug development, highlighting the challenges faced in their formulation and delivery and the innovative strategies employed to overcome these hurdles. The review explores the wide range of applications of peptide drugs in treating various diseases, including HIV, multiple sclerosis, osteoporosis, chronic pain, diabetes, and cancer. Examples of FDA-approved peptide drugs and ongoing clinical trials are presented, showcasing the continuous advancements in peptide-based therapeutics across different therapeutic areas. This review underscores the promising potential of peptide drugs as targeted and effective treatments for a multitude of medical conditions, offering improved therapeutic outcomes and enhanced patient care.

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Recent advances and challenges in peptide drug development

Cited by 2 publications

References 49 publications

Review on therapeutic potential of peptides: Advancements in synthesis methods, linear and cyclic peptides, and strategies for overcoming challenges

Review on therapeutic potential of peptides: Advancements in synthesis methods, linear and cyclic peptides, and strategies for overcoming challenges

Peptide Drugs: Current Status and it's Applications in the Treatment of Various Diseases

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