Recent Advances in Biological Active Sulfonamide based Hybrid Compounds Part C: Multicomponent Sulfonamide Hybrids

Abstract

Sulfonamides, with the general formula R-SO2NR1R2, have attracted great attention since the early discovery of sulfonamide-containing antibacterial drugs. The combinations of certain sulfonamides and other drug molecules to form sulfonamide hybrids are being used to develop novel formulations with greater effectiveness and in a huge range of therapeutic applications such as antimicrobial, antifungal, anti-inflammatory, antitubercular, antiviral, antidiabetic, antiproliferative, carbonic anhydrase inhibitor, antimalarial, anticancer and other medicinal agents. Part C of this review presents recent advances in designing and developing multicomponent sulfonamide hybrids containing more than one biologically active heterocycle, such as coumarin, indole, pyridine, pyrimidine, pyrazole, triazole, oxazole, oxadiazole, triazine, quinazoline, and thiadiazol. This review aims to highlight the status of the hybridization technique in synthesizing biological and computational studies of novel sulfonamide hybrids that were designed and presented between 2016 and 2020.

High Inhibition for a CoII Tetrazole Bi‐pyrazole Dinuclear Complex against Fusarium Oxysporum f. sp. Albedinis

“…R f 0.57 (Ethyl acetate/silica). 1 H NMR (300 MHz, DMSO-d 6 , δ (ppm)): 12.45 (s, 1H, NH); 6.11 (dd, 1H, pz-H); 5.97 (s, 1H, pz-H); 2.36 (s, 3H, À CH 3 ); 2.25 (s, 3H, À CH 3 ); 2.14 (s, 3H, À CH 3 ). 13…”

“…R f 0.67 (ethyl acetate/silica). 1 H NMR (300 MHz, DMSO-d 6 , δ (ppm)): 6.29 (d, J = 0.8 Hz, 1H, pz-H); 6.01 (s, 1H, pz-H); 5.42 (s, 2H, CH 2 À CN); 2.39 (d, J = 0.7 Hz, 3H, À CH 3 ); 2.33 (d, J = 0.7 Hz, 3H, À CH 3 ); 2.14 (s, 3H, À CH 3 ).…”

“…Pyrazole-based precursors have raised great interest due to their use in a variety of fields with broad socio economic implications, such as pharmaceutics and biology, catalysis, corrosion inhibition, [1][2][3] and environmental studies. [4][5][6][7] The incorporation of a tetrazole ring to produce a pyrazole-tetrazole platform can lead to a variety of applications, based on medicinal chemistry, [8,9] catalysis, [10] energetic materials, [11,12] magnetism, [13] spin crossover, [14] chemical sensing, [15,16] luminescent properties, [17] to name but a few.…”

“…In an effort to investigate the coordinative ability and the effect on the structural morphology of produced molecular species, a new family of coordination compounds with selected first row transition metals was prepared by designing two new ligands, L1 and HL2 (Scheme 1), that incorporate both pyrazole and tetrazole rings (Scheme 2 and 3). Single crystal X-ray diffraction allowed to isolate the following complexes: [Ni-(L1) 3 ](ClO 4 ) 2 (1), [Cd(L1) 2 Cl 2 ] (2), [Cu(HL2)(L2)]ClO 4 (3), [Cu(L2) 2 ] (4) and [Co 2 (HL2)(L2)Cl 3 ] (5). Hirshfeld surface analyses were performed for 1-5 to evaluate in much detail the distribution of hydrogen bonds and intermolecular interactions in the crystal structures.…”

Green and rapid and instrumental one-pot method for the synthesis of imidazolines having potential anti-SARS-CoV-2 main protease activity

“…In recent studies, imidazolines and their derivatives have been found to possess several medicinal properties, such vasodepressor activity ( Ernsberger et al, 1997 ), antihistaminic effects ( Ren and Cai, 2008 ), α-adrenergic inhibition ( Yokota et al, 2013 ), antitumor activity ( Qin et al, 2015 ), histamine-like effects ( Krasavin, 2015 ), cholinomimetic activity ( Jakubowski et al, 2020 ), anti-inflammatory effects ( Regunathan et al, 1999 ), sympathomimetic effects ( Scholz, 1945 ), antinociceptive effects ( Aglawe et al, 2014 ), antioxidant effects ( Faillace et al, 2020 ), and anticancer activities ( Ghomashi et al, 2022 ) making them useful in pharmaceutical applications. Therefore, the synthesis of imidazolines and their role in treating acute and dangerous diseases such as COVID-19 could be highly significant and effective.…”