Recent Advances in Bioengineered Scaffolds for Cutaneous Wound Healing

Qin, Jianghui; Chen, Fa‐Ming; Wu, Peng; Sun, Guozhe

doi:10.3389/fbioe.2022.841583

Cited by 41 publications

(26 citation statements)

References 185 publications

(202 reference statements)

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“…Bioactive, antibacterial and pro-regenerative dermal scaffolds present a class of bioengineered, advanced, multiscale platforms in regenerative medicine [ 32 , 33 ]. These biomaterials are designed to transcend the limitations of the traditional treatment methods, enabling the restoration of the biological functions of the skin through the application of bioinspired-designed scaffolds with the powerful synergistic effect of a polymeric 3D architecture and carefully incorporated bioactive agents and cells.…”

Section: Alginate-based Hydrogels and Scaffolds For Dermal Applicationmentioning

confidence: 99%

Alginate-Based Hydrogels and Scaffolds for Biomedical Applications

et al. 2023

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Alginate is a natural polymer of marine origin and, due to its exceptional properties, has great importance as an essential component for the preparation of hydrogels and scaffolds for biomedical applications. The design of biologically interactive hydrogels and scaffolds with advanced, expected and required properties are one of the key issues for successful outcomes in the healing of injured tissues. This review paper presents the multifunctional biomedical applications of alginate-based hydrogels and scaffolds in selected areas, highlighting the key effect of alginate and its influence on the essential properties of the selected biomedical applications. The first part covers scientific achievements for alginate in dermal tissue regeneration, drug delivery systems, cancer treatment, and antimicrobials. The second part is dedicated to our scientific results obtained for the research opus of hydrogel materials for scaffolds based on alginate in synergy with different materials (polymers and bioactive agents). Alginate has proved to be an exceptional polymer for combining with other naturally occurring and synthetic polymers, as well as loading bioactive therapeutic agents to achieve dermal, controlled drug delivery, cancer treatment, and antimicrobial purposes. Our research was based on combinations of alginate with gelatin, 2-hydroxyethyl methacrylate, apatite, graphene oxide and iron(III) oxide, as well as curcumin and resveratrol as bioactive agents. Important features of the prepared scaffolds, such as morphology, porosity, absorption capacity, hydrophilicity, mechanical properties, in vitro degradation, and in vitro and in vivo biocompatibility, have shown favorable properties for the aforementioned applications, and alginate has been an important link in achieving these properties. Alginate, as a component of these systems, proved to be an indispensable factor and played an excellent “role” in the optimal adjustment of the tested properties. This study provides valuable data and information for researchers and demonstrates the importance of the role of alginate as a biomaterial in the design of hydrogels and scaffolds that are powerful medical “tools” for biomedical applications.

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Section: Alginate-based Hydrogels and Scaffolds For Dermal Applicationmentioning

confidence: 99%

Alginate-Based Hydrogels and Scaffolds for Biomedical Applications

et al. 2023

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“…Despite direct injection, ASCs can be delivered through biological scaffolds. Both pro-regenerative scaffolds and bioabsorbable scaffolds are used in cutaneous wound healing ( 71 ). The scaffolds can be built based on natural, synthetic and natural-synthetic hybrid materials ( 72 ).…”

Section: Clinical Progress Of Ascs In Treating Diabetic Woundsmentioning

confidence: 99%

Adipose-Derived Stem Cells for the Treatment of Diabetic Wound: From Basic Study to Clinical Application

et al. 2022

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Diabetic wounds significantly affect the life quality of patients and may cause amputation and mortality if poorly managed. Recently, a wide range of cell-based methods has emerged as novel therapeutic methods in treating diabetic wounds. Adipose-derived stem cells (ASCs) are considered to have the potential for widespread clinical application of diabetic wounds treatment in the future. This review summarized the mechanisms of ASCs to promote diabetic wound healing, including the promotion of immunomodulation, neovascularization, and fibro synthesis. We also review the current progress and limitations of clinical studies using ASCs to intervene in diabetic wound healing. New methods of ASC delivery have been raised in recent years to provide a standardized and convenient use of ASCs.

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“…Biologically inspired dressing material is designed to imitate the structural task of an extracellular matrix (ECM), as long as a platform for cell relocation and proliferation throughout wound curing. Casting, electrospinning, and freeze‐drying sponge preparation are among the fabrication procedures that can be used to make dressing materials 3,4 …”

Section: Introductionmentioning

confidence: 99%

“…Casting, electrospinning, and freeze-drying sponge preparation are among the fabrication procedures that can be used to make dressing materials. 3,4 Bioactive micropatterning technologies have been used to create double or triple or 3D collagen architectures that promote multidimensional tissue creation with worthy textural assets and biocompatibility. Low antigenicity, low inflammatory, strong biocompatibility, and the potential to enhance cell accessory and proliferation have all been demonstrated in synthetic collagen.…”

Section: Introductionmentioning

confidence: 99%

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Fabrication of biologically inspired electrospun collagen/silk fibroin/bioactive glass composited nanofibrous to accelerate the treatment efficiency of wound repair

Yang

Zhao

et al. 2022

International Wound Journal

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A triple-layer matrix Collagen/Silk fibroin/Bioactive glass composited Nanofibrous was fabricated by linking electrospinning and freeze-drying systems, this typical three layered composite with a nanofibrous fragment as the key (top) layer, middle portion as inferior, and a spongy porous fragment as the third (bottom) deposit to develop the synergistic effect of composite materials resultant to physical and biological performances. Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy were used to assess the final material's physicochemical properties (SEM). The triple-layer matrix had a nanofibrous and porous structure, which has qualities including high porosity, swelling, and stability, which are important in soft-tissue engineering. NIH 3 T3 fibroblast and humanoid keratinocyte (HaCaT) cell lines were also used to investigate the matrix's in vitro biological and fluorescent capabilities, which showed excellent cell adherence and proliferation across the composite layers. The synergistic arrangement of nanofibrous substantial deposition onto collagenous with silk fibroin candidates has therefore proven effective in the construction of a tri-layer matrix for skintissue-engineering applications. K E Y W O R D S bioactive glass, collagen, electrospun, silk fibroin, tri-layer composite, wound repair antibacterial Key Messages • collagen (COL) and Silk fibroin (SF) prepared from fish scale and silkworm cocoons • COL:SF successfully introduced into Bioactive glass(BG) for COL:SF:BG trilayer electrospun composite Minlie Yang and Shun Yu are first author contributions.

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Recent Advances in Bioengineered Scaffolds for Cutaneous Wound Healing

Cited by 41 publications

References 185 publications

Alginate-Based Hydrogels and Scaffolds for Biomedical Applications

Alginate-Based Hydrogels and Scaffolds for Biomedical Applications

Adipose-Derived Stem Cells for the Treatment of Diabetic Wound: From Basic Study to Clinical Application

Fabrication of biologically inspired electrospun collagen/silk fibroin/bioactive glass composited nanofibrous to accelerate the treatment efficiency of wound repair

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