Recent advances in extraction and analysis procedures of natural chlorogenic acids

Wianowska, Dorota; Gil, María Isabel Saz

doi:10.1007/s11101-018-9592-y

Cited by 101 publications

(93 citation statements)

References 120 publications

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“…Chlorogenic acid was isolated from different plants species such as Etlingera elatior leaves, coffee, and fruit [27] as well as medicinal plants [17]. The chlorogenic acid is known for strong its anti-oxidant, anti-cancer, anti-inflammatory, and antiviral properties, and modulates the anti-oxidant enzyme activities [28,29]. Protocatechuic acid, sinapic acid and p-hydroxybenzoic acid were relatively low but they are considered to be important anti-oxidant and anti-cancer compounds [30][31][32].…”

Section: Discussionmentioning

confidence: 99%

Mammillaria Species—Polyphenols Studies and Anti-Cancer, Anti-Oxidant, and Anti-Bacterial Activities

et al. 2019

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Discovering new natural resources of polyphenols is the aim of many recent studies in the field of natural product research. This study tentatively investigated the polyphenols profile of the stems of seven Mammillaria species (M. rhodantha, M. spinosissima, M. hahniana, M. crucigera, M. candida, M. albilanata, and M. muehlenpfordtii) using high performance liquid chromatography with DAD detector (HPLC-DAD) method. Furthermore, the anti-cancer, anti-oxidant, and anti-bacterial potentials of these extracts as well as major identified phenols were explored. The HPLC-DAD study confirmed the availability of six phenolic acids, including gentisic acid, chlorogenic acid, caffeic acid, protocatechuic acid, sinapic acid, and p-hydroxybenzoic acid. The dominant compounds were: gentisic acid in M. rhodantha and M. spinosissima; chlorogenic acid in M. muehlenpfordtii, M. crucigera, and M. rhodantha; and caffeic acid in M. rhodantha, M. crucigera, and M. spinosissima. Stems of Mammillaria sp. showed antiproliferative effects against HeLa, MCF-7, and Jurkat cells. In HeLa and MCF-7 cells, the best antiproliferative activities were found in the treatments with M. rhodantha, M. spinosissima, and M. muehlenpfordtii. The apoptotic assay of M. rhodantha, M. spinosissima, and M. muehlenpfordtii showed accumulation of necrotic cells in the early and late apoptotic phase. M. rhodantha, M. spinosissima, and M. muehlenpfordtii showed the highest anti-oxidant activities using 2,2-diphenyl-1-picrylhydrazyl (DPPH), β-carotene bleaching, and ferric reducing anti-oxidant power (FRAP) assays. M. rhodantha was the best source of antioxidants. Mammillaria sp. showed moderate anti-bacterial effects against bacteria and the highest effects were found using the extracts of M. rhodantha, M. spinosissima, M. crucigera and M. muehlenpfordtii against most bacteria. The anti-bacterial activities were attributed to other phenolic compounds (e.g., chlorogenic acid) than gentisic acid, which was not active against most bacteria. Mammillaria sp. could be considered to be an important natural source of phenolic acids with anti-cancer, anti-bacterial, and anti-oxidant activities.

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Section: Discussionmentioning

confidence: 99%

Mammillaria Species—Polyphenols Studies and Anti-Cancer, Anti-Oxidant, and Anti-Bacterial Activities

et al. 2019

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“…Four derivatives ( 10 , 18 , 21 , and 25 ) of chlorogenic acid were detected in VOP ( Table 3 , Figure 2 ). An interpretation of their MS 2 spectra using previously developed hierarchical keys enabled to assign these peaks to a particular positional derivative [ 38 , 39 , 40 ]. Furthermore, it was found that the fragment ion type and ion intensity were in a good correlation with the position of the caffeoyl group.…”

Section: Resultsmentioning

confidence: 99%

Valorization of European Cranberry Bush (Viburnum opulus L.) Berry Pomace Extracts Isolated with Pressurized Ethanol and Water by Assessing Their Phytochemical Composition, Antioxidant, and Antiproliferative Activities

