Recent advances in microfluidic technology for manipulation and analysis of biological cells (2007–2017)

Alam, Kowsar; Koomson, Emmanuel; Zou, Heng; Yi, Changqing; Li, Cheuk‐Wing; Xu, Tao; Yang, Mengsu

doi:10.1016/j.aca.2018.06.054

Cited by 81 publications

(43 citation statements)

References 327 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent years, certain applications have emerged, from the detection of infectious diseases to diagnostics for international public health [41]. Several on-chip clinical assessments have also appeared include cell analysis, cytometry, blood analysis, nucleic acids amplification, genetic mapping, enzymatic assays, peptide analysis, protein separation, toxicity analysis, and bioassays [42]. In the area of drug research, the LoC devices have gradually became significant with the prominence on cell targeting, clinical trials, drug synthesis, pharmaceutical formulations, and product management process [43].…”

Section: Advantages Of Microfluidic Lab-on-a-chip Technologymentioning

confidence: 99%

mHealth-Based Microfluidic Lab-on-a-Chip for International Health Security

Baig¹

2021

Contemporary Developments and Perspectives in International Health Security - Volume 1

View full text Add to dashboard Cite

The increasing threats of emerging and reemerging infectious disease outbreaks demand research and development (R&D) of effective and fit-for-all-purpose tools and technologies for international public health security. Recent advances in biomedical engineering, mostly related to the convergence of communication and network technology in health, i.e., mobile health with microfluidic Lab-ona-Chip technology can improve the international public health crises and employ in international public health security. Lab-on-a-Chip technology is now commonly found in most research centers, hospitals, and clinics where health care infrastructure is weak, and access to quality and timely medical care is challenging. Microfluidic devices-also known as Lab-on-a-Chip (LoC)-are an alternative for accessible, cost-effective, and early detection medical trials. The mHealth-based microfluidic LoC technology has been under rapid development, and they are becoming influential tools in a wide range of biomedical research and international public health applications. The perspective in this chapter demonstrates a potentially transformative opportunity for the deployment of mHealth with LoC with the fabrication protocols and their potential for strengthening and improving the international public health security. This attempt is not conclusive and exhaustive, and it is anticipated that such a discussion will enable the exchange of ideas between biomedical engineering, microfluidic LoC technology professionals, international public health, and health security experts.

show abstract

Section: Advantages Of Microfluidic Lab-on-a-chip Technologymentioning

confidence: 99%

mHealth-Based Microfluidic Lab-on-a-Chip for International Health Security

Baig¹

2021

Contemporary Developments and Perspectives in International Health Security - Volume 1

View full text Add to dashboard Cite

show abstract

“…Microfluidic technology can be applied in cell biology, disease research, and drug development [71][72][73]. Microfluidic technology can provide us with a lot of mechanical information (shear stress, constraint, base stiffness) [74].…”

Section: Microfluidic Technologymentioning

confidence: 99%

Recent Advances on the Model, Measurement Technique, and Application of Single Cell Mechanics

Huang

Dai

Shen

et al. 2020

IJMS

View full text Add to dashboard Cite

Since the cell was discovered by humans, it has been an important research subject for researchers. The mechanical response of cells to external stimuli and the biomechanical response inside cells are of great significance for maintaining the life activities of cells. These biomechanical behaviors have wide applications in the fields of disease research and micromanipulation. In order to study the mechanical behavior of single cells, various cell mechanics models have been proposed. In addition, the measurement technologies of single cells have been greatly developed. These models, combined with experimental techniques, can effectively explain the biomechanical behavior and reaction mechanism of cells. In this review, we first introduce the basic concept and biomechanical background of cells, then summarize the research progress of internal force models and experimental techniques in the field of cell mechanics and discuss the latest mechanical models and experimental methods. We summarize the application directions of cell mechanics and put forward the future perspectives of a cell mechanics model.

show abstract

“…In the microfluidic chips, microchannels networks are formed. By regulating the flow of liquid in microchannel, biological, and chemical analysis are performed in the chips [20,21]. In recent years, many researchers use microfluidic chip to construct the BBB models and achieved good experimental results.…”

Section: Introductionmentioning

confidence: 99%

Recent Progress in Microfluidic Models of the Blood-Brain Barrier

Jiang

Zheng

et al. 2019

Micromachines

View full text Add to dashboard Cite

The blood-brain barrier (BBB) is a critical physical and chemical barrier that maintains brain homeostasis. Researchers in academia and industry are highly motivated to develop experimental models that can accurately mimic the physiological characteristics of the BBB. Microfluidic systems, which manipulate fluids at the micrometer scale, are ideal tools for simulating the BBB microenvironment. In this review, we summarized the progress in the design and evaluation of microfluidic in vitro BBB models, including advances in chip materials, porous membranes, the use of endothelial cells, the importance of shear stress, the detection specific markers to monitor tight junction formation and integrity, measurements of TEER and permeability. We also pointed out several shortcomings of the current microfluidic models. The purpose of this paper is to let the readers understand the characteristics of different types of model design, and select appropriate design parameters according to the research needs, so as to obtain the best experimental results. We believe that the microfluidics BBB models will play an important role in neuroscience and pharmaceutical research.

show abstract

Recent advances in microfluidic technology for manipulation and analysis of biological cells (2007–2017)

Cited by 81 publications

References 327 publications

mHealth-Based Microfluidic Lab-on-a-Chip for International Health Security

mHealth-Based Microfluidic Lab-on-a-Chip for International Health Security

Recent Advances on the Model, Measurement Technique, and Application of Single Cell Mechanics

Recent Progress in Microfluidic Models of the Blood-Brain Barrier

Contact Info

Product

Resources

About