Recent Advances in p53 Research and Cancer Treatment

Suzuki, Kazufumi; Matsubara, Hisahiro

doi:10.1155/2011/978312

Cited by 147 publications

(125 citation statements)

References 66 publications

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“…The analysis of histological situation of neoplasias shows the predominance of low differentiated forms of cancer (the most common malignant tumors of the uterus, thyroid, breast cancer in Ukraine) in woman [16,17]. There are tumors of moderate and high degree of malignancy with increased aggressiveness and the growth of metastatic ability of cancerous tissue in each subsequent accident.…”

Section: Discussionmentioning

confidence: 99%

Primary multiple tumor with affection of the thyroid gland, uterus, urinary bladder, mammary gland and other organs

Романюк

Lyndin

Smiyanov

et al. 2017

Pathology - Research and Practice

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a b s t r a c tBackground: Nowadays multiple primary tumor is characterized by growth and development of two or more tumors in one patient. The total world sickness rate ranges from 1% to 37%. The presence of four or more tumors in one patient is rare case and presented as casuistry. Case presentation: We showed a case of multiple primary tumor with metahronic lesion of the thyroid, uterus and breast, followed by synchronous benign tumors of the subcutaneous fat, urinary bladder and gallbladder were considered. The development of all malignant tumors in all cases was accompanied by the presence of benign precancerous processes. Analysis of neoplasia histology shows the predominance of poorly differentiated forms of cancers in women with increased aggressiveness of cancerous tissue in each subsequent case and the growth of metastatic ability. The influence of heredity on the tumors progress is confirmed by immunohistochemical characteristics of cancer cells. Steroid-sensitive tissue of the uterus and breast in both cases didn't express ER and PR, in all cases the tissue had overexpression of Ki-67, p53, bax and bcl-2 receptors. The results of DNA testing for determination the Lynch syndrome revealed the presence of microsatellite instability in genetic material. The results of studies revealed the absence of mutations in these genes (MLH1, MSH2 and MSH6). Despite the negative results of the study, it doesn't exclude the possibility of Lynch syndrome for 100%, and its presence may be caused by the mutations of other genes (PMS1, PMS2 and MLH3), responsible for DNA repair. Unfortunately there wasn't any opportunity to study their mutations. Conclusions: While studying the anamnesis of life and disease of women it was revealed that she had multiple primary tumor with lesions of the breast, urinary bladder, thyroid, uterus and other organs. This study shows that neoplastic tissue in all cases had high rates of cell proliferation, their antiapoptotic stability, expression of prognostically unfavorable-receptors, and absence of favorable prognostic markers. Histological study revealed high rates of malignant neoplastic tissue. It indicates to the existence of common mechanisms of malignant tumors and their genetic predisposition that can be clearly observed in many generations of patient.

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Section: Discussionmentioning

confidence: 99%

Primary multiple tumor with affection of the thyroid gland, uterus, urinary bladder, mammary gland and other organs

Романюк

Lyndin

Smiyanov

et al. 2017

Pathology - Research and Practice

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“…Ovaj protein se nagomilava u tumorskim ćelijama i može se dokazati imunohistohemijskim metodama. Kod bolesnika sa pozitivnim p53 preživ-ljavanje je bilo statistički značajno lošije nego kod bolesnika sa negativnim p53 (52,5 % vs. 94,1%) [6][7][8][9].…”

Section: Uvodunclassified

“…Nekoliko studija ispituje korelaciju između ekspresije proteina p53 i apoptoze kod kolorektalnih neoplazmi [5,6]. U našoj studiji analiza preživljavanja pacijenata u periodu od 7 godina pokazala je statistički značajnu razliku u preživljavanju pacijenata sa jako pozitivnim vrijednostima p53 i slabo pozitivnim vrijednostima p53 (p < 0,001).…”

Section: Diskusijaunclassified

Immunohistochemical markers: Carcinoembryonic antigen, p53, Ki-67, and proliferating cell nuclear antigen as prognostic factors for colorectal cancer

Maksimović¹,

Jakovljević²,

Gojkovic³

et al. 2018

Biomedicinska istraž.

