Recent advances in engineered polymeric materials for efficient photodynamic inactivation of bacterial pathogens

Sathishkumar, Gnanasekar; Kasi, Gopinath; He, Xiaodong; Zhang, Kai; Xu, Liqun; Kang, E. T.

doi:10.1016/j.bioactmat.2022.08.011

Cited by 72 publications

(55 citation statements)

References 156 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…175 Polymeric PLGA, polystyrene (PS) Covalent coupling, crosslinking, encapsulation ➢Functionalization improves drug elude efficacy, selectivity and biotoxicity of polymeric nanoparticles in cancer treatment. 176,177 ➢Enhance coupling ability for biomolecules, dyes and proteins. Metallic Ag, Pt, Au, Ni, Cu, Pd Covalent immobilization ➢Covalently immobilized nanoparticle helps to prevent leaching of nanocatalyst in immobilized reaction systems.…”

Section: Nanoparticle Immobilizationmentioning

confidence: 99%

Functionalized nanoparticles: Tailoring properties through surface energetics and coordination chemistry for advanced biomedical applications

et al. 2023

View full text Add to dashboard Cite

show abstract

Section: Nanoparticle Immobilizationmentioning

confidence: 99%

Functionalized nanoparticles: Tailoring properties through surface energetics and coordination chemistry for advanced biomedical applications

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Currently, the clinical treatments of IAI include the administration of antibiotics locally or systemically and mechanical procedures such as tissue debridement and replacement of the primary implant. , However, high-dose and long-term use of antibiotics leads to bacterial resistance, , which causes recurrent infections due to antibiotic-resistant strains and at least 700,000 deaths worldwide every year and threatens global public health . Antibiotic-free approaches are promising alternatives to prevent the abuse of antibiotics and bacterial resistance. − One prevalent strategy is the fabrication of bactericidal implant surfaces to combat bacterial adhesion and biofilm formation .…”

Section: Introductionmentioning

confidence: 99%

Biodegradable and Cytocompatible Hydrogel Coating with Antibacterial Activity for the Prevention of Implant-Associated Infection

Liu

Dong

Chen

et al. 2023

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Implant-associated infection (IAI) caused by pathogens colonizing on the implant surface is a serious issue in the trauma-orthopedic surgery, which often leads to implant failure. The complications of IAI bring a big threat to the clinical practice of implants, accompanied by significant economic cost and long hospitalization time. In this study, we propose an antibiotics-free strategy to address IAI-related challenges by using a biodegradable and cytocompatible hydrogel coating. To achieve this, a novel hydrogel system was developed to combine the synergistic effects of good cell affinity and antibacterial properties. The hydrogel material was prepared by modifying a photocross-linkable gelatinbased polymer (GelMA) with cationic quaternary ammonium salt (QAS) groups via a mild and simple synthesis procedure. By engineering the length of the hydrophobic carbon chain on the QAS group and the degree of functionalization, the resulting GelMA−octylQAS hydrogel exhibited an integration of good mechanical properties, biodegradability, excellent bactericidal activity against various types of bacteria, and high cytocompatibility with mammalian cells. When coated onto the implant via the in situ cross-linking procedure, our hydrogel demonstrated superior antimicrobial ability in the infective model of femoral fracture of rats. Our results suggest that the GelMA−octylQAS hydrogel might provide a promising platform for preventing and treating IAI.

show abstract

“…1,2 Antibiotics play an irreplaceable role in the clinical treatment to fight infections caused by bacteria. 3,4 However, abuse of antibiotics can lead to the formation of multidrug-resistant bacteria and biofilm formation. 5,6 Thus, it is urgent to develop non-antibiotic antibacterial technologies and agents.…”

Section: Introductionmentioning

confidence: 99%

In Situ Fabrication of Silver Peroxide Hybrid Ultrathin Co-Based Metal–Organic Frameworks for Enhanced Chemodynamic Antibacterial Therapy

Tan

Luo

et al. 2023

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Bacterial-induced infectious diseases have always caused an unavoidable problem and lead to an increasing threat to human health. Hence, there is an urgent need for effective antibacterial strategies to treat infectious diseases. Current methods are often ineffective and require large amounts of hydrogen peroxide (H2O2), with harmful effects on normal healthy tissue. Chemodynamic therapy (CDT) provides an ideal infection microenvironment (IME)-activated paradigm to tackle bacterial-related diseases. To take full advantage of the specificity of IME and enhanced CDT for wounds with bacterial infection, we have designed an intelligent antibacterial system that exploits nanocatalytic ZIF-67@Ag2O2 nanosheets. In this system, silver peroxide nanoparticles (Ag2O2 NPs) were grown on ultrathin zeolitic imidazolate framework-67 (ZIF-67) nanosheets by in situ oxidation, and then, ZIF-67@Ag2O2 nanosheets with the ability to self-generate H2O2 were triggered by the mildly acidic environment of IME. Lamellar ZIF-67 nanosheets were shown to rapidly degrade and release Co2+, allowing the conversion of less reactive H2O2 into the highly toxic reactive oxygen species hydroxyl radicals (•OH) for enhanced CDT antibacterial properties. In vivo results revealed that the ZIF-67@Ag2O2 nanosheet system exhibits excellent antibacterial performance against both Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. The proposed hybrid strategy demonstrates a promising therapeutic strategy to enable antibacterial agents with IME-responsive nanocatalytic activity to circumvent antibiotic resistance against bacterial infections.

show abstract

Recent advances in engineered polymeric materials for efficient photodynamic inactivation of bacterial pathogens

Cited by 72 publications

References 156 publications

Functionalized nanoparticles: Tailoring properties through surface energetics and coordination chemistry for advanced biomedical applications

Functionalized nanoparticles: Tailoring properties through surface energetics and coordination chemistry for advanced biomedical applications

Biodegradable and Cytocompatible Hydrogel Coating with Antibacterial Activity for the Prevention of Implant-Associated Infection

In Situ Fabrication of Silver Peroxide Hybrid Ultrathin Co-Based Metal–Organic Frameworks for Enhanced Chemodynamic Antibacterial Therapy

Contact Info

Product

Resources

About