Recent Advances in Pharmaceutical Approaches of Antimicrobial Agents for Selective Delivery in Various Administration Routes

Marzaman, Ardiyah Nurul Fitri; Roska, Tri Puspita; Sartini, Sartini; Utami, Rifka Nurul; Sulistiawati, Sulistiawati; Enggi, Cindy Kristina; Manggau, Marianti A.; Rahman, Latifah; Shastri, V. Prasad; Permana, Andi Dian

doi:10.3390/antibiotics12050822

Cited by 6 publications

(1 citation statement)

References 332 publications

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“…Liquid crystals are an ideal mechanism of drug delivery for ATDs. Liquid crystal-based zidovudine, ciprofloxacin, and fluconazole formulations are some of the recent developments in the antimicrobial field, making them a possible approach for delivering ATDs as well [135]. K. Dua et al synthesized RIF-based liquid crystals with higher solubility and stability in acidic environments than the free drug, allowing for lower dose frequency and increased bioavailability.…”

Section: Liquid Crystalsmentioning

confidence: 99%

Advanced drug delivery and therapeutic strategies for tuberculosis treatment

Nair,

Greeny,

Nandan

et al. 2023

J Nanobiotechnol

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Tuberculosis (TB) remains a significant global health challenge, necessitating innovative approaches for effective treatment. Conventional TB therapy encounters several limitations, including extended treatment duration, drug resistance, patient noncompliance, poor bioavailability, and suboptimal targeting. Advanced drug delivery strategies have emerged as a promising approach to address these challenges. They have the potential to enhance therapeutic outcomes and improve TB patient compliance by providing benefits such as multiple drug encapsulation, sustained release, targeted delivery, reduced dosing frequency, and minimal side effects. This review examines the current landscape of drug delivery strategies for effective TB management, specifically highlighting lipid nanoparticles, polymer nanoparticles, inorganic nanoparticles, emulsion-based systems, carbon nanotubes, graphene, and hydrogels as promising approaches. Furthermore, emerging therapeutic strategies like targeted therapy, long-acting therapeutics, extrapulmonary therapy, phototherapy, and immunotherapy are emphasized. The review also discusses the future trajectory and challenges of developing drug delivery systems for TB. In conclusion, nanomedicine has made substantial progress in addressing the challenges posed by conventional TB drugs. Moreover, by harnessing the unique targeting abilities, extended duration of action, and specificity of advanced therapeutics, innovative solutions are offered that have the potential to revolutionize TB therapy, thereby enhancing treatment outcomes and patient compliance. Graphical Abstract

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Section: Liquid Crystalsmentioning

confidence: 99%

Advanced drug delivery and therapeutic strategies for tuberculosis treatment

Nair,

Greeny,

Nandan

et al. 2023

J Nanobiotechnol

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Efficacy Assessment of Molecularly Imprinted Polymer Incorporated with Starch and Macadamia Capped Silver Nanoparticles for the Removal of Multi‐Class Pharmaceuticals in Wastewater

Nxumalo,

Mahlambi,

Mahlambi

2024

ChemistrySelect

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The presence of pharmaceuticals in water bodies has been reported to be mainly due to their incomplete removal by the conventional wastewater treatment processes, resulting to their release into the aquatic environment where they thratens to human health and aquatic life. Therefore, it is important to remove these pollutants from the aquatic environment using affordable highly efficient materials. The goal of this study was to incorporate silver nanoparticles (AgNPs) into MIPs for selective removal of sulfamethoxazole, nevirapine, and ibuprofen in wastewater. The AgNPs were synthesized using starch (St) and macadamia (MCD) as both reducing and stabilizing agents. Thermogravimetric analysis showed high stability for the St/MCD‐nanoMIPs. The ANOVA analysis revealed that the parameters affecting adsorption of St/MCD‐nanoMIPs have a significant difference (p<0.05). The St/MCD‐AgNPs experimental data fitted to both Langmuir and Freundlich adsorption isotherms, however, the non‐linear Langmuir isotherm model yielded a better fit based on the higher R2 value (0.999). The non‐linear Freundlich model best fitted for the St/MCD‐nanoMIPs. The linear pseudo‐second order model shown best fit for St/MCD‐nanoMIPs, the thermodynamic results revealed that the adsorption process was spontaneous and endothermic. The St/MCD‐nanoMIPs showed improved qualities and were highly selective (>70 %) and effective in removing the selected pharmaceuticals from wastewater.

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