2024
DOI: 10.1055/s-0044-1788072
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Recent Advances in Mitochondrial Pyruvate Carrier Inhibitors

Yilei Huang,
Han Zhang,
Xinyan Peng
et al.

Abstract: The mitochondrial pyruvate carrier (MPC) exists in the mitochondria inner membrane which transports pyruvate to the mitochondrial matrix. Evidence shows that MPC is the breakthrough point to study the regulation of basic energy metabolism, the dysfunction of which may lead to metabolic disturbance. Due to its important metabolic function, MPC has been considered a potential therapeutic target for diabetes, alopecia, cancers, neurodegenerative diseases, and liver metabolic diseases. However, MPC' protein crysta… Show more

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