Recent advances in electrospun polycaprolactone based scaffolds for wound healing and skin bioengineering applications

Joseph, Blessy; Augustine, Robin; Kalarikkal, Nandakumar; Thomas, Sabu; Seantier, Bastien; Grohens, Yves

doi:10.1016/j.mtcomm.2019.02.009

Cited by 152 publications

(75 citation statements)

References 124 publications

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“…In addition, the difficult healing of diabetic wound is also found to be related to the excessive activity of metalloproteinases (MMPs), the impaired expression of growth and angiogenic factors (VEGF and PDGF) . Recently, many efforts have been devoted to treat diabetic wounds, for example, cerium oxide nanoparticle, titanium nanorod, silver nanoparticle, zinc oxide nanofiber, nitric oxide, and various growth factors7a were incorporated to develop advanced dressings.…”

Section: Introductionmentioning

confidence: 99%

A Multifunctional Pro‐Healing Zwitterionic Hydrogel for Simultaneous Optical Monitoring of pH and Glucose in Diabetic Wound Treatment

Zhu

Zhang

Song

et al. 2019

Adv Funct Materials

331

251

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Diabetic ulcer is the most common kind of chronic wound worldwide. Though great efforts have been devoted, diabetic ulcer still remains as a challenge that requires constant monitoring and management. In this work, a multifunctional zwitterionic hydrogel is developed to simultaneously detect two fluctuant wound parameters, pH and glucose level, to monitor the diabetic wound status. A pH indicator dye (phenol red) and two glucose sensing enzymes, glucose oxidase (GOx) and horseradish peroxidase (HRP), are encapsulated in the anti-biofouling and biocompatible zwitterionic poly-carboxybetaine (PCB) hydrogel matrix. The visible images are collected by a smartphone and transformed into RGB signals to quantify the wound parameters. Results show that the activity and stability of both two enzymes are improved within PCB hydrogel, and the K cat /K m value of PCB-HRP is ≈5.5 fold of free HRP in artificial wound exudate. This novel wound dressing can successfully monitor the pH range of 4-8 and glucose level of 0.1-10 × 10 −3 m. Meanwhile, it also provides a moist healing environment that can promote diabetic wound healing. This multifunctional wound dressing may open vistas in chronic wound management and guide the diabetes treatment in clinical applications.

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Section: Introductionmentioning

confidence: 99%

A Multifunctional Pro‐Healing Zwitterionic Hydrogel for Simultaneous Optical Monitoring of pH and Glucose in Diabetic Wound Treatment

Zhu

Zhang

Song

et al. 2019

Adv Funct Materials

331

251

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show abstract

“…[24][25][26] PCL has a slow degradation rate due to its hydrophobicity and high crystallinity. [27,28] PCL is suitable for controlling drug release, which is due to the high permeability of many drugs with excellent biocompatibility and its ability to excrete completely from the body. The biodegradability of PCL is slower than other polymers.…”

Section: Introductionmentioning

confidence: 99%

Electrospun PCL and PLA hybrid nanofibrous scaffolds containing Nigella sativa herbal extract for effective wound healing

Sharifi

Bahrami

Nejad

et al. 2020

J of Applied Polymer Sci

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Black seed (Nigella sativa [NS]) is used in traditional medicine as an antibacterial agent. In this study, novel hybrid scaffolds were manufactured from poly(ɛ‐caprolactone[PCL])/ Poly(lactic acid [PLA]) with NS extract by double‐nozzle electrospinning for wound healing application. Optimal conditions were found using response surface methodology including feed rate 0.8 ml/hr, voltage 20 kV and PLA 8% /PCL 10% concentrations. The effect of NS extract on the properties of the scaffold was evaluated by scanning electron microscopy, contact angle, and mechanical test. The PLA‐PCL/NS 20% beadles, and smooth nanofibrous web was obtained as the optimum scaffold with an average diameter of 638 ± 69 nm and the contact angle of 44°. In addition, the biological properties of the scaffolds such as antibacterial against Staphylococcus aureus (gram‐positive) and Escherichia coli (gram‐negative) bacteria, MTT assay, extract release, and cell growth (human mesenchymal stem cells) were examined. Incorporation of NS extract into the nanofibers caused to enhance the biological properties, cell viability and cell proliferation without toxicity.

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“…The surface morphologies of the fabricated are affected by several factors such as nature of the solvent, concentration, and viscosity of the solution, distance, charge density and applied voltage. [18][19][20] The fabricated scaffolds have smooth morphology without noticeable beads and thinner diameter was observed in PC scaffolds as compared to pure PCL scaffolds. A similar result was also observed by Shi et al in the presence of CNCs with the poly(lactic acid) polymer matrix.…”

Section: Morphology Of Cncsmentioning

confidence: 92%

“…An enhancement in the cell viability of PCL electrospun in the presence of nanoller has been reported earlier for tissue engineering. [16][17][18][19][20][21][22][23][24] The higher cell viability on composite scaffolds compared to pure PCL scaffold demonstrates the more biocompatible nature of PC scaffolds. Cell adhesion efficiency indicates the possible application of the scaffolds as a transplant material.…”

Section: Cell Viability and Adhesionmentioning

confidence: 99%

“…14 Polymer/CNCs composites have been studied from the last several decades in tissue engineering applications. [15][16][17][18][19][20][21][22][23][24] Besides, it has been found that the external stimuli including the electrical eld have wide effects on cell proliferation in the presence of CNCs. 25 It was observed that CNCs have low electroactive materials, and this property can be tuned by using highly conductive materials such as graphene or carbon nanotube with CNCs.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Enhanced osteogenesis of mesenchymal stem cells on electrospun cellulose nanocrystals/poly(ε-caprolactone) nanofibers on graphene oxide substrates

2019

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Recent advances in electrospun polycaprolactone based scaffolds for wound healing and skin bioengineering applications

Cited by 152 publications

References 124 publications

A Multifunctional Pro‐Healing Zwitterionic Hydrogel for Simultaneous Optical Monitoring of pH and Glucose in Diabetic Wound Treatment

A Multifunctional Pro‐Healing Zwitterionic Hydrogel for Simultaneous Optical Monitoring of pH and Glucose in Diabetic Wound Treatment

Electrospun PCL and PLA hybrid nanofibrous scaffolds containing Nigella sativa herbal extract for effective wound healing

Enhanced osteogenesis of mesenchymal stem cells on electrospun cellulose nanocrystals/poly(ε-caprolactone) nanofibers on graphene oxide substrates

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