Recent Advances in Insulin Therapy

Wilson, Leah M.; Castle, Jessica R.

doi:10.1089/dia.2020.0065

Cited by 33 publications

(18 citation statements)

References 73 publications

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“…Moreover, the lower increase in weight documented with Glar-300 is an additional benefit. In this sense, it can be argued that in cases where an individual under treatment with Glar-100 has an unacceptably high frequency of hypoglycemia or where a therapeutic objective is weight reduction (or at least no weight gain), it is reasonable to consider a switch to insulins such as Deg-100 or Glar-300 (with greater evidence of benefit for body weight than Glar-100) [ 70 , 71 ].…”

Section: Discussionmentioning

confidence: 99%

Current State and Principles of Basal Insulin Therapy in Type 2 Diabetes

Vargas‐Uricoechea

2022

J Clin Med Res

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Treatment with basal insulins is a fundamental part of management in many patients with type 2 diabetes mellitus. Multiple management schemes may be indicated in these individuals, for example, the use of oral antihyperglycemic agents with basal insulins (basal-supported oral therapy) or the combinations of basal insulins with glucagon-like peptide-1 receptor agonists; each of these strategies makes it easier to achieve glycemic control goals. A basic knowledge of the physiology, pharmacodynamic and pharmacokinetic aspects of the different basal insulins is essential to achieve treatment goals and compliance. This review addresses the principles of management with basal insulins.

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Section: Discussionmentioning

confidence: 99%

Current State and Principles of Basal Insulin Therapy in Type 2 Diabetes

Vargas‐Uricoechea

2022

J Clin Med Res

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“…For T1D and advanced T2D, insulin is the most used drug to effectively control blood glucose levels (BGLs) [113] , [114] , [115] . To date, there are several insulin formulations available on the market [ 116 , 117 ]. Usually, these formulations are administrated by subcutaneous injection mediated by hypodermic needle or pump [115] .…”

Section: The Biomedical Application Of Mn@srsmentioning

confidence: 99%

Polymeric microneedle‐mediated sustained release systems: Design strategies and promising applications for drug delivery

Yang

Chen

et al. 2022

Asian Journal of Pharmaceutical Sciences

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“…The inhaled insulin delivery may cause safety issues in lungs. We refer interested readers for more detailed understanding about both these two insulin methods to the latest findings in recent studies [75][76][77][78][79][80]. Pharmacokinetics deals with the absorption and distribution process of the insulin in a human body.…”

Section: Subcutaneous Versus Inhaled Insulinmentioning

confidence: 99%

Artificial Pancreas Control Strategies Used for Type 1 Diabetes Control and Treatment: A Comprehensive Analysis

Mehmood

Ahmad

Arif

et al. 2020

ASI

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This paper presents a comprehensive survey about the fundamental components of the artificial pancreas (AP) system including insulin administration and delivery, glucose measurement (GM), and control strategies/algorithms used for type 1 diabetes mellitus (T1DM) treatment and control. Our main focus is on the T1DM that emerges due to pancreas’s failure to produce sufficient insulin due to the loss of beta cells (β-cells). We discuss various insulin administration and delivery methods including physiological methods, open-loop, and closed-loop schemes. Furthermore, we report several factors such as hyperglycemia, hypoglycemia, and many other physical factors that need to be considered while infusing insulin in human body via AP systems. We discuss three prominent control algorithms including proportional-integral- derivative (PID), fuzzy logic, and model predictive, which have been clinically evaluated and have all shown promising results. In addition, linear and non-linear insulin infusion control schemes have been formally discussed. To the best of our knowledge, this is the first work which systematically covers recent developments in the AP components with a solid foundation for future studies in the T1DM field.

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Recent Advances in Insulin Therapy

Cited by 33 publications

References 73 publications

Current State and Principles of Basal Insulin Therapy in Type 2 Diabetes

Current State and Principles of Basal Insulin Therapy in Type 2 Diabetes

Polymeric microneedle‐mediated sustained release systems: Design strategies and promising applications for drug delivery

Artificial Pancreas Control Strategies Used for Type 1 Diabetes Control and Treatment: A Comprehensive Analysis

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