Recent advances in the concept of paraprobiotics: Nutraceutical/functional properties for promoting children health

Kumar, Harsh; Schütz, Francine; Bhardwaj, Kanchan; Sharma, Ruchi; Nepovimová, Eugenie; Dhanjal, Daljeet Singh; Verma, Rachna; Kumar, Dinesh; Kuča, Kamil; Cruz‐Martins, Natália

doi:10.1080/10408398.2021.1996327

Cited by 18 publications

(16 citation statements)

References 128 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, a research-tested 473 LAB isolates from the genera Lactobacillus , Pediococcus , and Lactococcus showed that 17 Lactobacillus isolates were resistant to at least one tested antibiotic [ 96 ]. More commonly, genes giving resistance to tetracycline, erythromycin, and vancomycin are discovered in lactococci, enterococci, and lactobacilli isolated from fermented meat and milk products, likely because of substandard veterinary methods [ 97 , 98 ]. For example, it was discovered that Lactococcus ( L. lactis ) strains were resistant to tetracycline and erythromycin [ 99 ].…”

Section: Resultsmentioning

confidence: 99%

Competitive Exclusion Bacterial Culture Derived from the Gut Microbiome of Nile Tilapia (Oreochromis niloticus) as a Resource to Efficiently Recover Probiotic Strains: Taxonomic, Genomic, and Functional Proof of Concept

et al. 2022

View full text Add to dashboard Cite

This study aims to mine a previously developed continuous-flow competitive exclusion culture (CFCEC) originating from the Tilapia gut microbiome as a rational and efficient autochthonous probiotic strain recovery source. Three isolated strains were tested on their adaptability to host gastrointestinal conditions, their antibacterial activities against aquaculture bacterial pathogens, and their antibiotic susceptibility patterns. Their genomes were fully sequenced, assembled, annotated, and relevant functions inferred, such as those related to pinpointed probiotic activities and phylogenomic comparative analyses to the closer reported strains/species relatives. The strains are possible candidates of novel genus/species taxa inside Lactococcus spp. and Priestia spp. (previously known as Bacillus spp.) These results were consistent with reports on strains inside these phyla exhibiting probiotic features, and the strains we found are expanding their known diversity. Furthermore, their pangenomes showed that these bacteria have indeed a set of so far uncharacterized genes that may play a role in the antagonism to competing strains or specific symbiotic adaptations to the fish host. In conclusion, CFCEC proved to effectively allow the enrichment and further pure culture isolation of strains with probiotic potential.

show abstract

Section: Resultsmentioning

confidence: 99%

Competitive Exclusion Bacterial Culture Derived from the Gut Microbiome of Nile Tilapia (Oreochromis niloticus) as a Resource to Efficiently Recover Probiotic Strains: Taxonomic, Genomic, and Functional Proof of Concept

et al. 2022

View full text Add to dashboard Cite

show abstract

“…A Lactobacillus cell wall is made up of a thick peptidoglycans (PG) multilayer, several β-1,4-linked N-acetylglucosamine units, and N-acetylmuramic disaccharide pentapeptide units cross-linked with a glycan chain (Fig. 4), where the prime composition of glycan strands and pentapeptides is characteristic for Lactobacillus strains (Kumar et al 2021).…”

Section: Lactobacillus Sp Cell Architecture and Propertiesmentioning

confidence: 99%

“…Moreover, the anionic polymer nature of TA allows the covalent linkage of the TA to peptidoglycans as wall teichoic acid (WTA) or it anchors to cytoplasmic membrane via lipid anchored lipoteichoic acid (LTA) (Teame et al 2020). Several studies have revealed that TA from different species of Lactobacillus shows immunomodulatory effects (Kumar et al 2021). For instance, IL-8 expression is affected by L. plantarum LTA induced via diacylated lipoprotein (Pam2CSK) and demonstrates the anti-inflammatory effect in epithelial cells of human intestine (Noh et al 2015).…”

Section: Lactobacillus Sp Cell Architecture and Propertiesmentioning

confidence: 99%

“…For example, L. rhamnosus RW-9595 M-produced purified EPS shows immuno-suppressive effects via exciting minimum amounts of TNF-α, IL-12, and IL-6, and high amounts of IL-10 in macrophages (Teame et al 2020). Also, the L. plantarum BGCG11 strain shows immuno-suppressive activity by producing EPS antiinflammatory effects (Kumar et al 2021). Generally, EPS exerts immunoregulatory effects, although it also displays some anti-tumor properties.…”

Section: Lactobacillus Sp Cell Architecture and Propertiesmentioning

confidence: 99%

“…paracasei contains S-layer proteins which play a vital role in inhibiting the adhesion of Shigella sonnei to HT-29 cells (Teame et al 2020). Furthermore, the pili binding to intestinal mucus leads to the persistence of the Lactobacillus strain in the GIT (Kumar et al 2021). Lactobacillus sp.…”

Section: Lactobacillus Sp Cell Architecture and Propertiesmentioning

confidence: 99%

See 2 more Smart Citations

Antioxidative potential of Lactobacillus sp. in ameliorating D-galactose-induced aging

Kumar

Bhardwaj

Valko

et al. 2022

Appl Microbiol Biotechnol

Self Cite

View full text Add to dashboard Cite

Aging is a progressive, unalterable physiological degradation process of living organisms, which leads to deterioration of biological function and eventually to senescence. The most prevalent factor responsible for aging is the accumulation of damages resulting from oxidative stress and dysbiosis. D-galactose-induced aging has become a hot topic, and extensive research is being conducted in this area. Published literature has reported that the continuous administration of D-galactose leads to the deterioration of motor and cognitive skills, resembling symptoms of aging. Hence, this procedure is employed as a model for accelerated aging. This review aims to emphasize the effect of D-galactose on various bodily organs and underline the role of the Lactobacillus sp. in the aging process, along with its anti-oxidative potential. A critical consideration to the literature describing animal models that have used the Lactobacillus sp. in amending D-galactose-induced aging is also given. Key points • D-Galactose induces the aging process via decreasing the respiratory chain enzyme activity as well as ATP synthesis, mitochondrial dysfunction, and increased ROS production. • D-Galactose induced aging primarily affects the brain, heart, lung, liver, kidney, and skin. • The anti-oxidative potential of Lactobacillus sp. in improving D-galactose-induced aging in animal models via direct feeding and feeding of Lactobacillus-fermented food.

show abstract

Innovative Food Safety Approaches and Nutraceuticals to Promote Children’s Health on Future Outbreaks with the Reflection of COVID-19

Ayseli,

Çetinkaya,

Ayseli

2024

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

Recent advances in the concept of paraprobiotics: Nutraceutical/functional properties for promoting children health

Cited by 18 publications

References 128 publications

Competitive Exclusion Bacterial Culture Derived from the Gut Microbiome of Nile Tilapia (Oreochromis niloticus) as a Resource to Efficiently Recover Probiotic Strains: Taxonomic, Genomic, and Functional Proof of Concept

Competitive Exclusion Bacterial Culture Derived from the Gut Microbiome of Nile Tilapia (Oreochromis niloticus) as a Resource to Efficiently Recover Probiotic Strains: Taxonomic, Genomic, and Functional Proof of Concept

Antioxidative potential of Lactobacillus sp. in ameliorating D-galactose-induced aging

Innovative Food Safety Approaches and Nutraceuticals to Promote Children’s Health on Future Outbreaks with the Reflection of COVID-19

Contact Info

Product

Resources

About