Dienaitė

Pukalskienė

Pereira

et al. 2020

Foods

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Defatted by supercritical CO2, Viburnum opulus berry pomace (VOP) was subjected to consecutive extraction with pressurized ethanol (E) and water (W) and yielded 23% of VOP-E and 8% of VOP-W, respectively. The major phytochemical groups covering 42 identified and quantified constituents in VOP extracts were organic and phenolic acids, iridoids, quercetin and (epi)catechin derivatives, flavalignans, procyanidins, and anthocyanins. The on-line HPLC-DPPH•-scavenging assay revealed the presence of numerous antioxidants. VOP-E had a higher total phenolic content, was a stronger antioxidant (equivalent to 0.77, 0.42, and 0.17 g trolox/g in oxygen radical absorbance capacity (ORAC), ABTS, and DPPH assays, respectively), and recovered the major part of phenolics from the pomace; however, both extracts demonstrated similar antioxidant activity in the cellular assay. VOP-E inhibited HT29 cancer cells at non-cytotoxic concentrations. The results of this study revealed that VOP contains valuable phytochemicals possessing antioxidant and antiproliferative activities. Consequently, extracts from VOP substances may be of interest in developing functional ingredients for healthy foods, nutraceuticals, and cosmeceuticals.

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“…Chlorogenic acids, mono‐ and dicaffeoyl esters of quinic acid have attracted the attention of the scientists because of their broad spectrum of biological activities and their health effects, such as antispasmodic, hepatoprotective and choleretic activities, antioxidant, antiviral, antibacterial, anticancer and anti‐inflammatory properties, and reduction of the relative risk of diabetes type 2 and Alzheimer's disease . These secondary metabolites are widely distributed in Plant Kingdom and particularly in the species of Asteraceae family …”

Section: Introductionmentioning

confidence: 92%

Caffeoylquinic Acids, Cytotoxic, Antioxidant, Acetylcholinesterase and Tyrosinase Enzyme Inhibitory Activities of Six Inula Species from Bulgaria

Трендафилова

Ivanova

Rangelov

et al. 2020

Chemistry & Biodiversity

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Chlorogenic (5-CQA), 1,5-, 3,5-, 4,5-and 3,4-dicaffeoylquinic (DCQA) acids were identified and quantified in the methanol extracts of Inula oculus-christi L., I. bifrons L., I. aschersoniana JANKA var. aschersoniana, I. ensifolia L., I. conyza (GRIESS.) DC. and I. germanica L. by HPLC analysis. The amount of 5-CQA varied from 5.48 to 28.44 mg/g DE and the highest content was detected in I. ensifolia. 1,5-DCQA (4.05-55.25 mg/g DE) was the most abundant dicaffeoyl ester of quinic acid followed by 3,5-DCQA, 4,5-DCQA and 3,4-DCQA. The extract of I. ensifolia showed the highest total phenolic content (119.92 � 0.95 mg GAE/g DE) and exhibited the strongest DPPH radical scavenging activity (69.41 � 0.55 %). I. bifrons extract was found to be the most active sample against ABTS * + (TEAC 0.257 � 0.012 mg/mL) and the best tyrosinase inhibitor. The studied extracts demonstrated a low inhibitory effect towards acetylcholinesterase and possessed low cytotoxicity in concentration range from 10 to 300 μg/mL toward non-cancer (MDCK II) and cancer (A 549) cells. Figure 2. HPLC chromatograms of the studied extracts and standard mixture.[a] Results are presented as mean � SD from three replicates (n = 3). Means in the columns with the same letter are not significantly different from each other (p > 0.05) (t-test).

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Recent advances in extraction and analysis procedures of natural chlorogenic acids

Abstract: Chlorogenic acids (CQAs), the esters of caffeic and quinic acid, are biologically important phenolic compounds present in many plant species.

Cited by 101 publications

References 120 publications

Mammillaria Species—Polyphenols Studies and Anti-Cancer, Anti-Oxidant, and Anti-Bacterial Activities

Mammillaria Species—Polyphenols Studies and Anti-Cancer, Anti-Oxidant, and Anti-Bacterial Activities

Valorization of European Cranberry Bush (Viburnum opulus L.) Berry Pomace Extracts Isolated with Pressurized Ethanol and Water by Assessing Their Phytochemical Composition, Antioxidant, and Antiproliferative Activities

Caffeoylquinic Acids, Cytotoxic, Antioxidant, Acetylcholinesterase and Tyrosinase Enzyme Inhibitory Activities of Six Inula Species from Bulgaria

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