Recent advances for commedonal acne treatment by employing lipid nanocarriers topically

Patnaik, Swastik; Purohit, Debashis; Biswasroy, Prativa; Diab, Walaa Mohammad; Dubey, Anubhav

doi:10.53730/ijhs.v6ns8.9671

Cited by 14 publications

(7 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…AV is a multifactorial disorder, with genetic factors being the main factor for its pathomechanism [13] . It develops as a result of an interaction of increased sebum production, follicular epidermal hyper proliferation with subsequent plugging of the orifices, P. acnes activity, and inflammatory response [14] .…”

Section: Resultsmentioning

confidence: 99%

Assessment of Serum Interleukin-23 in Acne Vulgaris Patients and Its Correlation with Disease Severity

2023

The Egyptian Journal of Hospital Medicine

View full text Add to dashboard Cite

Background: Acne vulgaris (AV) is a chronic inflammatory disease of the pilosebaceous unit, which affects adolescents and young adults. Interleukin (IL)-23 and IL-17 have been found to significantly influence the chronic inflammatory response. Furthermore, the discovery of their pathways had contributed to a better understanding of the pathomechanism of inflammatory disorders. Objective: This study aimed at measuring serum IL-23 concentrations among AV cases with different severities and to compare them with normal controls. Patients and Methods: This case-control study included 80 subjects who were allocated into 2 groups: Group (A) included 40 cases with acne vulgaris, and group (B) included 40 healthy controls. In the patient group, the Global Acne Grading System Severity (GAGS) was utilized in evaluating the AV severity. Results:The mean serum IL-23 level was statistically significantly greater in the AV group (48.57 ± 17.63 pg/mL) compared to the control group (11.81 ± 4.28 pg/mL). No significant differences were found regarding serum IL-23 concentrations between child versus adult, males versus females, as well as different nutritional status among AV group. There was significant increase in serum IL-23 concentrations with increased severity of AV group (p < 0.001). Conclusion:Serum IL-23 is not only a marker of the pathogenetic process of AV but also it can serve as a prognostic predictor for AV severity.

show abstract

Section: Resultsmentioning

confidence: 99%

Assessment of Serum Interleukin-23 in Acne Vulgaris Patients and Its Correlation with Disease Severity

2023

The Egyptian Journal of Hospital Medicine

View full text Add to dashboard Cite

show abstract

“…While some studies have investigated the potential of tretinoin ethosomes as a treatment for various skin conditions such as acne and photoaging, more research is needed to confirm the safety and efficacy of Tretinoin ethosomes and to establish its ability to get FDA approval. 62 Moreover, benzoyl peroxide is an antimicrobial agent that is commonly used to treat acne. Benzoyl peroxide is usually used in topical form and it is available over the counter under different brand names like Clearasil®, Oxy® and many others.…”

Section: Ethosomes For Acnesmentioning

confidence: 99%

“…Currently, tretinoin ethosomes is not a drug that is available in the market. While some studies have investigated the potential of tretinoin ethosomes as a treatment for various skin conditions such as acne and photoaging, more research is needed to confirm the safety and efficacy of Tretinoin ethosomes and to establish its ability to get FDA approval 62 …”

Section: Ethosomes Applications In Cosmetic Deliverymentioning

confidence: 99%

Unlocking the potential of cosmetic dermal delivery with ethosomes: A comprehensive review

Abu‐Huwaij

Zidan

2023

J of Cosmetic Dermatology

View full text Add to dashboard Cite

BackgroundIn a world where hair loss, acne, and skin whitening are common concerns, ethosomes emerge as a captivating breakthrough in cosmetic drug delivery.MethodThis review provides a comprehensive overview of the ethosomal system and assesses its potential as an effective nanocarrier for delivering active ingredients to the skin. The focus is on exploring their applications in various pathologies, particularly skin disorders such as acne, hair loss, and skin pigmentation.ResultsEthosomes are a novel type of vesicular nanocarrier composed of high concentrations of ethanol (20‐45%) and phospholipids. Their unique structure and composition make them an ideal choice for transporting active ingredients through the skin, offering targeted and effective treatment. The inclusion of ethanol in ethosomes' composition gives them distinctive properties, including flexibility, deformability, and stability, facilitating deep penetration into the skin and enhancing medication deposition. Moreover, ethosomes improved theoverall drug‐loading capacity, and specificity of target treatmentConclusionEthosomes represent a unique and suitable approach for delivering active cosmetic ingredients in the treatment of hair loss, acne, and skin whitening, presenting a versatile alternative to traditional dermal delivery systems. Despite the challenges associated with their complex preparation and sensitivity to temperature and humidity, the remarkable potential benefits of ethosomes cannot be ignored. Further research is crucial to unlock their full potential, understand their limitations, and refine their formulations and administration methods. Ethosomes hold the promise of transforming the way we address these cosmetic concerns, offering an exciting glimpse into the future of advanced skincare solutions.

show abstract

“…It appears on skin that has an abundance of hair growth, such as the upper chest, back, and face. 4,5 The typical early lesions of acne are comedones, either closed or open comedones. The first lesions, which may include inflamed papules, pustules, and inflamed cystic nodules with induration, can lead to severe acne.…”

Section: Introductionmentioning

confidence: 99%

“…It appears on skin that has an abundance of hair growth, such as the upper chest, back, and face. 4 , 5 …”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Effect of Oral Isotretinoin on the Level of Serum YKL40 in Acne Vulgaris Patients: A Cross-Sectional Case-Control

Ali,

El Taieb,

Hegazy

et al. 2023

CCID

View full text Add to dashboard Cite

In the entire world, acne vulgaris (AV) is the most prevalent skin condition. Approximately 9.4% of people worldwide have acne vulgaris. This study compared the blood levels of chitinase 3-like protein 1 (YKL-40) in acne vulgaris patients before and after oral isotretinoin therapy. Patients and Methods:The design of the study was cross-sectional case-control. Forty patients with moderate to severe acne vulgaris and twenty healthy participants participated in this study. Using the Global Acne Grading System (GAGS) score, patients with acne vulgaris were evaluated both before and after concluding their treatment. Using the enzyme-linked immunosorbent assay (ELISA), the serum levels of YKL-40 were measured before and after oral isotretinoin therapy in healthy controls and acne patients. Results: Patients with acne vulgaris had considerably greater serum levels of YKL-40 than healthy control subjects (p 0.001) did. After three months of oral isotretinoin medication, the GAGS score and blood levels of YKL-40 in acne vulgaris patients both significantly decreased. Conclusion:The conclusion of this study was that reducing the blood levels of YKL-40 and the GAGS score in patients with acne vulgaris who took oral isotretinoin for three months was a crucial strategy.

show abstract

Recent advances for commedonal acne treatment by employing lipid nanocarriers topically

Cited by 14 publications

References 34 publications

Assessment of Serum Interleukin-23 in Acne Vulgaris Patients and Its Correlation with Disease Severity

Assessment of Serum Interleukin-23 in Acne Vulgaris Patients and Its Correlation with Disease Severity

Unlocking the potential of cosmetic dermal delivery with ethosomes: A comprehensive review

Evaluation of the Effect of Oral Isotretinoin on the Level of Serum YKL40 in Acne Vulgaris Patients: A Cross-Sectional Case-Control

Contact Info

Product

Resources

About