Recent Advances in Nanoparticle-Based Cancer Treatment: A Review

Bajpai, Sushant; Tiwary, Saurabh Kr; Sonker, Muskan; Joshi, Ayush; Gupta, Vishwas; Kumar, Yogendra; Shreyash, Nehil; Biswas, Susham

doi:10.1021/acsanm.1c00779

Cited by 71 publications

(44 citation statements)

References 262 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At present, most of the related preparations of gold nanoparticles are still in the clinical trial stage. Most of the nanogold-related drugs approved for clinical use by the FDA are nanogold combined with anticancer drugs (such as paclitaxel) or related proteins used in cancer treatment and diagnosis [ 73 ]. Currently, clinical trials and basic research on nanogold are in full swing.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications

Wang

Hsiao

et al. 2022

Molecules

View full text Add to dashboard Cite

Gold has always been regarded as a symbol of nobility, and its shiny golden appearance has always attracted the attention of many people. Gold has good ductility, molecular recognition properties, and good biocompatibility. At present, gold is being used in many fields. When gold particles are as small as several nanometers, their physical and chemical properties vary with their size in nanometers. The surface area of a nano-sized gold surface has a special effect. Therefore, gold nanoparticles can, directly and indirectly, give rise to different biological activities. For example, if the surface of the gold is sulfided. Various substances have a strong chemical reactivity and are easy to combine with sulfhydryl groups; hence, nanogold is often used in biomedical testing, disease diagnosis, and gene detection. Nanogold is easy to bind to proteins, such as antibodies, enzymes, or cytokines. In fact, scientists use nanogold to bind special antibodies, as a tool for targeting cancer cells. Gold nanoparticles are also directly cytotoxic to cancer cells. For diseases caused by inflammation and oxidative damage, gold nanoparticles also have antioxidant and anti-inflammatory effects. Based on these unique properties, gold nanoparticles have become the most widely studied metal nanomaterials. Many recent studies have further demonstrated that gold nanoparticles are beneficial for humans, due to their functional pharmacological properties in a variety of diseases. The content of this review will be the application of gold nanoparticles in treating or diagnosing pressing diseases, such as cancers, retinopathy, neurological diseases, skin disorders, bowel diseases, bone cartilage disorders, cardiovascular diseases, infections, and metabolic syndrome. Gold nanoparticles have shown very obvious therapeutic and application potential.

show abstract

Section: Discussionmentioning

confidence: 99%

Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications

Wang

Hsiao

et al. 2022

Molecules

View full text Add to dashboard Cite

show abstract

“…If the CO 2 is collected, the gas stream will be contained deep in geological formations that will keep greenhouse gases from entering the environment as it will be sealed with a natural layer of cap rock having low permeability. The greenhouse gases have been known to cause a myriad of problems in the environment and to the individuals involving a number of diseases and interference in the natural phenomenon [87][88][89] A lot of research has been done to encourage and aid in geological sequestration of carbon. Geological sequestration poses a lot of risks to the environment if it is not regulated properly.…”

Section: Geological Sequestrationmentioning

confidence: 99%

The Review of Carbon Capture-Storage Technologies and Developing Fuel Cells for Enhancing Utilization

et al. 2021

Self Cite

View full text Add to dashboard Cite

The amount of CO2 released in the atmosphere has been at a continuous surge in the last decade, and in order to protect the environment from global warming, it is necessary to employ techniques like carbon capture. Developing technologies like Carbon Capture Utilization and Storage aims at mitigating the CO2 content from the air we breathe and has garnered immense research attention. In this review, the authors have aimed to discuss the various technologies that are being used to capture the CO2 from the atmosphere, store it and further utilize it. For utilization, researchers have developed alternatives to make profits from CO2 by converting it into an asset. The development of newer fuel cells that consume CO2 in exchange for electrical power to drive the industries and produce valuable hydrocarbons in the form of fuel has paved the path for more research in the field of carbon utilization. The primary focus on the article is to inspect the environmental and economic feasibility of novel technologies such as fuel cells, different electrochemical processes, and the integration of artificial intelligence and data science in them, which are designed for mitigating the percentage of CO2 in the air.

show abstract

“…Among them, chemotherapy can be used alone as the first-line treatment, or it can be used in combination with other approaches (Atlihan-Gundogdu et al., 2020 ; Chen et al., 2020 ). For example, chemotherapy is used to reduce the size of tumors prior to surgery, and it can be employed to prevent the proliferation of cancer cells after surgery or radiotherapy (Amjad et al., 2021 ; Bajpai et al., 2021 ). Although these conventional methods achieved clinical success, to a certain extent, in improving the survival rates of cancer patients, they exhibited critical issues with nonspecific tissue distribution of anticancer drugs to both healthy and pathological cells (Yetisgin et al., 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Functional ligands for improving anticancer drug therapy: current status and applications to drug delivery systems

et al. 2022

View full text Add to dashboard Cite

Conventional chemotherapy lacking target selectivity often leads to severe side effects, limiting the effectiveness of chemotherapy. Therefore, drug delivery systems ensuring both selective drug release and efficient intracellular uptake at the target sites are highly demanded in chemotherapy to improve the quality of life of patients with low toxicity. One of the effective approaches for tumor-selective drug delivery is the adoption of functional ligands that can interact with specific receptors overexpressed in malignant cancer cells. Various functional ligands including folic acid, hyaluronic acid, transferrin, peptides, and antibodies, have been extensively explored to develop tumor-selective drug delivery systems. Furthermore, cell-penetrating peptides or ligands for tight junction opening are also actively pursued to improve the intracellular trafficking of anticancer drugs. Sometimes, multiple ligands with different roles are used in combination to enhance the cellular uptake as well as target selectivity of anticancer drugs. In this review, the current status of various functional ligands applicable to improve the effectiveness of cancer chemotherapy is overviewed with a focus on their roles, characteristics, and preclinical/clinical applications.

show abstract

Recent Advances in Nanoparticle-Based Cancer Treatment: A Review

Cited by 71 publications

References 262 publications

Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications

Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications

The Review of Carbon Capture-Storage Technologies and Developing Fuel Cells for Enhancing Utilization

Functional ligands for improving anticancer drug therapy: current status and applications to drug delivery systems

Contact Info

Product

Resources

About