Recent Advances in Skin Penetration Enhancers for Transdermal Gene and Drug Delivery

Amjadi, Morteza; Mostaghaci, Babak; Sitti, Metin

doi:10.2174/1566523217666170510151540

Cited by 50 publications

(26 citation statements)

References 84 publications

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“…Therefore, these structures may represent a potential target for nanomaterial-based shuttles, as reported by Xuan et al, who showed accumulation of fluorescent MSNs in the hair follicles of porcine ear skin [44]. However, toxicological issues on transdermal delivery of nanomaterials are still under debate [44,45,46]. It is well established that size, shape, surface charge, z potential, and tendency to aggregate are crucial parameters affecting the interactions of NPs with human skin surface.…”

Section: Msns In Topical Drug Deliverymentioning

confidence: 99%

Dealing with Skin and Blood-Brain Barriers: The Unconventional Challenges of Mesoporous Silica Nanoparticles

et al. 2018

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Advances in nanotechnology for drug delivery are fostering significant progress in medicine and diagnostics. The multidisciplinary nature of the nanotechnology field encouraged the development of innovative strategies and materials to treat a wide range of diseases in a highly specific way, which allows reducing the drug dosage and, consequently, improving the patient’s compliance. Due to their good biocompatibility, easy synthesis, and high versatility, inorganic frameworks represent a valid tool to achieve this aim. In this context, Mesoporous Silica Nanoparticles (MSNs) are emerging in the biomedical field. For their ordered porosity and high functionalizable surface, achievable with an inexpensive synthesis process and being non-hazardous to biological tissues, MSNs offer ideal solutions to host, protect, and transport drugs to specific target sites. Extensive literature exists on the use of MSNs as targeted vehicles for systemic (chemo) therapy and for imaging/diagnostic purposes. However, the aim of this review is to give an overview of the last updates on the potential applications of the MSNs for Topical Drug Delivery (TDD) and as drug delivery systems into the brain, discussing their performances and advantages in dealing with these intriguing biological barriers.

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Section: Msns In Topical Drug Deliverymentioning

confidence: 99%

Dealing with Skin and Blood-Brain Barriers: The Unconventional Challenges of Mesoporous Silica Nanoparticles

et al. 2018

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“…Transdermal drug delivery has made a significant contribution to medical practice, but didn't yet achieve its potential as an alternative to hypodermic injections and oral delivery. The penetration of therapeutic compounds into the skin is impeded by the impermeability of the outermost layer of the skin, named stratum corneum (Amjadi, Mostaghaci, Sitti, 2017). Liposomes are efficient for the transdermal drug delivery as they are capable to control the release of the therapeutic agent.…”

Section: Introductionmentioning

confidence: 99%

Niosomes and liposomes as promising carriers for dermal delivery of Annona squamosa extract

Mohamad

Fahmy

2020

Braz. J. Pharm. Sci.

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The leaf extract of Annona squamosa L. has antibacterial, antidiabetic, antioxidant, and anticancerous activities. The present work aims to compare between liposomes and niosomes as carriers for A. squamosa extract to improve its transdermal bioavailability. Physical characterization for niosomes and liposomes was performed using: transmission electron microscope (TEM), scanning electron microscope (SEM) and Fourier transform infrared spectroscopy (FTIR). In addition, the encapsulation efficiency for A. squamosa in both carriers was evaluated and in-vitro drug release experiments were performed. The results proved the potential of both carriers to penetrate the outer layer of the skin (stratum corneum) which is considered as a strong barrier against the diffusion of many compounds through the skin. Moreover, the results pointed out that niosomes and liposomes lasted long time through the skin, which ensures the presence of antioxidant extract in the skin for prolonged periods. This would have a benefit of targeting free radicals in the skin. The encapsulation efficiency of liposomes for A. squamosa extract exceeded that of niosomes, however, niosomes demonstrated longer time of drug release through the skin. In conclusion, niosomes and liposomes are promising carriers for dermal delivery of the antioxidant extract Annona squamosa.

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“…Transdermal drug delivery is a more selective and targeted delivery method in clinical practice. It can be used to continuously transport drugs through the skin, without using invasive and painful hypodermic injections, and has comparatively fewer systemic side effects compared with oral delivery [ 2 , 3 ]. For these reasons, topical and transdermal delivery systems of drug administration for systemic therapeutic effects are gaining attention.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Percutaneous Absorption of Drug Molecules in Zebrafish

Morikane¹,

Zang

2020

Molecules

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In recent decades, zebrafish (Danio rerio) has become a widely used vertebrate animal model for studying development and human diseases. However, studies on skin medication using zebrafish are rare. Here, we developed a novel protocol for percutaneous absorption of molecules via the zebrafish tail skin, by applying a liquid solution directly, or using a filter paper imbibed with a chemical solution (coating). Human skin is capable of absorbing felbinac and loxoprofen sodium hydrate (LSH), but not glycyrrhetinic acid (GA) and terbinafine hydrochloride (TH). To evaluate the possibility and the quality of transdermal absorption in zebrafish, we transdermally administered these four drugs to zebrafish. Pharmacokinetics showed that felbinac was present in the blood of zebrafish subjected to all administration methods. Felbinac blood concentrations peaked at 2 h and disappeared 7 h after administration. GA was not detected following transdermal administrations, but was following exposure. LSH was not found in the circulatory system after transdermal administration, but TH was. A dose-response correlation was observed for felbinac blood concentration. These findings suggest that zebrafish are capable of absorbing drug molecules through their skin. However, the present data cannot demonstrate that zebrafish is a practical model to predict human skin absorption. Further systemic studies are needed to observe the correlations in percutaneous absorption between humans and zebrafish.

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Recent Advances in Skin Penetration Enhancers for Transdermal Gene and Drug Delivery

Cited by 50 publications

References 84 publications

Dealing with Skin and Blood-Brain Barriers: The Unconventional Challenges of Mesoporous Silica Nanoparticles

Dealing with Skin and Blood-Brain Barriers: The Unconventional Challenges of Mesoporous Silica Nanoparticles

Niosomes and liposomes as promising carriers for dermal delivery of Annona squamosa extract

Evaluation of the Percutaneous Absorption of Drug Molecules in Zebrafish

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