Recent Advances in Magnetofection and Its Potential to Deliver siRNAs In Vitro

Mykhaylyk, Olga; Zelphati, Olivier; Hammerschmid, Edelburga; Anton, Martina; Rosenecker, Joseph; Plank, Christian

doi:10.1007/978-1-60327-547-7_6

Cited by 59 publications

(68 citation statements)

References 37 publications

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“…Their "programming" takes place on a biological or chemical level rather than a logical. Details about this can be found in [1] and [2]. Another medical application is blood purification.…”

Section: A Motivationmentioning

confidence: 99%

Self-organizing Particle Systems

Drees

Hüllmann

Koutsopoulos

et al. 2012

2012 IEEE 26th International Parallel and Distributed Processing Symposium

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Abstract-Nanoparticles are getting more and more in the focus of the scientific community since the potential for the development of very small particles interacting with each other and completing medical and other tasks is getting bigger year by year. In this work we introduce a distributed local algorithm for arranging a set of nanoparticles on the discrete plane into specific geometric shapes, for instance a rectangle. The concept of a particle we use can be seen as a simple mobile robot with the following restrictions: it can only view the state of robots it is physically connected to, is anonymous, has only a constant size memory, can only move by using other particles as an anchor point on which it pulls itself alongside, and it operates in Look-ComputeMove cycles. The main result of this work is the presentation of a random distributed local algorithm which transforms any given connected set of particles into a particular geometric shape. As an example we provide a version of this algorithm for forming a rectangle with an arbitrary predefined aspect ratio. To the best of our knowledge this is the first work that considers arrangement problems for these types of robots.

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“…Their "programming" takes place on a biological or chemical level rather than a logical. Details about this can be found in [1] and [2]. Another medical application is blood purification.…”

Section: A Motivationmentioning

confidence: 99%

Self-organizing Particle Systems

Drees

Hüllmann

Koutsopoulos

et al. 2012

2012 IEEE 26th International Parallel and Distributed Processing Symposium

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“…These complexes readily associate with negatively charged DNA since the magnetic particles are positively charged due to the polyethylenimine. Whether viral or nonviral vectors, MF has been shown to enhance the efficiency of the vectors up to several thousand times 45,46 . Also combination of magnetic targeting with controlled release seems to be a very promising field [47][48][49][50][51] .…”

Section: Magnetic Drug Delivery and Targeting: Principles And Applicamentioning

confidence: 99%

Magnetic Drug Delivery and Targeting: Principles and Applications

Babincová¹,

Babinec²

2009

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background: Nanomaterials are at the leading edge of the rapidly developing field of nanotechnology. Magnetic nanoparticles for cancer therapy and diagnosis have been developed on the basis of their unique physico-chemical properties not present in other materials. Their versatility is widely exploited in such diverse techniques as cell and macromolecule separation and purification, immunoassays, targeted drug delivery, controlled material release, electromagnetic hyperthermia, gene therapy, or magnetic resonance imaging. In this review we concentrate on the physical principles of magnetic drug targeting and biomedical applications of this technique. Methods and results:We examined several databases, PubMed, ISI Web of Knowledge, and Scopus, for the period 1985-2009, with specific attention to studies that used targeting of magnetic nanoparticles especially in the therapy and diagnostics of tumors. We have also presented several of our own results on theoretical simulations of magnetic particle motion in external magnetic field.Conclusions: We found growing number of published papers in this field of nanomedicine, showing the almost unlimited potential of magnetic nanoparticles in the field of experimental and clinical oncology.

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“…Especially in the last decade, many novel applications of MNPs have been proposed and investigated for biological or medicinal approaches remarkably in the fields of Magnetofection TM (e.g. Mykhaylyk et al 2009), magnetic separation procedures (e.g. Clement et al 2006), magnetic resonance imaging (MRI) as contrast agents (e.g.…”

Section: Introductionmentioning

confidence: 99%

Quantification of the aggregation of magnetic nanoparticles with different polymeric coatings in cell culture medium

Eberbeck

Kettering

Bergemann³

et al. 2010

J. Phys. D: Appl. Phys.

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To cite this version:DAbstract. The knowledge of the physico-chemical characteristics of magnetic nanoparticles (MNPs) is essential to enhance the efficacy of MNP-based therapeutic treatments (e.g. magnetic heating, magnetic drug targeting). According to the literature, the MNP uptake by cells may depend on the coating of MNPs, the surrounding medium as well as on the aggregation behaviour of the MNPs. Therefore, in this study, the aggregation behaviour of MNPs in various media was investigated. MNPs with different coatings were suspended in cell culture medium (CCM) containing fetal calf serum (FCS), and the distribution of the hydrodynamic sizes was measured by magnetorelaxometry (MRX). FCS as well as BSA-buffer (phosphate buffered saline with 0.1% bovine serum albumin) may induce MNP aggregation. Its strength depends crucially on the type of coating. The degree of aggregation in CCM depends on its FCS content showing a clear, local maximum at FCS concentrations, where the IgGconcentration (part of FCS) is of the order of the MNP number concentration. Thus, we attribute the observed aggregation behaviour to the mechanism of agglutination of MNPs by serum compartments as for example IgG. No aggregation was induced for MNPs coated with dextran, polyarabic acid, or sodium phosphate, respectively, which were colloidally stable in CCM.

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Recent Advances in Magnetofection and Its Potential to Deliver siRNAs In Vitro

Cited by 59 publications

References 37 publications

Self-organizing Particle Systems

Self-organizing Particle Systems

Magnetic Drug Delivery and Targeting: Principles and Applications

Quantification of the aggregation of magnetic nanoparticles with different polymeric coatings in cell culture medium

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