Recent Advances in Nanodentistry

Izadi, Zhila; Derakhshankhah, Hossein; Alaei, Loghman; Karkazis, Emelia; Jafari, Samira; Tayebi, Lobat

doi:10.1007/978-3-030-21583-5_12

Cited by 3 publications

(3 citation statements)

References 98 publications

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“…In the previous sections, it was also shown that different drugs and drug concentrations, respectively, are particularly beneficial, depending on the stage of tissue regeneration. Thus, release materials possessing multiple release mechanisms or materials that release the active ingredient in response to a certain stimulus are the focus of recent research [456][457][458][459][460][461].…”

Section: Drug Release Concepts Mechanisms and Applications In Stem Cell-based Osteogenesis And Angiogenesismentioning

confidence: 99%

Sinking Our Teeth in Getting Dental Stem Cells to Clinics for Bone Regeneration

Shoushrah

Transfeld

Tonk

et al. 2021

IJMS

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Dental stem cells have been isolated from the medical waste of various dental tissues. They have been characterized by numerous markers, which are evaluated herein and differentiated into multiple cell types. They can also be used to generate cell lines and iPSCs for long-term in vitro research. Methods for utilizing these stem cells including cellular systems such as organoids or cell sheets, cell-free systems such as exosomes, and scaffold-based approaches with and without drug release concepts are reported in this review and presented with new pictures for clarification. These in vitro applications can be deployed in disease modeling and subsequent pharmaceutical research and also pave the way for tissue regeneration. The main focus herein is on the potential of dental stem cells for hard tissue regeneration, especially bone, by evaluating their potential for osteogenesis and angiogenesis, and the regulation of these two processes by growth factors and environmental stimulators. Current in vitro and in vivo publications show numerous benefits of using dental stem cells for research purposes and hard tissue regeneration. However, only a few clinical trials currently exist. The goal of this review is to pinpoint this imbalance and encourage scientists to pick up this research and proceed one step further to translation.

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Section: Drug Release Concepts Mechanisms and Applications In Stem Cell-based Osteogenesis And Angiogenesismentioning

confidence: 99%

Sinking Our Teeth in Getting Dental Stem Cells to Clinics for Bone Regeneration

Shoushrah

Transfeld

Tonk

et al. 2021

IJMS

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“…To evaluate any possible postoperative sensitivity, the patients were verbally questioned regarding the following aspects: sensitivity to cold and/or hot, spontaneous pain either prolonged or not and pain during mastication and sensitivity from other stimuli 12 .…”

Section: Clinical Evaluationmentioning

confidence: 99%

Effect of Hydro- abrasion versus Conventional Cavity Preparation on the Clinical Performance of Composite Resin Restoration

kashkosh

Genaid

2021

Egyptian Dental Journal

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Aim: To evaluate the effect of hydro abrasion versus the conventional drill method of cavity preparation on the clinical performance of composite restoration over one year follow up period. Materials and methods:Twenty patients with occlusal carious lesions were selected and examined with DIAGNO cam and ICDAS visual criteria to select teeth having ICDAS Code 3 or 4. Forty lesions were randomly divided into two groups (n=20) according to the method of caries removal. Cavities were prepared by the conventional drill method in group I and by hydro-abrasion in group II. Cavities of both groups were restored by self-etch adhesive (Adper Easy Bond) and nano-filled composite (Filtek Z350XT). All restorations were evaluated after 24 hours, after 9 and 12 months according to (USPHS) criteria for retention, marginal adaptation, postoperative sensitivity, marginal discoloration, and secondary caries.Results: Mild, moderate -severe and very severe pain was recorded in group I While in group II, only mild pain was recorded in (40%) of cases. The statistical analysis of the collected data related to the tested USPHS criteria revealed 100% Alpha scoring regarding retention, marginal adaptation and secondary caries in both groups throughout the study period. The gap width measured under SEM was found increased sig. by time in both groups. Marginal discoloration was observed in the two groups after nine and 12 months. Post-operative hypersensitivity was found only in group I in 100% of cases at the base line and was disappeared during the next follow up period. Conclusion:Hydro-abrasion could be recommended as a preferred method of cavity preparation in shallow to mild carious lesions compared to the conventional cavity preparation method.

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“…Future efforts should be directed toward the development of tailored drug loading and/or encapsulation materials to be used for the controlled release of bioactive substances during tooth formation [157,173]. As shown in Figure 2 and Table 1, there are various signaling molecules and corresponding activators and suppressor molecules involved in the formation of enamel, dentin, and cementum.…”

Section: Drug Release Systems Useful In Tissue Engineering-to Be Adapted To Tooth Engineeringmentioning

confidence: 99%

Tooth Formation: Are the Hardest Tissues of Human Body Hard to Regenerate?

Baranova

Büchner

Götz

et al. 2020

IJMS

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With increasing life expectancy, demands for dental tissue and whole-tooth regeneration are becoming more significant. Despite great progress in medicine, including regenerative therapies, the complex structure of dental tissues introduces several challenges to the field of regenerative dentistry. Interdisciplinary efforts from cellular biologists, material scientists, and clinical odontologists are being made to establish strategies and find the solutions for dental tissue regeneration and/or whole-tooth regeneration. In recent years, many significant discoveries were done regarding signaling pathways and factors shaping calcified tissue genesis, including those of tooth. Novel biocompatible scaffolds and polymer-based drug release systems are under development and may soon result in clinically applicable biomaterials with the potential to modulate signaling cascades involved in dental tissue genesis and regeneration. Approaches for whole-tooth regeneration utilizing adult stem cells, induced pluripotent stem cells, or tooth germ cells transplantation are emerging as promising alternatives to overcome existing in vitro tissue generation hurdles. In this interdisciplinary review, most recent advances in cellular signaling guiding dental tissue genesis, novel functionalized scaffolds and drug release material, various odontogenic cell sources, and methods for tooth regeneration are discussed thus providing a multi-faceted, up-to-date, and illustrative overview on the tooth regeneration matter, alongside hints for future directions in the challenging field of regenerative dentistry.

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Recent Advances in Nanodentistry

Cited by 3 publications

References 98 publications

Sinking Our Teeth in Getting Dental Stem Cells to Clinics for Bone Regeneration

Sinking Our Teeth in Getting Dental Stem Cells to Clinics for Bone Regeneration

Effect of Hydro- abrasion versus Conventional Cavity Preparation on the Clinical Performance of Composite Resin Restoration

Tooth Formation: Are the Hardest Tissues of Human Body Hard to Regenerate?

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