Recent Advances in Continuous‐Flow Enantioselective Catalysis

Abstract

The increased demand for more efficient, safe, and green production in fine chemical and pharmaceutical industry calls for the development of continuous-flowm anufacturing, and for chiral chemicals in particular,e nantioselective catalytic processes. In recenty ears, this emerging direction has received considerable attention and has seen rapid progress. In most cases, catalytic enantioselective flow processes using homogeneous, heterogeneous, or enzymatic catalysts have shown significant advantages over the conventional batch mode,s uch as shortened reaction times, lower catalysts loadings, andh igher selectivities in addition to the normalm erits of non-enantioselective flow operations. In this Minireview,t he advancements, key strategies, methods, and technologiesd eveloped the last six years as well as remaining challenges are summarized.[a] T.

Immobilization of Arabidopsis thaliana Hydroxynitrile Lyase (AtHNL) on EziG Opal

“…Enzyme catalyzed reactions in flow are gaining attention due to improved productivity, easier downstream processing and efficiency of scale-up compared to batch systems. Reduced reaction times and enhanced selectivity are reported benefits of performing reactions in flow [23][24][25][26]. On top of all these benefits mentioned before, continuous flow reactions allow to optimize resource utilization, reduce reaction volumes and consequently achieve waste reductions and lower energy consumption [27].…”

The rise of continuous flow biocatalysis – fundamentals, very recent developments and future perspectives

“…What should not be forgotten in this context are the recently published excellent review articles dealing with 'flow chemistry' in general. [21][22][23][24][25][26][27][28][29] In addition, to make it clearer, we have briefly listed recent reviews and their core interests: a review from Yu et al is about continuous flow enantioselective catalysis, 30 a publication by Noël and co-workers describes the field of continuous flow photochemistry in organic synthesis, material science, and water treatment photo flux catalysis, 31 and a review written by Power et al 32 is available about organolithium bases in flow chemistry.…”

Immobilisation and flow chemistry: tools for implementing biocatalysis

“…25 These reactors further reduce reaction time as consequence of the large surface to volume ratio, high thermal efficiency and improved safety. 53,54 In addition, mass transfer is enhanced due to its hierarchical/tortuous porous structure reducing diffusion limitation. 55 Possible disadvantages are the higher costs compared to packed bed systems and the difficulty to scale up.…”