Recent advances in injectable hydrogel therapies for periodontitis

Ran, Shidian; Xue, Linyu; Wei, Xiaorui; Huang, Jindie; Yan, Xingrui; He, Tong-Chuan; Tang, Zhurong; Zhang, Hongmei; Gu, Mengqin

doi:10.1039/d3tb03070a

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A nucleoside-based supramolecular hydrogel integrating localized self-delivery and immunomodulation for periodontitis treatment

Shuai,

Yin,

Yao

et al. 2025

Biomaterials

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A nucleoside-based supramolecular hydrogel integrating localized self-delivery and immunomodulation for periodontitis treatment

Shuai,

Yin,

Yao

et al. 2025

Biomaterials

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Fibroblasts derived C3 promotes the progression of experimental periodontitis through macrophage M1 polarization and osteoclast differentiation

Sun,

ren,

Zheng

et al. 2024

Preprint

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Complement C3 plays a critical role in periodontitis. However, its source, role and underlying mechanisms remain unclear. In our study, by analyzing single-cell sequencing data from mouse model of periodontitis, we identified that C3 is primarily derived from periodontal fibroblasts. Subsequently, we demonstrated that C3a has a detrimental effect in ligature-induced periodontitis. C3ar-/- mice exhibited significantly less destruction of periodontal support tissues compared to wild-type mice, characterized by mild gingival tissue damage and reduced alveolar bone loss. This reduction was associated with decreased production of pro-inflammatory mediators and reduced osteoclast infiltration in the periodontal tissues. Mechanistic studies suggested that C3a could promote macrophage polarization and osteoclast differentiation. Finally, by analyzing single-cell sequencing data from the periodontal tissues of patients with periodontitis, we found that the results observed in mice were consistent with human data. Therefore, our findings clearly demonstrate the destructive role of fibroblast-derived C3 in ligature-induced periodontitis, driven by macrophage M1 polarization and osteoclast differentiation. These data strongly support the feasibility of C3a-targeted interventions for the treatment of human periodontitis.

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Recent advances in injectable hydrogel therapies for periodontitis

Abstract: Periodontitis is an immune-inflammatory disease caused by dental plaque, which deteriorates the periodontal ligament, causes alveolar bone loss, and may lead to tooth loss. To treat periodontitis, antibacterial and anti-inflammation...

Cited by 2 publications

References 141 publications

A nucleoside-based supramolecular hydrogel integrating localized self-delivery and immunomodulation for periodontitis treatment

A nucleoside-based supramolecular hydrogel integrating localized self-delivery and immunomodulation for periodontitis treatment

Fibroblasts derived C3 promotes the progression of experimental periodontitis through macrophage M1 polarization and osteoclast differentiation

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