Recent Advances in Multicatalyst Promoted Asymmetric Tandem Reactions

Abstract

Dedicated to the 150th anniversary of Japan-UK diplomatic relations FOCUS REVIEWSAbstract: Multicatalyst promoted asymmetric tandem reactions have emerged as a powerful strategy to improve the synthetic efficiency. It enables the synthesis of complex molecules with high selectivity from simple starting materials in an almost biomimetic-like way. The use of multiple catalyst systems can enlarge the substrate and reaction scope for the reaction design, improve the reactivity, and benefit the control of selectivity. In this FocusReview, the current achievement of this promising field is discussed, including the advantages and difficulties of this research, and the strategies applied to address these problems.

Sequence-Regulated Polymers via Living Radical Polymerization: From Design to Properties and Functions

“…Tandem catalysis is an intriguing one-pot synthetic approach much more efficient and convenient than multi-step synthesis, in which different two or more reactions simultaneously and/or sequentially undergo in a single vessel to directly give products without any purification and/or isolation of intermediates (17)(18)(19)(20)(21)(22)(23). The key for efficient tandem catalysis is the compatibility of respective active intermediates and chemical reagents (catalysts, substrates) in different reactions; if one component deactivates another, tandem catalysis never proceeds.…”

2.07 The Aldol Reaction: Organocatalysis Approach

“…These combinations allow for the regio-and stereoselective synthesis of complex molecule from readily available, simple starting materials. [164][165][166][167] A one-pot Rh complex-catalyzed hydroformylation, following (S)-proline-catalyzed enantioselective cross-aldol reaction sequence, is one example ( Table 5). 168 Simple alkenes 310 are transformed in situ to aliphatic aldehydes 311, giving aldol products 312 in good yields with excellent stereoselectivities in a one-pot operation.…”

Progress of Cooperative Catalysis in Organic Synthesis

“…因此, 设计和开发新的催化体系一直都是有机 合成领域的一大研究方向和热点. 其中, 两种或者两种 以上催化剂参与的共催化体系, 因其可实现原本不能或 者难以发生的反应, 具有高效、经济、绿色、操作简单 等优点而引起了化学家的极大兴趣, 在新药设计与合 成、天然产物合成和组合化学中都有广泛的应用 [1,2] . 同样, 利用过渡金属催化的炔的胺化反应, 刘学伟 研究组 [6] 报道了以 Cu(OAc) 2 [7] .…”

“…同样, 利用过渡金属催化的炔的胺化反应, 刘学伟 研究组 [6] 报道了以 Cu(OAc) 2 [7] . Nakao 研究组 [8] 曾报道了利用金属 Ni 和 Zn(Me) 2 [12,13] 、Ir-Ru 共催化 [14] 、Au-Ag 共催化 [15] 、 Co-Ti 共催化 [16] 、Ni-Al 共催化、Ru-Pd 共催化 [17] 等体系 在有机合成中都有很好的应用.…”