Recent advances in developing butyrogenic functional foods to promote gut health

Zhang, Miao; Li, Robert W.; Yang, Han–Soeb; Tan, Zhongfang; Liu, Fang

doi:10.1080/10408398.2022.2142194

Cited by 12 publications

(10 citation statements)

References 153 publications

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“…Consistently, P. pentosaceus YC administration raised the abundance of Firmicutes, Fusobacteria, Bacteroidetes phyla and Lactobacillus , Cetobacterium , and Bacteroides genera. These bacteria are capable of effectively producing SCFAs, which can help to repair intestinal barrier damage [ 63 – 65 ]. The metabolites analysis further indicated that the addition of P. pentosaceus YC increased the level of propionate significantly.…”

Section: Discussionmentioning

confidence: 99%

Probiotic Pediococcus pentosaceus restored gossypol-induced intestinal barrier injury by increasing propionate content in Nile tilapia

Ding,

Zhou,

Luo

et al. 2024

J Animal Sci Biotechnol

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Background Intestinal barrier is a dynamic interface between the body and the ingested food components, however, dietary components or xenobiotics could compromise intestinal integrity, causing health risks to the host. Gossypol, a toxic component in cottonseed meal (CSM), caused intestinal injury in fish or other monogastric animals. It has been demonstrated that probiotics administration benefits the intestinal barrier integrity, but the efficacy of probiotics in maintaining intestinal health when the host is exposed to gossypol remains unclear. Here, a strain (YC) affiliated to Pediococcus pentosaceus was isolated from the gut of Nile tilapia (Oreochromis niloticus) and its potential to repair gossypol-induced intestinal damage was evaluated. Results A total of 270 Nile tilapia (2.20 ± 0.02 g) were allotted in 3 groups with 3 tanks each and fed with 3 diets including CON (control diet), GOS (control diet containing 300 mg/kg gossypol) and GP (control diet containing 300 mg/kg gossypol and 108 colony-forming unit (CFU)/g P. pentosaceus YC), respectively. After 10 weeks, addition of P. pentosaceus YC restored growth retardation and intestinal injury induced by gossypol in Nile tilapia. Transcriptome analysis and siRNA interference experiments demonstrated that NOD-like receptors (NLR) family caspase recruitment domain (CARD) domain containing 3 (Nlrc3) inhibition might promote intestinal stem cell (ISC) proliferation, as well as maintaining gut barrier integrity. 16S rRNA sequencing and gas chromatography-mass spectrometry (GC-MS) revealed that addition of P. pentosaceus YC altered the composition of gut microbiota and increased the content of propionate in fish gut. In vitro studies on propionate’s function demonstrated that it suppressed nlrc3 expression and promoted wound healing in Caco-2 cell model. Conclusions The present study reveals that P. pentosaceus YC has the capacity to ameliorate intestinal barrier injury by modulating gut microbiota composition and elevating propionate level. This finding offers a promising strategy for the feed industry to incorporate cottonseed meal into fish feed formulations. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

Probiotic Pediococcus pentosaceus restored gossypol-induced intestinal barrier injury by increasing propionate content in Nile tilapia

Ding,

Zhou,

Luo

et al. 2024

J Animal Sci Biotechnol

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“…Additionally, butyrate induces the expansion of Tregs, and enhances the expression of IL-10 and IL-18 by activating GPR109A on macrophages and DCs ( 101 , 102 ). It is well-established that the breakdown of the intestinal mucosal barrier contributes to the development of CRC, and butyrate can enhance intestinal barrier function by activating GPCRs ( 103 ). On one hand, the combination of butyrate and GPR109A activates K + outflow, leading to cell hyperpolarization.…”

Section: Mechanisms Of Butyrate's Biological Functions In Tumormentioning

confidence: 99%

Butyrate as a promising therapeutic target in cancer: From pathogenesis to clinic (Review)

Sun,

Chen,

Zang

et al. 2024

Int J Oncol

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Cancer is one of the leading causes of mortality worldwide. The etiology of cancer has not been fully elucidated yet, and further enhancements are necessary to optimize therapeutic efficacy. Butyrate, a short-chain fatty acid, is generated through gut microbial fermentation of dietary fiber. Studies have unveiled the relevance of butyrate in malignant neoplasms, and a comprehensive understanding of its role in cancer is imperative for realizing its full potential in oncological treatment. Its full antineoplastic effects via the activation of G protein-coupled receptors and the inhibition of histone deacetylases have been also confirmed. However, the underlying mechanistic details remain unclear. The present study aimed to review the involvement of butyrate in carcinogenesis and its molecular mechanisms, with a particular emphasis on its association with the efficacy of tumor immunotherapy, as well as discussing relevant clinical studies on butyrate as a therapeutic target for neoplastic diseases to provide new insights into cancer treatment.

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“…It can not only serve as an energy source for normal colonocytes, but also reduce the risk of CRC. 227 It is well known that the destruction of intestinal mucosal barrier acts as an accomplice in the occurrence of CRC, while butyrate can repair and enhance the function of the gut barrier. 228 Peng et al demonstrated that one of the specific mechanisms by which butyrate enhances the intestinal barrier is to promote the assembly of tight junctions through activating AMP-Activated Protein Kinase.…”

Section: Cancer-related Microorganisms and Effectorsmentioning

confidence: 99%

Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications

Zhao

Mei

et al. 2023

Sig Transduct Target Ther

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In the past period, due to the rapid development of next-generation sequencing technology, accumulating evidence has clarified the complex role of the human microbiota in the development of cancer and the therapeutic response. More importantly, available evidence seems to indicate that modulating the composition of the gut microbiota to improve the efficacy of anti-cancer drugs may be feasible. However, intricate complexities exist, and a deep and comprehensive understanding of how the human microbiota interacts with cancer is critical to realize its full potential in cancer treatment. The purpose of this review is to summarize the initial clues on molecular mechanisms regarding the mutual effects between the gut microbiota and cancer development, and to highlight the relationship between gut microbes and the efficacy of immunotherapy, chemotherapy, radiation therapy and cancer surgery, which may provide insights into the formulation of individualized therapeutic strategies for cancer management. In addition, the current and emerging microbial interventions for cancer therapy as well as their clinical applications are summarized. Although many challenges remain for now, the great importance and full potential of the gut microbiota cannot be overstated for the development of individualized anti-cancer strategies, and it is necessary to explore a holistic approach that incorporates microbial modulation therapy in cancer.

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Recent advances in developing butyrogenic functional foods to promote gut health

Cited by 12 publications

References 153 publications

Probiotic Pediococcus pentosaceus restored gossypol-induced intestinal barrier injury by increasing propionate content in Nile tilapia

Probiotic Pediococcus pentosaceus restored gossypol-induced intestinal barrier injury by increasing propionate content in Nile tilapia

Butyrate as a promising therapeutic target in cancer: From pathogenesis to clinic (Review)

Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications

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