Recent advances in nanomaterial-based augmented sonodynamic therapy of cancer

Um, Wooram; K, Pramod Kumar E; Lee, Jeongjin; Kim, Chan Ho; You, Dong Gil; Park, Jae Hyung

doi:10.1039/d0cc07750j

Cited by 80 publications

(57 citation statements)

References 124 publications

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“…Silicon is a part of various body tissues and is mostly important for bones, cartilage, and connective tissue well-being with a total amount of 7 g in the human body. Currently, a variety of SiNPs is developed for different biological applications [18][19][20]. Biodegradability and biocompatibility as well as the possibility to obtain SiNPs of various structures make silicon a promising material for use in the various fields of science, technology, and medicine.…”

Section: Introductionmentioning

confidence: 99%

Silicon–Gold Nanoparticles Affect Wharton’s Jelly Phenotype and Secretome during Tri-Lineage Differentiation

Svirshchevskaya

Sharonova

Полтавцева

et al. 2022

IJMS

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Multiple studies have demonstrated that various nanoparticles (NPs) stimulate osteogenic differentiation of mesenchymal stem cells (MSCs) and inhibit adipogenic ones. The mechanisms of these effects are not determined. The aim of this paper was to estimate Wharton’s Jelly MSCs phenotype and humoral factor production during tri-lineage differentiation per se and in the presence of silicon–gold NPs. Silicon (SiNPs), gold (AuNPs), and 10% Au-doped Si nanoparticles (SiAuNPs) were synthesized by laser ablation, characterized, and studied in MSC cultures before and during differentiation. Humoral factor production (n = 41) was analyzed by Luminex technology. NPs were nontoxic, did not induce ROS production, and stimulated G-CSF, GM-CSF, VEGF, CXCL1 (GRO) production in four day MSC cultures. During MSC differentiation, all NPs stimulated CD13 and CD90 expression in osteogenic cultures. MSC differentiation resulted in a decrease in multiple humoral factor production to day 14 of incubation. NPs did not significantly affect the production in chondrogenic cultures and stimulated it in both osteogenic and adipogenic ones. The major difference in the protein production between osteogenic and adipogenic MSC cultures in the presence of NPs was VEGF level, which was unaffected in osteogenic cells and 4–9 times increased in adipogenic ones. The effects of NPs decreased in a row AuNPs > SiAuNPs > SiNPs. Taken collectively, high expression of CD13 and CD90 by MSCs and critical level of VEGF production can, at least, partially explain the stimulatory effect of NPs on MSC osteogenic differentiation.

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Section: Introductionmentioning

confidence: 99%

Silicon–Gold Nanoparticles Affect Wharton’s Jelly Phenotype and Secretome during Tri-Lineage Differentiation

Svirshchevskaya

Sharonova

Полтавцева

et al. 2022

IJMS

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“…The effect of the sonosensitizer in conjunction with the US promotes the apoptosis of tumor cells. SDT is effective in treating a variety of tumors (Um et al, 2021). Recently, the application of SDT has been studied extensively (Wang et al, 2021), and our team also showed that SDT could promote cell apoptosis through the mitochondrial pathway in HCC cells (Yang et al, 2021).…”

Section: Introductionmentioning

confidence: 75%

RNA-Seq Technology Reveals the Mechanism of SDT Combined With Novel Nanobubbles Against HCC

Shang

Chen

Wang

et al. 2022

Front. Mol. Biosci.

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Sonodynamic therapy is widely used in the treatment and research of hepatocellular carcinoma. A novel targeted nanobubble complex mediated with Hematoporphyrin monomethyl ether and Lonidamine was structured as a sensitizer, characterized the properties, and studied the therapeutic effect on hepatocellular carcinoma. The complexes can promote the apoptosis of hepatocellular carcinoma cells and work better in combination with sonodynamic therapy. The differential expression of multiple types of RNA in hepatocellular carcinoma with sonodynamic therapy can be identified accurately with high-throughput RNA sequencing. The differential expressions of mRNA, lncRNA, and circRNA were analyzed by RNA-Seq. The enrichment analyses (Gene Ontology and KEGG) prompted the meaningful genes and pathways in the process of sonodynamic therapy in hepatocellular carcinoma cells. HMME-LND@C3F8-NBs conjugated with ultrasound is confirmed efficiently for inhibiting the development of hepatocellular carcinoma cells, and it is a combination of multiple genes and mechanisms.

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“…Sonodynamic therapy (SDT) consists of the synergetic action between sound and a chemical agent, usually to trigger the release of reactive oxygen species (ROS) to induce cellular damage [ 85 , 86 , 87 ]. SDT partly relies on intratumoral oxygen availability, which is a specific challenge in the pancreas due to the intrinsic hypoxia in PDAC.…”

Section: Sonodynamic Therapymentioning

confidence: 99%

Pancreatic Ductal Adenocarcinoma: Current and Emerging Therapeutic Uses of Focused Ultrasound

Lafond

Lambin

Drainville

et al. 2022

Cancers

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Pancreatic ductal adenocarcinoma (PDAC) diagnosis accompanies a somber prognosis for the patient, with dismal survival odds: 5% at 5 years. Despite extensive research, PDAC is expected to become the second leading cause of mortality by cancer by 2030. Ultrasound (US) has been used successfully in treating other types of cancer and evidence is flourishing that it could benefit PDAC patients. High-intensity focused US (HIFU) is currently used for pain management in palliative care. In addition, clinical work is being performed to use US to downstage borderline resectable tumors and increase the proportion of patients eligible for surgical ablation. Focused US (FUS) can also induce mechanical effects, which may elicit an anti-tumor response through disruption of the stroma and can be used for targeted drug delivery. More recently, sonodynamic therapy (akin to photodynamic therapy) and immunomodulation have brought new perspectives in treating PDAC. The aim of this review is to summarize the current state of those techniques and share our opinion on their future and challenges.

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Recent advances in nanomaterial-based augmented sonodynamic therapy of cancer

Abstract: This review focuses on recent advances in augmented sonodynamic therapy (SDT) using engineered nanomaterials, and the mechanism of SDT for discussing future perspectives.

Cited by 80 publications

References 124 publications

Silicon–Gold Nanoparticles Affect Wharton’s Jelly Phenotype and Secretome during Tri-Lineage Differentiation

Silicon–Gold Nanoparticles Affect Wharton’s Jelly Phenotype and Secretome during Tri-Lineage Differentiation

RNA-Seq Technology Reveals the Mechanism of SDT Combined With Novel Nanobubbles Against HCC

Pancreatic Ductal Adenocarcinoma: Current and Emerging Therapeutic Uses of Focused Ultrasound

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