Recent advances in stem cells therapy: A focus on cancer, Parkinson’s and Alzheimer’s

Fleifel, Dalia; Rahmoon, Mai Atef; AlOkda, Abdelrahman; Nasr, Mostafa; Elserafy, Menattallah; El‐Khamisy, Sherif F.

doi:10.1016/j.jgeb.2018.09.002

Cited by 34 publications

(23 citation statements)

References 100 publications

(114 reference statements)

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“…c) Ganciclovir drug is converted to its phosphorylated forms which blocks the DNA synthesis via thymidine kinase enzyme. These systems in mouse model has shown to be efficient in the treatment of brain, breast, ovarian, and prostate cancer [16].…”

Section: Recent Advances In the Field Of Stem Cell Researchmentioning

confidence: 99%

“…A recent clinical study revealed that the combination of using T-VEC oncolytic virotherapy with immunotherapy has an increased drift of T cells towards tumour vicinity. A group of researchers managed to edit HLA genes in human Embryonic Stem Cells (hESCs) in vitro using zinc-finger nucleases, enabling the ESCs to evade the HLA-restricted cytotoxic T-lymphocytes [16].…”

Section: Recent Advances In the Field Of Stem Cell Researchmentioning

confidence: 99%

“…(iv) Stem cell-based therapy in fighting cancer In 2013, HLA gene editing was successfully done in human embryonic stem cells by using zincfinger nucleases, which enabled the embryonic stem cells to escape the HLA-restricted cytotoxic Tlymphocytes, indicating the way towards generating universal cells from allogenic donors [16].…”

Section: Recent Advances In the Field Of Stem Cell Researchmentioning

confidence: 99%

“…There are experimental evidences for the derivation of neural stem cells from the neonatal rat's hippocampus which were implanted in the brain of Alzheimer's disease rat models. This neural stem cells were found to be able to differentiate into new cholinergic neurons with improved ability of spatial learning and memory to counter the Alzheimer's disease [16].…”

Section: Recent Advances In the Field Of Stem Cell Researchmentioning

confidence: 99%

“…Another way of treating cancer is by the modification of stem cells such as Mesenchymal Stem Cells that show tumour-tropic properties that stimulate immune response against cancer. For example, human MSCs were modified to produce IL-12 and IL-18, which was reported to have an immune response against cervical cancer, renal cell carcinoma and glioblastoma through the activation of natural killer cells and tumour-specific T cells in mice[16]. (ii) Stem cell-mediated suicide gene therapy Inactive forms of anticancer drugs are converted into active forms only at the tumour site by genetically engineered stem cells, this process is known as stem cell-mediated suicide gene therapy.…”

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confidence: 99%

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Bioethical Issues in Stem Cell Research

Panigrahy¹,

Sinha²,

Patil³

et al. 2020

Global Bioethics Enquiry Journal

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A rapid growth and progress in the field of biotechnology have also added a number of ethical and policy issues particularly related to stem cell research. The stem cells have the potential to differentiate into different types of specialized cells and tissues in our body. The human derived stem cells are pluripotent having a great potential to be used as regenerative medicine and cell replacement therapies useful for the treatment of many diseases. This possibility is more effective when these stem cells are derived from human embryos. It is important that the embryonic stem cells must be obtained from early human embryos. It means that a potential human life needs to be destroyed for saving the life of another person. This raises a number of ethical issues and as we proceed towards the future in stem cell research closer to clinical use. There will be more ethical issues arising related to accessibility to the patients and its efficiency. In this article we have discussed the earlier and the current status covering the most significant bioethical issues related to stem cell research.

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Section: Recent Advances In the Field Of Stem Cell Researchmentioning

confidence: 99%

Section: Recent Advances In the Field Of Stem Cell Researchmentioning

confidence: 99%

Section: Recent Advances In the Field Of Stem Cell Researchmentioning

confidence: 99%

Section: Recent Advances In the Field Of Stem Cell Researchmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Bioethical Issues in Stem Cell Research

Panigrahy¹,

Sinha²,

Patil³

et al. 2020

Global Bioethics Enquiry Journal

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A consolidated review on stem cell therapy for treatment and management of Alzheimer's disease

Ahmad

Sachdeva

2022

Aging Medicine

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Memory loss, emotional fluctuations, and functioning impairments are frequent signs of Alzheimer's disease (AD). Dementia, which includes AD, affects 50 million people worldwide, the majority of whom are elderly. AD is the world's fifth biggest cause of mortality, according to the World Health Organization (WHO), with the number of fatalities expected to quadruple by 2050 if present trend continue. 1,2 Brain imaging, physical and cognitive examinations, laboratory testing, and medical history are used to diagnose AD. 3 Risk factors of the AD include apolipoprotein E4 (APOE4) genotype and traumatic brain injury, family history and age, obesity, diabetes, hypercholesterolemia, hypertension, and illiteracy. The most prevalent causes of AD are mutations in the genes producing the amyloid precursor protein (APP), presenilin 2 (PSEN2), and presenilin 1 (PSEN1). 4 As a result, both pharmaceutical and nonpharmacological therapies, such as physical, social, and cognitive activities, should be included in the treatment plan. Lithium and sodium valproate are two medicines used to treat mild to severe cognitive impairment. 5,6 Nonsteroidal anti-inflammatory medications (NSAIDs) like naproxen and ibuprofen are also used to treat neuroinflammation and prevent neurodegeneration. 7,8 Ganstigmine, metrifonate, lecithin, ibuprofen, rofecoxib, latrepiridine, omega-3 polyunsaturated fatty acids, vitamin B, and vitamin E are among the medications that have failed clinical studies. These drugs have been linked to headaches, nausea, vomiting, neuromuscular dysfunction, and respiratory problems. 5,9 Only five FDA-approved medications are now available to treat the symptoms of Alzheimer's disease. Aducanumab was just authorized for use in the year 2021. Memantine (N-methyl-D-aspartate receptor) has been on the market for 10 years (NMDAR antagonist). The remaining five medications are rivastigmine, donepezil (both cholinesterase inhibitors [ChEls]), memantine (an NMDAR antagonist), and galantamine (an NMDAR antagonist). 3,10 In recent years, stem cell therapy has exhibited significant progress in treating AD, as seen by multiple improvements in clinical studies. Self-generation, multiplication, division, and reprogramming for multi-lineage activities are among their many astonishing abilities. Consequently, they can be integrated into existing neural network topologies in this fashion.

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Allogeneic Fibrin Clot for Odontogenic/Cementogenic Differentiation of Human Dental Mesenchymal Stem Cells

Chung

Choung

2020

Tissue Eng Regen Med

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Recent advances in stem cells therapy: A focus on cancer, Parkinson’s and Alzheimer’s

Cited by 34 publications

References 100 publications

Bioethical Issues in Stem Cell Research

Bioethical Issues in Stem Cell Research

A consolidated review on stem cell therapy for treatment and management of Alzheimer's disease

Allogeneic Fibrin Clot for Odontogenic/Cementogenic Differentiation of Human Dental Mesenchymal Stem Cells

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