Recent advances in discovery and biosynthesis of natural products from myxobacteria: an overview from 2017 to 2023

Wang, Chao-Yi; Hu, Jia-Qi; Wang, De-Gao; Li, Yue-Zhong; Wu, Changsheng

doi:10.1039/d3np00062a

Nat. Prod. Rep.

2024

DOI: 10.1039/d3np00062a

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Recent advances in discovery and biosynthesis of natural products from myxobacteria: an overview from 2017 to 2023

Chao-Yi Wang,

Jia-Qi Hu,

De-Gao Wang

et al.

Abstract: This review presents a comprehensive overview of recent advances in the discovery methodologies, new structures, bioactivities, and unique biosynthetic logics of myxobacterial natural products reported from January 2017 to November 2023.

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Cited by 4 publications

References 232 publications

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An upgraded Myxococcus xanthus chassis with enhanced growth characteristics for efficient genetic manipulation

Hu,

Wang,

Yue

et al. 2024

Engineering Microbiology

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An upgraded Myxococcus xanthus chassis with enhanced growth characteristics for efficient genetic manipulation

Hu,

Wang,

Yue

et al. 2024

Engineering Microbiology

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MyxoPortal: a database of myxobacterial genomic features

Swetha,

Arakal,

Rajendran

et al. 2024

Database

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Myxobacteria are predatory bacteria with antimicrobial activity, utilizing complex mechanisms to kill their prey and assimilate their macromolecules. Having large genomes encoding hundreds of secondary metabolites, hydrolytic enzymes and antimicrobial peptides, these organisms are widely studied for their antibiotic potential. MyxoPortal is a comprehensive genomic database hosting 262 genomes of myxobacterial strains. Datasets included provide genome annotations with gene locations, functions, amino acids and nucleotide sequences, allowing analysis of evolutionary and taxonomical relationships between strains and genes. Biosynthetic gene clusters are identified by AntiSMASH, and dbAMP-generated antimicrobial peptide sequences are included as a resource for novel antimicrobial discoveries, while curated datasets of CRISPR/Cas genes, regulatory protein sequences, and phage associated genes give useful insights into each strain’s biological properties. MyxoPortal is an intuitive open-source database that brings together application-oriented genomic features that can be used in taxonomy, evolution, predation and antimicrobial research. MyxoPortal can be accessed at http://dicsoft1.physics.iisc.ac.in/MyxoPortal/. Database URL: http://dicsoft1.physics.iisc.ac.in/MyxoPortal/. Graphical Abstract

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Harnessing Gram‐negative bacteria for novel anti‐Gram‐negative antibiotics

Birkelbach,

Seyfert,

Walesch

et al. 2024

Microbial Biotechnology

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Natural products have proven themselves as a valuable resource for antibiotics. However, in view of increasing antimicrobial resistance, there is an urgent need for new, structurally diverse agents that have the potential to overcome resistance and treat Gram‐negative pathogens in particular. Historically, the search for new antibiotics was strongly focussed on the very successful Actinobacteria. On the other hand, other producer strains have been under‐sampled and their potential for the production of bioactive natural products has been underestimated. In this mini‐review, we highlight prominent examples of novel anti‐Gram negative natural products produced by Gram‐negative bacteria that are currently in lead optimisation or preclinical development. Furthermore, we will provide insights into the considerations and strategies behind the discovery of these agents and their putative applications.

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Recent advances in discovery and biosynthesis of natural products from myxobacteria: an overview from 2017 to 2023

Abstract: This review presents a comprehensive overview of recent advances in the discovery methodologies, new structures, bioactivities, and unique biosynthetic logics of myxobacterial natural products reported from January 2017 to November 2023.

Cited by 4 publications

References 232 publications

An upgraded Myxococcus xanthus chassis with enhanced growth characteristics for efficient genetic manipulation

An upgraded Myxococcus xanthus chassis with enhanced growth characteristics for efficient genetic manipulation

MyxoPortal: a database of myxobacterial genomic features

Harnessing Gram‐negative bacteria for novel anti‐Gram‐negative antibiotics

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