Recent Advances in Green Synthesis of Functionalized Quinolines of Medicinal Impact (2018‐Present)

Abstract

The synthetic chemists are awakening to make substantial development in finding safer drugs against the rising communicable and non‐communicable type of diseases. By replacing traditional methods to more sustainable and greener approaches, multicomponent reactions are the rapid and efficient tool for the synthesis of organic molecules of structural diversity and complexity. Heterocyclic chemistry transforms small set of precursors into series of molecules by multicomponent domino reactions. This review covers recent trends of last five years (2018–2022) in construction of potentially drug‐like quinoline derivatives. The methods discussed here are preferable over conventional approaches being inexpensive, consuming lesser reaction time, atom economical, saving energy and manpower while avoiding toxic reagents/materials, chemical wastes and are environmental/occupational benign. The contributions covered here involve metallic, metal free strategies and other catalytic pathways including nanoparticles, ionic liquids and photocatalysis which are operationally safe and reliable.

Synthesis and Antiproliferative Activity of Steroidal Diaryl Ethers

“…The development of highly efficient, environmentally friendly catalytic synthetic methods is one of the major goals of modern organic chemistry [ 1 ]. Carbon–heteroatom (C–X) bond formation is often a key challenge for organic chemists [ 2 , 3 , 4 , 5 , 6 , 7 , 8 ]. It is still desirable to develop mild but effective methods, which allow the construction of the C–X bond with high functional group tolerance.…”

Accelerated sonosynthesis of chromeno[4,3‐b]quinoline derivatives via marine‐bioinspired tin oxide nanocatalyst

“…Due to their diverse biological activities, chromeno [4,3-b]quinoline derivatives have the potential for further development as lead compounds for drug discovery in numerous therapeutic areas. 30,31 In this study, we explore new synthetic routes and modifications to improve the potency and selectivity of chromeno [4,3-b] quinoline derivatives using marine diatom-mediated SnO 2 NPs, as part of our ongoing efforts to apply green NPs technology in organic synthesis. 32 The entire synthetic reaction was performed in desirable water solvent under ultrasound conditions.…”