2024
DOI: 10.1002/ajoc.202400528
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Recent Advances in Direct Amidation Via Organocatalysis

Mohanad A. Hussein,
Ahmed Hassoon Mageed

Abstract: The formation of amide bonds is essential for a wide range of applications in biological and organic systems, including proteins, pesticides, polymers, and pharmaceuticals. Moreover, it plays a critical role in the synthesis of numerous bioactive compounds with anticancer, antibacterial, and antifungal properties. Due to the limitations of conventional coupling reagents for amide synthesis, there is a growing demand for environmentally sustainable methodologies, particularly the direct formation of amides from… Show more

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