Recent Advances in Pediatric Pulmonary Hypertension: Implications for Diagnosis and Treatment

Sullivan, Rachel T.; Raj, J. Usha; Austin, Eric D.

doi:10.1016/j.clinthera.2023.07.001

Clinical Therapeutics

2023

DOI: 10.1016/j.clinthera.2023.07.001

|View full text |Cite

Recent Advances in Pediatric Pulmonary Hypertension: Implications for Diagnosis and Treatment

Rachel T. Sullivan¹,

J. Usha Raj²,

Eric D. Austin³

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 6 publications

References 164 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Extracorporeal membrane oxygenation (ECMO) support for children with pulmonary hypertension: A single‐institutional experience of outcomes

Nemeh,

Schmoke,

Patten

et al. 2024

Pulm. circ.

View full text Add to dashboard Cite

Pediatric pulmonary arterial hypertension (PAH) can present with a wide spectrum of disease severity. Pulmonary hypertension (PH) crises can lead to acute decompensation requiring extracorporeal membrane oxygenation (ECMO) support, including extracorporeal cardiopulmonary resuscitation (eCPR). We evaluated outcomes for pediatric PH patients requiring ECMO. A single‐institution retrospective review of pediatric PAH patients with World Symposium on PH (WSPH) groups 1 and 3 requiring ECMO cannulation from 2010 through 2022 (n = 20) was performed. Primary outcome was survival to hospital discharge. Secondary outcomes were survival to decannulation and 1‐year survival. Of 20 ECMO patients, 16 (80%) survived to decannulation and 8 (40%) survived to discharge and 1 year follow up. Of three patients who had two ECMO runs; none survived. There were five patients who had eCPR for the first run; one survived to discharge. The univariate logistic regression model showed that venovenous ECMO was associated with better survival to hospital discharge than venoarterial ECMO, (OR: 0.12, 95% CI: 0.01–0.86, p = 0.046). PH medications (administered before, during, or after ECMO) were not associated with survival to discharge. For children with decompensated PAH requiring ECMO, mortality rate is high, and management is challenging. While VA ECMO is the main configuration for decompensated PH, VV ECMO could be considered if there is adequate ventricular function, presence of a systemic to pulmonary shunt, or an intercurrent treatable illness to improve survival to discharge. A multidisciplinary approach with requisite expertise should be utilized on a case‐by‐case basis until more reliable data is available to predict outcomes.

show abstract

Extracorporeal membrane oxygenation (ECMO) support for children with pulmonary hypertension: A single‐institutional experience of outcomes

Nemeh,

Schmoke,

Patten

et al. 2024

Pulm. circ.

View full text Add to dashboard Cite

show abstract

Magnetic resonance imaging of pulmonary hypertension

Kellenberger

2024

Pediatr Radiol

View full text Add to dashboard Cite

Pulmonary hypertension is a rare but serious disease in children with potentially poor prognosis in the long term. Direct measurement of increased pressure in the pulmonary circulation requires right-heart catheterisation. Echocardiography is the imaging modality commonly used for suggesting the presence of pulmonary hypertension and estimating its severity. Recognition of structural and haemodynamic signs of increased pulmonary arterial pressure and pressure overload of the right ventricle at magnetic resonance (MR) imaging may contribute to the diagnosis of pulmonary hypertension and management of these patients. In this article, the structural, functional, and haemodynamic cardiovascular MR findings of paediatric pulmonary hypertension are reviewed. Typical diagnostic MR scenarios in children with suspected pulmonary hypertension or in children with disease associated with pulmonary hypertension are presented and discussed. Graphical Abstract

show abstract

Pulmonary Hypertension in Children

Sullivan,

Austin

2024

Clinics in Chest Medicine

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Recent Advances in Pediatric Pulmonary Hypertension: Implications for Diagnosis and Treatment

Cited by 6 publications

References 164 publications

Extracorporeal membrane oxygenation (ECMO) support for children with pulmonary hypertension: A single‐institutional experience of outcomes

Extracorporeal membrane oxygenation (ECMO) support for children with pulmonary hypertension: A single‐institutional experience of outcomes

Magnetic resonance imaging of pulmonary hypertension

Pulmonary Hypertension in Children

Contact Info

Product

Resources

About