Recent advances in the biosynthesis of fungal glucan structural diversity

Liu, Jin-Jin; Hou, Yu-Ke; Wang, Xin; Zhou, Xing-Tao; Yin, Jun-Yi; Nie, Shao-Ping

doi:10.1016/j.carbpol.2024.121782

Cited by 10 publications

(2 citation statements)

References 153 publications

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“…This suggested that the biosynthesis of polysaccharides might follow some regularities. Current studies have found that fungal glucans of ascomycete were synthesized by glycosyltransferase on the cell membrane, leading to the formation of the conserved polysaccharide skeleton, while other genes and enzymes involved in glucan synthesis may further stochastically regulate this process, resulting in diverse glucan structure. However, it remains unclear how polysaccharide is synthesized in the basidiomycete due to the difficult cultivation, unclear genetic background, and lack of efficient recombinant methodologies.…”

Section: Discussionmentioning

confidence: 99%

Changes of the Physicochemical Properties and Structural Characteristics of Alkali-Extracted Polysaccharides from Agrocybe cylindracea Across the Growth Process

Liu,

Chen,

Wang

et al. 2024

J. Agric. Food Chem.

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Polysaccharides derived from Agrocybe cylindracea have been demonstrated to exhibit various bioactivities. However, studies on their structural characteristics during the growth process are limited. This study aimed to compare the physicochemical properties and structural characteristics of alkali-extracted polysaccharides from A. cylindracea fruiting bodies (JACP) across four growth stages. Results showed that the extraction yields and protein levels of JACP declined along with the growth of A. cylindracea, while the contents of neutral sugar and glucose increased significantly. However, JACP exhibited structural characteristics similar to those across the four stages. Four polysaccharide subfractions were isolated from each growth stage, including JACP-Et30, JACP-Et50, JACP-Et60, and JACP-Et70. JACP-Et30 from the four stages and JACP-Et50 from the initial three stages were identified as heteroglucans with β-1,3-d-Glcp and β-1,6-d-Glcp residues as main chains, respectively. However, other subfractions were considered as β-1,6-d-glucans containing minor glucuronic acid. These subfractions were predominantly replaced by Glcp residues at the O-3 and O-6 positions. Overall, while JACP exhibited variable physicochemical properties, its structural characteristics remained stable during the growth process, offering new insights into its potential applications in the food and medicinal industries.

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Section: Discussionmentioning

confidence: 99%

Changes of the Physicochemical Properties and Structural Characteristics of Alkali-Extracted Polysaccharides from Agrocybe cylindracea Across the Growth Process

Liu,

Chen,

Wang

et al. 2024

J. Agric. Food Chem.

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“…The biological synthesis of these compounds begins with the synthesis of nucleotide sugars at the cytoplasmic level which are transferred in sequence to a lipid carrier to form assembled repeating units and continue with their subsequent export through the polysaccharide or Wzx/Wzy-dependent pathway [18].…”

Section: Glucansmentioning

confidence: 99%

Bioactive Compounds Produced by Macromycetes for Application in the Pharmaceutical Sector: Patents and Products

Martinez-Burgos,

Montes Montes,

Pozzan

et al. 2024

Fermentation

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It is widely known that mushrooms present several properties with applications in the medicinal and pharmaceutical sectors, including antimicrobial, immunomodulatory, antioxidant, hypotensive, neuroprotective, and anti-inflammatory activities. This article aims to review examples of the bioactive metabolites responsible for those activities, such as polysaccharides, phenols and polyphenols, terpenes, peptides, alkaloids, and steroids, which are produced by several relevant mushroom species. It also discusses their production through solid-state fermentation and submerged fermentation, as well as the processes of obtention of mushroom bioactive extracts and considerations on their stability aiming industrial applications. In addition, the article examines the patent landscape surrounding mushroom-derived bioactives, shedding light on the intellectual property history and innovations driving this field forward. Examples of recently deposited patents in the field are highlighted, as well as the main depositors. China and the United States are the major depositor countries in this field (52% and 35% of patents, respectively), and the principal compounds on the patents are polysaccharides and alkaloids. The article also provides insights into the current market landscape, showcasing mushroom-derived products in the pharmaceutical field available to consumers. From dietary supplements to skincare formulations, the market offerings reflect the growing interest in harnessing the health benefits of mushroom bioactives.

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A comprehensive review on the structure-activity relationships and applications of β-D-glucans

Luo,

Geng,

Feng

et al. 2024

Bioactive Carbohydrates and Dietary Fibre

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Recent advances in the biosynthesis of fungal glucan structural diversity

Cited by 10 publications

References 153 publications

Changes of the Physicochemical Properties and Structural Characteristics of Alkali-Extracted Polysaccharides from Agrocybe cylindracea Across the Growth Process

Changes of the Physicochemical Properties and Structural Characteristics of Alkali-Extracted Polysaccharides from Agrocybe cylindracea Across the Growth Process

Bioactive Compounds Produced by Macromycetes for Application in the Pharmaceutical Sector: Patents and Products

A comprehensive review on the structure-activity relationships and applications of β-D-glucans

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