Recent advances in cellulose microgels: Preparations and functionalized applications

Yang, Yang; Sha, Lishan; Zhao, Han; Guo, Zhenchao; Wu, Min; Lü, Peng

doi:10.1016/j.cis.2022.102815

Cited by 18 publications

(6 citation statements)

References 155 publications

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“…[19] Cells within the hydrogel matrix switch these cues into biochemical signals, and this complex array of extracellular signals then initiates intracellular signaling cascades and ultimately converts them into cellular responses, including migration, proliferation, and differentiation. [12,20] In consequence, changes in the specific physicochemical properties of hydrogels can affect signaling pathways and cellular behavior, which further affect their ability to perform their functions. These properties include stiffness, swelling ability, porous structure, viscoelasticity, and biodegradability (as shown in Figure 1).…”

Section: The Classification and Physicochemical Properties Of Hydrogelsmentioning

confidence: 99%

Hydrogel‐Based Systems in Neuro‐Vascularized Bone Regeneration: A Promising Therapeutic Strategy

Li,

Cui,

et al. 2024

Macromolecular Bioscience

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Blood vessels and nerve fibers are distributed throughout the skeletal tissue, which enhance the development and function of each other and have an irreplaceable role in bone formation and remodeling. Despite significant progress in bone tissue engineering, the inadequacy of nerve‐vascular network reconstruction remains a major limitation. This is partly due to the difficulty of integrating and regulating multiple tissue types with artificial materials. Thus, understanding the anatomy and underlying coupling mechanisms of blood vessels and nerve fibers within bone to further develop neuro‐vascularized bone implant biomaterials is an extremely critical aspect in the field of bone regeneration. Hydrogels have good biocompatibility, controllable mechanical characteristics, and osteoconductive and osteoinductive properties, making them important candidates for research related to neuro‐vascularized bone regeneration. This review reports the classification and physicochemical properties of hydrogels, with a focus on the application advantages and status of hydrogels for bone regeneration. We also highlight the effect of neurovascular coupling on bone repair and regeneration and the necessity of achieving neuro‐vascularized bone regeneration. Finally, the recent progress and design strategies of hydrogel‐based biomaterials for neuro‐vascularized bone regeneration are discussed.This article is protected by copyright. All rights reserved

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Section: The Classification and Physicochemical Properties Of Hydrogelsmentioning

confidence: 99%

Hydrogel‐Based Systems in Neuro‐Vascularized Bone Regeneration: A Promising Therapeutic Strategy

Li,

Cui,

et al. 2024

Macromolecular Bioscience

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“…[ 235 ] As a linear polysaccharide derived from plants, cellulose boasts prominent advantages such as high mechanical strength, chemical structural stability, good biocompatibility, biodegradability, renewability, wide availability, and abundant reserves. [ 236 ] Furthermore, the abundant hydroxyl groups on the cellulose molecular chain provide the potential for the preparation of various functional hydrogels through chemical modifications, which helps cellulose to play a significant role in the preparation of hydrogels. [ 236 ]…”

Section: Materials For Hydrogel Microspheresmentioning

confidence: 99%

Nano‐Micron Combined Hydrogel Microspheres: Novel Answer for Minimal Invasive Biomedical Applications

Liu,

Du,

Chen

et al. 2024

Macromol. Rapid Commun.

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Hydrogels, key in biomedical research for their hydrophilicity and versatility, have evolved with hydrogel microspheres (HMs) of micron‐scale dimensions, enhancing their role in minimally invasive therapeutic delivery, tissue repair, and regeneration. The recent emergence of nanomaterials has ushered in a revolutionary transformation in the biomedical field, which demonstrates tremendous potential in targeted therapies, biological imaging, and disease diagnostics. Consequently, the integration of advanced nanotechnology promises to trigger a new revolution in the realm of hydrogels. HMs loaded with nanomaterials combine the advantages of both hydrogels and nanomaterials, which enables multifaceted functionalities such as efficient drug delivery, sustained release, targeted therapy, biological lubrication, biochemical detection, medical imaging, biosensing monitoring, and micro‐robotics. Here, this review comprehensively expounds upon commonly used nanomaterials and their classifications. Then, it provides comprehensive insights into the raw materials and preparation methods of HMs. Besides, the common strategies employed to achieve nano‐micron combinations are summarized, and the latest applications of these advanced nano‐micron combined HMs in the biomedical field are elucidated. Finally, valuable insights into the future design and development of nano‐micron combined HMs are provided.

