Recent advances in fluorescence imaging-guided photothermal therapy and photodynamic therapy for cancer: From near-infrared-I to near-infrared-II

Luo, Hangqi; Gao, Shuai

doi:10.1016/j.jconrel.2023.08.056

Cited by 38 publications

(6 citation statements)

References 222 publications

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“…Notably, J-aggregate PDDO NPs not only have higher ε (2.37 × 10 5 M –1 cm –1 ) and QY (14.0%) but also maintain greater PCE (51.1%). This is one of the known NIR nanoprobes with the highest brightness (ε × QY = 3.32 × 10 4 M –1 cm –1 ) and photothermal performance (ε × PCE = 1.21 × 10 5 M –1 cm –1 ) . Finally, in vivo tumor experiments have convincingly demonstrated the exceptional capability of PDDO NPs for NIR FLI-guided PTT.…”

Section: Introductionmentioning

confidence: 71%

Pyrrolopyrrole Cyanine J-Aggregate Nanoparticles with High Near-Infrared Fluorescence Brightness and Photothermal Performance for Efficient Phototheranostics

Xu,

Meng,

Zhao

et al. 2024

ACS Appl. Mater. Interfaces

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Advanced photosensitizers for high-performance fluorescence imaging-guided photothermal therapy demand excellent near-infrared (NIR) brightness [molar absorption coefficient (ε) × quantum yield (QY)] and exceptional photothermal performance [ε × photothermal conversion efficiency (PCE)]. However, integrating high brightness and potent photothermal performance within a single molecule faces a formidable challenge. This article proposes a method to address this issue by preparing J-aggregate nanoparticles (NPs) using molecules with high ε. J-aggregates effectively improve QY and induce molecular emission redshift, while high ε molecules play a crucial role in improving the brightness and photothermal performance. By optimizing the molecular structure based on the pyrrolopyrrole cyanine (PPCy), precise control over the QY and PCE of PPCy J-aggregates is achieved. Ultimately, PDDO NPs exhibiting superior brightness (ε × QY = 3.32 × 10 4 M −1 cm −1 ) and photothermal performance (ε × PCE = 1.21 × 10 5 M −1 cm −1 ) are identified as high-performance photosensitizers. Notably, each parameter represents one of the highest levels among the reported fluorescence or photothermal probes to date. The in vivo studies demonstrate that PDDO NPs possess exceptional NIR imaging capabilities and remarkable photothermal tumor inhibition rates. This study provides innovative insights into the development of high-performance multifunctional photosensitizers.

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Section: Introductionmentioning

confidence: 71%

Pyrrolopyrrole Cyanine J-Aggregate Nanoparticles with High Near-Infrared Fluorescence Brightness and Photothermal Performance for Efficient Phototheranostics

Xu,

Meng,

Zhao

et al. 2024

ACS Appl. Mater. Interfaces

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“…The continuous development of NanoPSs has endowed certain types with not only photosensitivity but also sonosensitivity and photothermal properties [39,40]. These characteristics enable PDT to be combined with sonodynamic therapy (SDT) or photothermal therapy (PTT), providing sufficient flexibility to integrate with other treatment modalities to achieve synergistic effects [41,42]. For example, research by Liao et al has found that Chlorin e6 exhibits efficient photosensitivity and sonosensitivity, playing a crucial role in sonodynamic therapy combined with PDT [43].…”

Section: Versatile Therapeutic Strategies Utilizing Nanopssmentioning

confidence: 99%

Therapeutic Applications of Nanomedicine: Recent Developments and Future Perspectives

Rehan,

Zhang,

Fang

et al. 2024

Molecules

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The concept of nanomedicine has evolved significantly in recent decades, leveraging the unique phenomenon known as the enhanced permeability and retention (EPR) effect. This has facilitated major advancements in targeted drug delivery, imaging, and individualized therapy through the integration of nanotechnology principles into medicine. Numerous nanomedicines have been developed and applied for disease treatment, with a particular focus on cancer therapy. Recently, nanomedicine has been utilized in various advanced fields, including diagnosis, vaccines, immunotherapy, gene delivery, and tissue engineering. Multifunctional nanomedicines facilitate concurrent medication delivery, therapeutic monitoring, and imaging, allowing for immediate responses and personalized treatment plans. This review concerns the major advancement of nanomaterials and their potential applications in the biological and medical fields. Along with this, we also mention the various clinical translations of nanomedicine and the major challenges that nanomedicine is currently facing to overcome the clinical translation barrier.

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“…The potential clinical application of photodynamic therapy in head and neck diseases is a promising avenue for improving treatment outcomes while minimizing side effects [192]. With ongoing advancements in technology and a growing body of evidence supporting its efficacy, PDT is poised to play a significant role in the multidisciplinary approach to managing various conditions in the intricate anatomy of the head and neck [193]. Photodynamic therapy significant advances have been made in refining PDT protocols, enhancing its efficacy, and expanding its scope, but the approach is not without its limitations.…”

Section: Clinical Use Advances and Limitations In The Use Of Photodyn...mentioning

confidence: 99%

Photodynamic Therapy for Eye, Ear, Laryngeal Area, and Nasal and Oral Cavity Diseases: A Review

Domka,

Bartusik-Aebisher,

Mytych

et al. 2024

Cancers

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Photodynamic therapy (PDT) has emerged as a promising modality for the treatment of various diseases. This non-invasive approach utilizes photosensitizing agents and light to selectively target and destroy abnormal cells, providing a valuable alternative to traditional treatments. Research studies have explored the application of PDT in different areas of the head. Research is focusing on a growing number of new developments and treatments for cancer. One of these methods is PDT. Photodynamic therapy is now a revolutionary, progressive method of cancer therapy. A very important feature of PDT is that cells cannot become immune to singlet oxygen. With this therapy, patients can avoid lengthy and costly surgeries. PDT therapy is referred to as a safe and highly selective therapy. These studies collectively highlight the potential of PDT as a valuable therapeutic option in treating the head area. As research in this field progresses, PDT may become increasingly integrated into the clinical management of these conditions, offering a balance between effectiveness and minimal invasiveness.

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Recent advances in fluorescence imaging-guided photothermal therapy and photodynamic therapy for cancer: From near-infrared-I to near-infrared-II

Cited by 38 publications

References 222 publications

Pyrrolopyrrole Cyanine J-Aggregate Nanoparticles with High Near-Infrared Fluorescence Brightness and Photothermal Performance for Efficient Phototheranostics

Pyrrolopyrrole Cyanine J-Aggregate Nanoparticles with High Near-Infrared Fluorescence Brightness and Photothermal Performance for Efficient Phototheranostics

Therapeutic Applications of Nanomedicine: Recent Developments and Future Perspectives

Photodynamic Therapy for Eye, Ear, Laryngeal Area, and Nasal and Oral Cavity Diseases: A Review

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