Recent Advances in Biosensor Technologies for Point-of-Care Urinalysis

Hwang, Chuljin; Lee, Won‐June; Kim, Su Dong; Park, SungJun; Kim, Joo Hee

doi:10.3390/bios12111020

Cited by 22 publications

(13 citation statements)

References 116 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Biosensors are useful tools for detecting viruses for medical purposes, offering ease and reducing costs required for circuit tests and the length of the incubation process . They work based on signal transduction and comprise three key components: a biorecognition element, a transducer, and an electronic system. , Biorecognition elements as receptors interact with specific analytes, and many modifications have been developed to improve the physicochemical performance of the sensing layer on different dimensional nanomaterials .…”

Section: General Overview Of Mosquito-borne Virusesmentioning

confidence: 99%

Peptide-Based Flavivirus Biosensors: From Cell Structure to Virological and Serological Detection Methods

Muslihati,

Septiani,

Gumilar

et al. 2024

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

In tropical and developing countries, mosquito-borne diseases by flaviviruses pose a serious threat to public health. Early detection is critical for preventing their spread, but conventional methods are time-consuming and require skilled technicians. Biosensors have been developed to address this issue, but cross-reactivity with other flaviviruses remains a challenge. Peptides are essentially biomaterials used in diagnostics that allow virological and serological techniques to identify flavivirus selectively. This biomaterial originated as a small protein consisting of two to 50 amino acid chains. They offer flexibility in chemical modification and can be easily synthesized and applied to living cells in the engineering process. Peptides could potentially be developed as robust, low-cost, sensitive, and selective receptors for detecting flaviviruses. However, modification and selection of the receptor agents are crucial to determine the effectiveness of binding between the targets and the receptors. This paper addresses two potential peptide nucleic acids (PNAs) and affinity peptides that can detect flavivirus from another target-based biosensor as well as the potential peptide behaviors of flaviviruses. The PNAs detect flaviviruses based on the nucleotide base sequence of the target's virological profile via Watson−Crick base pairing, while the affinity peptides sense the epitope or immunological profile of the targets. Recent developments in the functionalization of peptides for flavivirus biosensors are explored in this Review by division into electrochemical, optical, and other detection methods.

show abstract

Section: General Overview Of Mosquito-borne Virusesmentioning

confidence: 99%

Peptide-Based Flavivirus Biosensors: From Cell Structure to Virological and Serological Detection Methods

Muslihati,

Septiani,

Gumilar

et al. 2024

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

show abstract

“…Urinalysis is commonly performed using traditional methods such as urine culture, urine microscopy, and dipstick tests. The dipstick test, in particular, is widely used due to its ease of use, quick response time, and low cost [ 165 ]. In this test the dipstick is immersed in the urine sample, which will react with the chemical reagents present in each one of the pads of the plastic strip, causing a colour change that is compared to a colour chart on the dipstick container.…”

Section: Point-of-care Diagnostics: Urinalysismentioning

confidence: 99%

Urinary Biomarkers and Point-of-Care Urinalysis Devices for Early Diagnosis and Management of Disease: A Review

Sequeira-Antunes

Ferreira

2023

Biomedicines

View full text Add to dashboard Cite

Biosensing and microfluidics technologies are transforming diagnostic medicine by accurately detecting biomolecules in biological samples. Urine is a promising biological fluid for diagnostics due to its noninvasive collection and wide range of diagnostic biomarkers. Point-of-care urinalysis, which integrates biosensing and microfluidics, has the potential to bring affordable and rapid diagnostics into the home to continuing monitoring, but challenges still remain. As such, this review aims to provide an overview of biomarkers that are or could be used to diagnose and monitor diseases, including cancer, cardiovascular diseases, kidney diseases, and neurodegenerative disorders, such as Alzheimer’s disease. Additionally, the different materials and techniques for the fabrication of microfluidic structures along with the biosensing technologies often used to detect and quantify biological molecules and organisms are reviewed. Ultimately, this review discusses the current state of point-of-care urinalysis devices and highlights the potential of these technologies to improve patient outcomes. Traditional point-of-care urinalysis devices require the manual collection of urine, which may be unpleasant, cumbersome, or prone to errors. To overcome this issue, the toilet itself can be used as an alternative specimen collection and urinalysis device. This review then presents several smart toilet systems and incorporated sanitary devices for this purpose.

show abstract

“…Considering future medical technologies, nanoparticles (NPs) will be central to developing new sensing devices because of their extremely small dimensions in the nanometer (nm) range, wide availability (found in nature or laboratory manufactured) and electrochemical properties [105,106].…”

Section: Challenges and Perspectives Of Uric Acid Electrochemical Det...mentioning

confidence: 99%

New Trends in Uric Acid Electroanalysis

Chelmea,

Badea,

Scarneciu

et al. 2023

Chemosensors

View full text Add to dashboard Cite

Considering the increasing incidence of hyperuricemia and oxidative stress-related diseases, quantification of uric acid has become essential. Therefore, the evolution on sensing devices being favorable, these questions are more often addressed to the field of medical researchers. As for many metabolites, (bio)sensors provide a reliable method for screening and evaluation of uric acid status. Due to the numerous categories of (bio)sensors available, choosing the appropriate one is a challenge. This study reviews the scientific information concerning the most suitable (bio)sensors for quantification of uric acid, presenting a list of sensors from the last decade, categorized by configurations and materials. In addition, this review includes a comparison of sensors according to their interference behavior and sensitivity, offering an objective perspective for identifying devices that are suitable for clinical applications.

show abstract

Recent Advances in Biosensor Technologies for Point-of-Care Urinalysis

Cited by 22 publications

References 116 publications

Peptide-Based Flavivirus Biosensors: From Cell Structure to Virological and Serological Detection Methods

Peptide-Based Flavivirus Biosensors: From Cell Structure to Virological and Serological Detection Methods

Urinary Biomarkers and Point-of-Care Urinalysis Devices for Early Diagnosis and Management of Disease: A Review

New Trends in Uric Acid Electroanalysis

Contact Info

Product

Resources

About