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“…Various methods for preparing microgels are available, including emulsification, precipitation, extrusion, and sprayassisted techniques. 19,20 Overall, spray-assisted techniques such as spray drying offer several advantages over other techniques such as scalability, reproducibility, and simplicity. 21−23 In spray drying, microgels can be cross-linked in situ during the drying process by simultaneously spraying a polymer with a crosslinker (e.g., epichlorohydrin and glutaraldehyde).…”

Section: ■ Introductionmentioning

confidence: 99%

“…Various methods for preparing microgels are available, including emulsification, precipitation, extrusion, and spray-assisted techniques. , Overall, spray-assisted techniques such as spray drying offer several advantages over other techniques such as scalability, reproducibility, and simplicity. − In spray drying, microgels can be cross-linked in situ during the drying process by simultaneously spraying a polymer with a cross-linker (e.g., epichlorohydrin and glutaraldehyde). However, these cross-linkers are often volatile and can be rapidly lost during the drying process, which results in a low cross-linking efficiency. , Furthermore, these cross-linkers are toxic and/or carcinogenic, which poses environmental and health risks when sprayed in large quantities.…”

Section: Introductionmentioning

confidence: 99%

Transforming Sand into Arable Substrate Using Biobased Microgels to Improve Land Productivity

Escayo,

Mondarte,

et al. 2024

ACS Appl. Polym. Mater.

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Crop cultivation in coarse sand poses challenges due to its poor water-holding capacity, and as a consequence, such substrate is poor in holding nutrients necessary to support crop growth. The use of swellable microgel as a soil conditioner can enhance the hydraulic properties of sand, which may lead to better plant growth performance despite the inherent poor water-holding ability of sand. This study explores the use of a highly swellable microgel based on Ca2+-cross-linked carboxymethyl cellulose (CMC)/alginate for water retention and conditioning of the substrate–coarse sand. The microgel was spray-dried, resulting in spherical particles with an average diameter of ∼2 μm. The swelling ratio (SR) of the microgel was found to be dependent on the CMC:alginate mass ratio and displayed pH-responsive properties due to the ionizability of the −COOH groups. Displacement of Ca2+-alginate cross-link by nongelling ions (i.e., Na+, Mg2+) resulted in greater swelling but reduced the mechanical stability of the microgel. It was found that 0.1–0.5% (w/w) microgel addition in coarse sand greatly enhanced the water-holding and retention properties of the substrate. With this addition of microgels in sand, there is further enhancement in the survival and growth of Amaranthus tricolor seedlings during well-watered and drought conditions. These findings suggest the potential of Ca2+-cross-linked CMC/alginate microgels as a water retention agent and conditioner for coarse and dry substrates, hence providing the opportunity to expand the land available for agriculture.

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Recent advances in cellulose microgels: Preparations and functionalized applications

Cited by 18 publications

References 155 publications

Hydrogel‐Based Systems in Neuro‐Vascularized Bone Regeneration: A Promising Therapeutic Strategy

Hydrogel‐Based Systems in Neuro‐Vascularized Bone Regeneration: A Promising Therapeutic Strategy

Nano‐Micron Combined Hydrogel Microspheres: Novel Answer for Minimal Invasive Biomedical Applications

Transforming Sand into Arable Substrate Using Biobased Microgels to Improve Land Productivity

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