Recent Advances in Chemistry Technologies and Applications to Medicinal Chemistry

Abstract

Successful drug discovery is a team sport, wherein several disciplines contribute customized scholarship toward the common goal of delivering medications that can have a remarkable impact on patients' lives. In the realm of medicinal chemistry, there have been significant advances in molecular‐/structure‐based design, organic synthesis, and chemistry technologies, the interplay of all of which can have a significant impact on reducing cycle times, cost of goods, and improving the probability of technical success of drug discovery. This article covers the evolution and application of some of the newer chemistry technologies in medicinal chemistry.

Commercial-Scale Visible Light Trifluoromethylation of 2-Chlorothiophenol Using CF3I Gas

“…The use of photochemistry can transform the way the active pharmaceutical ingredients are manufactured. − The last decade has seen widespread publication of new visible-light-mediated transformations. Medicinal chemistry quickly adapted and applied these transformations, and their use has become common. − However, uptake of these new methodologies in process chemistry has lagged due to significant challenges associated with scaling light sources and related limitations of the Beer–Lambert law . Despite these challenges, the appeal of the photochemical-based transformations remains undeniable, and industrial commitments to green chemistry and efficient processing demanded a functional solution.…”