Recent Advances in Bioionic Liquids and Biocompatible Ionic Liquid‐Based Microemulsions

Kundu, Kaushik; Paul, Bidyut K.; Bardhan, Soumik; Saha, Swapan K.

doi:10.1002/9781118854501.ch20

Cited by 4 publications

(1 citation statement)

References 220 publications

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“…[6] This class of solvents has some IL-like solvent properties such as low melting point and volatility, high thermal stability and solubility, and finetuned physicochemical properties by choosing appropriate DES components. [7][8][9] Interestingly, a great range of DESs components are present in nature and are easily prepared by several approaches. DESs can be considered as a greener alternative compared to ILs, accom-panied with interesting advantages: Low cost, higher purity and biodegradability, and potential low toxicity.…”

Section: Introductionmentioning

confidence: 99%

Deep Eutectic Solvents: An Eco‐friendly Design for Drug Engineering

et al. 2023

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In the spirit of circular economy and sustainable chemistry, the use of environmentally friendly chemical products in pharmacy has become a hot topic. In recent years, organic solvents have been the subject of a great range of restriction policies due to their harmful effects on the environment and toxicity to human health. In parallel, deep eutectic solvents (DESs) have emerged as suitable greener solvents with beneficial environmental impacts and a rich palette of physico‐chemical advantages related to their low cost and biocompatibility. Additionally, DESs can be accompanied by a remarkable solubilizing effect for several active pharmaceutical ingredients (APIs), thus forming therapeutic DESs (TheDESs). In this work, special attention is paid to DESs, presenting a precise definition, classification, methods of preparation, and characterization. A description of natural DESs (NaDESs), i.e., eutectic solvents present in natural sources, is also reported. Moreover, the present review article is the first one to detail the different approaches for judiciously selecting the constituents of DESs in order to minimize the number of experiments. The role of DESs in the biomedical and pharmaceutical sectors and their impact on the development of successful therapies are also discussed.

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