Recent Advances in Anticancer Activities and Drug Delivery Systems of Tannins

Abstract

Tannins, polyphenols in medicinal plants, have been divided into two groups of hydrolysable and condensed tannins, including gallotannins, ellagitannins, and (-)-epigallocatechin-3-gallate (EGCG). Potent anticancer activities have been observed in tannins (especially EGCG) with multiple mechanisms, such as apoptosis, cell cycle arrest, and inhibition of invasion and metastases. Furthermore, the combinational effects of tannins and anticancer drugs have been demonstrated in this review, including chemoprotective, chemosensitive, and antagonizing effects accompanying with anticancer effect. However, the applications of tannins have been hindered due to their poor liposolubility, low bioavailability, off-taste, and shorter half-life time in human body, such as EGCG, gallic acid, and ellagic acid. To tackle these obstacles, novel drug delivery systems have been employed to deliver tannins with the aim of improving their applications, such as gelatin nanoparticles, micelles, nanogold, liposomes, and so on. In this review, the chemical characteristics, anticancer properties, and drug delivery systems of tannins were discussed with an attempt to provide a systemic reference to promote the development of tannins as anticancer agents.

Influence of the hybrid materials based on carbon nanotubes and tannic acid on the rheological, thermal and mechanical performances of nitrile butadiene rubber composites

“…As a natural polyphenol, tannic acid (TA) is widely distributed in nature. Benefits from the low‐cost, eco‐friendly, and presence of abundant pyrogallol and catechol groups makes it highly possessive of various applications, such as absorption, coating, food additives, and biomedical materials . In some recent studies, Tang et al reported that TA was introduced as a modifier in boehmite‐filled styrene‐butadiene rubber composites, which have enhanced the mechanical properties and gas barrier property of the rubber.…”

Formulation Strategies to Improve Oral Bioavailability of Ellagic Acid

“…EA is a chromene-dione derivative (2,3,7,8-tetrahydroxy-chromeno [5,4,3-cde]chromene-5,10dione), encompassing both a hydrophilic moiety with 4 hydroxyl groups and 2 lactone groups, and a planar lipophilic moiety with 2 biphenyl rings. This particular structure has both hydrogenbonding acceptor (lactone) and donor (−OH) sites ( Figure 1).…”

“…Present also in a large variety of tropical fruits, nuts, berries (strawberries, raspberries, blackberries, cranberries, goji berries) and in a type of edible mushroom (Fistulina epatica), EA has recently attracted deep interest, since many research studies evidenced the role of oxidative stress in different pathologic conditions like cancer, diabetes, cardiovascular and autoimmune diseases, obesity and neurodegenerative disorders [2][3][4][5][6][7]. In this regard, EA may be a useful adjunct in Parkinson's disease treatment, as it proved to protect dopamine from oxidation and, by reducing inflammation and oxidative stress, to exert a neuroprotective effect [8].…”

SITOTOKSISITAS KOMBINASI EKSTRAK DAUN PETAI CINA DAN KULIT JENGKOL TERHADAP SEL KANKER PAYUDARA DAN SERVIKS (Cytotoxicity of Petai Cina Leaves and Jengkol Pods Combinations Against Breast Cancer Cells and Cervix)

“…Senyawa tanin seperti (-) epigalokatekin-3-galatberpotensi sebagai antikanker (Cai et al, 2016), dengan bekerja pada tingkat sel dengan memblokade fase S atau Sintesis dari siklus sel. Sel akan melakukan sintesis DNA pada fase sintesis dan terjadi proses replikasi kromosom (Albert et al, 2008).…”