Recent Advances in Crosslinked Nanogel for Multimodal Imaging and Cancer Therapy

Zhou, Wen; Yang, Gang; Ni, Xiaoyue; Diao, Shanchao; Xie, Chen; Fan, Quli

doi:10.3390/polym12091902

Cited by 18 publications

(6 citation statements)

References 106 publications

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“…To achieve precise and personalized therapeutic efficiency, diagnostic methods are in high demand for real‐time monitoring of the therapeutic process. [ 226 ] In the following, diagnostic and theranostic microgel systems in preclinical trials are presented and their potential for application in patients is discussed (see Table 4 for a list of applications and trials).…”

Section: Clinical Applicationsmentioning

confidence: 99%

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Translating Therapeutic Microgels into Clinical Applications

Kittel

Kuehne

Laporte

2021

Adv Healthcare Materials

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Microgels are crosslinked, water‐swollen networks with a 10 nm to 100 µm diameter and can be modified chemically or biologically to render them biocompatible for advanced clinical applications. Depending on their intended use, microgels require different mechanical and structural properties, which can be engineered on demand by altering the biochemical composition, crosslink density of the polymer network, and the fabrication method. Here, the fundamental aspects of microgel research and development, as well as their specific applications for theranostics and therapy in the clinic, are discussed. A detailed overview of microgel fabrication techniques with regards to their intended clinical application is presented, while focusing on how microgels can be employed as local drug delivery materials, scavengers, and contrast agents. Moreover, microgels can act as scaffolds for tissue engineering and regeneration application. Finally, an overview of microgels is given, which already made it into pre‐clinical and clinical trials, while future challenges and chances are discussed. This review presents an instructive guideline for chemists, material scientists, and researchers in the biomedical field to introduce them to the fundamental physicochemical properties of microgels and guide them from fabrication methods via characterization techniques and functionalization of microgels toward specific applications in the clinic.

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Section: Clinical Applicationsmentioning

confidence: 99%

“…[225] Such theranostic microgel systems for targeted cancer diagnosis and therapy have gained increasing attention in recent years. [226]…”

Section: Microgels For Imaging and Diagnosticsmentioning

confidence: 99%

Translating Therapeutic Microgels into Clinical Applications

Kittel

Kuehne

Laporte

2021

Adv Healthcare Materials

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“…However, using expensive techniques for preparing some NGs and removing solvents and surfactants from final products are disadvantages of such systems ( Zhou et al, 2020 ).…”

Section: Nanogelsmentioning

confidence: 99%

Physically stimulus-responsive nanoparticles for therapy and diagnosis

et al. 2022

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Nanoparticles offer numerous advantages in various fields of science, particularly in medicine. Over recent years, the use of nanoparticles in disease diagnosis and treatments has increased dramatically by the development of stimuli-responsive nano-systems, which can respond to internal or external stimuli. In the last 10 years, many preclinical studies were performed on physically triggered nano-systems to develop and optimize stable, precise, and selective therapeutic or diagnostic agents. In this regard, the systems must meet the requirements of efficacy, toxicity, pharmacokinetics, and safety before clinical investigation. Several undesired aspects need to be addressed to successfully translate these physical stimuli-responsive nano-systems, as biomaterials, into clinical practice. These have to be commonly taken into account when developing physically triggered systems; thus, also applicable for nano-systems based on nanomaterials. This review focuses on physically triggered nano-systems (PTNSs), with diagnostic or therapeutic and theranostic applications. Several types of physically triggered nano-systems based on polymeric micelles and hydrogels, mesoporous silica, and magnets are reviewed and discussed in various aspects.

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“…And it is easy to synthesize and functionalize, is controllable in size, and has efficient drug loading capacity and good stability ( Li et al, 2021b ). According to the favorable characteristics, NG can be utilized as an ideal medical nanocarrier, which can integrate targeted molecules ( Liang et al, 2016 ; Yang et al, 2019 ), therapeutic drugs ( Peng et al, 2020 ; Li et al, 2021 ; Wang et al, 2021 ) and imaging reagents ( Theune et al, 2019 ; Zhou et al, 2020 ) into one nanosystem.…”

Section: Introductionmentioning

confidence: 99%

Phenylboronic acid conjugated multifunctional nanogels with 131I-labeling for targeted SPECT imaging and radiotherapy of breast adenocarcinoma

Kong

Zhu²,

Su³

et al. 2022

Front. Bioeng. Biotechnol.

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We report a new 131I-labeling functional platform for targeted single-photon emission computed tomography (SPECT) imaging and radiotherapy of breast adenocarcinoma. In this study, polyethyleneimine (PEI) based nanogels (P.NH2 NGs) were prepared by water/oil polymerization, modified with targeted agent phenylboronic acid (PBA), and labeled with radionuclide 131I. The NGs without 131I-labeling own a spherical structure, uniform size distribution, and good cell viability. After 131I-labeling, the obtained 131I-PBA-PHP NGs displayed much higher cellular uptake than the non-targeted NGs due to the good softness and fluidity of NGs and the PBA targeting. The in vivo results demonstrated that 131I-PBA-PHP NGs could specifically target breast cancer cells and efficiently aggregate into xenograft breast adenocarcinoma for tumor SPECT imaging and specific radiotherapy. The developed 131I-labeling NGs may be used as a promising platform for efficient radioactive theranostic nanoplatform of tumor.

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Recent Advances in Crosslinked Nanogel for Multimodal Imaging and Cancer Therapy

Cited by 18 publications

References 106 publications

Translating Therapeutic Microgels into Clinical Applications

Translating Therapeutic Microgels into Clinical Applications

Physically stimulus-responsive nanoparticles for therapy and diagnosis

Phenylboronic acid conjugated multifunctional nanogels with 131I-labeling for targeted SPECT imaging and radiotherapy of breast adenocarcinoma

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