Recent advances in photorelease complexes for therapeutic applications

Abstract

Photorelease complexes represent a class of agents for which UV-visible light triggers the expulsion of a specfic molecule that is intrinsically part of the inner coordination sphere or held in...

Bichromophoric ruthenium(ii) bis-terpyridine-BODIPY based photosensitizers for cellular imaging and photodynamic therapy

“…12 Among them, Ru( ii ) polypyridyl complexes were the most studied ones for their superior properties like water solubility and photobleaching resistance compared to their organic counterparts. 13 The most salient feature of such complexes is the heavy atom effect exerted by the central metal atom that promotes intersystem crossing (ISC), which improves ROS sensitization efficiency. Notably, a Ru( ii ) polypyridyl complex TLD-1433 has recently entered in a phase II clinical trial for the PDT treatment of bladder cancer.…”