Recent Advances in Plant DNA Repair

Abstract

NaCl (abiotic stress). Its expression increased fivefold in the first hour and then an interactome analysis indicated that OsSUV3 plays an important role in other pathways [18]. These are some examples that show the connection among the DNA repair machinery, stress tolerance, and the ROS production ( Figure 2) [11][12][13][14][15]."Omics" are a powerful tool to identify genes/proteins/metabolites that are involved in the plant response to a specific stress and/or to a DNA repair pathway [19]. Besides, transgenic and mutant plants are also helping in the gene characterization function. The data have shown that plant response is more complicated than previously thought. Not only is the presence of transcript (tissue or time presence) important, but also the signals are important for gene regulation, post-translation modifications (ubiquitination or sumolation), protein degradation, and protein targeting. All these may change when plants are exposed to different environmental conditions [19][20][21][22][23]. Furthermore, the next generation sequence data have shown that the signal transduction pathways actually form a network and the different networks are interconnected [24][25]. miRNAs have also been connected as a key factor for plant response to the stress and tolerance mechanism [25-28].Considering the importance of the plants for food production, it is important to identify which genes/proteins/pathways are involved in these different mechanisms. This knowledge is important for plant breeders to produce new cultivars [17,28]. Moreover, considering all that was explained above, plants are an interesting model to study stresses and DNA repair ( Figure 2) due their sessile condition, genome plasticity, and the fact that these organisms do not have a germinative cell lineage. The apical meristem cells (shoot or root) suffer division continually during plant development and then genome integrity is extremely important [2]. Then, this chapter will focus on DNA repair pathways in plants.This figure illustrates different abiotic factors such as drought, heavy metals, light, heat, ozone, lack of nutrients, cold, freezing, etc. Plants are able to perceive these different conditions or signals (on the right side) and then promote different molecular and physiological responses, which involve changes in gene expression, protein translation, post-translation modifications, degradation, epigenetic changes, and miRNAs. All these together produce a plant response that helps plants to tolerate this stress condition. Represented on the left side are the effects of an imbalance of ROS in DNA repair and the different DNA repair and genes that are involved in these different processes. The DNA repair presented in this figure includes mismatch repair (MMR), excision repair (NER and BER), and double strand breaks (HR and NHEJ).

A Large-Scale Candidate-Gene Association Mapping for Drought Tolerance and Agronomic Traits in Sugarcane

“…Third, SNP22843 is located on the Sh06_g020100 gene annotated as DNA mismatch repair protein MSH3. The MSH3 is involved in correcting DNA replication errors and maintaining the genome integrity in plants under environmental stresses [ 72 ]. The overexpression of DNA repair genes in transgenic plants makes these plants more tolerant of drought, salinity, and other stress conditions [ 73 , 74 ].…”

Oxidative and Glycation Damage to Mitochondrial DNA and Plastid DNA during Plant Development

“…Mitochondria and chloroplasts possess DNA repair pathways similar to most nuclear ones. Proteins associated with orgDNA repair are encoded exclusively by the nuclear genome [ 3 , 36 , 37 ]. These repair systems include base-excision repair (BER) in Arabidopsis plastids and mitochondria [ 3 , 38 ] and Arabidopsis organellar DNA polymerases, mediating microhomology-mediated end-joining [ 39 ].…”