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Kratak sadržajUvod. Učestalost karcinoma kolona i rektuma je u postupnom porastu posljednjih dvadeset godina. Da bi procjena ljekara o trajanju života pacijenata i/ili liječenju bila što preciznija, u onkologiji se koriste faktori prognoze i predikcije. Oni se mogu klasifikovati na: kliničko-hirurške, patološko-histološke i imunohistohemijske. Cilj rada je bio utvrditi značaj imunohistohemijskih markera -karcinoembrionalnog antigena (CEA), p53, Ki-67 i proliferišućeg nuklearnog antigena (PCNA) u predikciji preživljavanja pacijenata sa karcinomom kolona i rektuma.Metode. Od 1. januara 2010. godine do 1. decembra 2017. godine u Javnoj zdravstvenoj ustanovi bolnici "Sveti Vračevi" u Bijeljini liječeno je 484 pacijenata sa karcinomima kolona i rektuma kojima je u tkivu karcinoma imunohistohemijskom analizom ispitana ekspresija CEA, p53, Ki-67 i PCNA.Rezultati. Imunohistohemijska analiza tkiva primarnog kolorektalnog adenokarcinoma ispitivanih pacijenata pokazala je jako pozitivnu ekspresiju CEA kod 301 (62%) pacijenta, p53 kod 329 (68%), PCNA kod 314 i Ki-67 kod 275 (56,8%) pacijenata. Pacijenti sa jako pozitivnom ekspresijom CEA, p53 i PCNA su imali statistički značajno lošije preživljavanje u odnosu na pacijente sa slabom ekspresijom ovih imunohistohemijskih markera. Nema statistički značajne razlike u preživljavanju pacijenata sa jako pozitivnim imunohistohemijskim skorom Ki-67 u odnosu na pacijente sa slabo pozitivnim vrijednostima skora.Zaključak. Imunohistohemijska analiza se ne koristi u rutinskoj analizi karcinoma kolona i rektuma, iako imunohistohemijski markeri predstavljaju korisne prediktore preživljavanja pacijenata.Ključne riječi: imunohistohemijski markeri, CEA, p53, Ki-67, PCNA, kolorektalni karcinom, preživljavanje

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“…Furthermore, most evidence suggests that the key contribution of p53 to apoptosis is primarily dependent on transcriptional activity. p53 has the ability to activate transcription of various proapoptotic genes, including those encoding members of the Bcl-2 family, such as the BH-3 only proteins Bax, Noxa, and Puma [31]. In addition, it has been found that when the p53 mutant was silenced, it resulted in reduced cellular colony growth in human cancer cells, which was found to be due to the induction of apoptosis.…”

Section: P53mentioning

confidence: 99%

Apoptosis-Biochemistry: A Mini Review

Jayakiran¹

2015

J Clin Exp Pathol

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Apoptosis or programmed cell death is a normal component of the development and health of multicellular organisms. Homeostasis is maintained through a balance between cell proliferation and cell death. It is a process of controlled cellular death whereby the activation of specific death-signaling pathways leads to deletion of cells from tissue. The distinct morphological features of apoptosis are Cell shrinkage, Chromatin condensation, Membrane blebbing and formation of apoptotic bodies, which are phagocytosed by neighbouring macrophages without any inflammatory response. Derailment of apoptosis in regulation can lead to several diseases or ailments with either too much or too little apoptosis. Understanding the molecular mechanism of apoptosis including death genes, death signals, surface receptors and signal pathways will provide new insights in developing strategies to regulate cell survival/death. The current knowledge on the molecular events of apoptotic cell death and their significance in health and disease is reviewed.

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Recent Advances in p53 Research and Cancer Treatment

Cited by 147 publications

References 66 publications

Primary multiple tumor with affection of the thyroid gland, uterus, urinary bladder, mammary gland and other organs

Primary multiple tumor with affection of the thyroid gland, uterus, urinary bladder, mammary gland and other organs

Immunohistochemical markers: Carcinoembryonic antigen, p53, Ki-67, and proliferating cell nuclear antigen as prognostic factors for colorectal cancer

Apoptosis-Biochemistry: A Mini Review

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