Recent advances in the construction of nanozyme-based logic gates

Abstract

Nanozymes, nanomaterials with enzyme-like activity, have been considered as promising alternatives of natural enzymes. Molecular logic gates, which can simulate the function of the basic unit of an electronic computer, perform Boolean logic operation in response to chemical, biological, or optical signals. Recently, the combination of nanozymes and logic gates enabled bioinformation processing in a logically controllable way. In the review, recent progress in the construction of nanozyme-based logic gates integrated with their utility in sensing is introduced. Furthermore, the issues and challenges in the construction processes are discussed. It is expected the review will facilitate a comprehensive understanding of nanozyme-based logic systems.

Engineering the Stability of Nanozyme-Catalyzed Product for Colorimetric Logic Gate Operations

“…Over the past few decades, a variety of functional nanomaterials with intrinsic enzyme mimetic activities have been explored, owing to the high stability, low cost, convenient storage, and easy synthesis [1][2][3][4][5][6][7][8]. One of the extensive applications and promising developments for nanozymes is in the biocomputing system, which makes noteworthy progress in the logic gate operations that follow the laws of Boolean algebra [9][10][11][12][13][14]. Recently, Boolean algebra has been widely used in the fields of engineering technology and occupies an irreplaceable position.…”

“…Recently, Boolean algebra has been widely used in the fields of engineering technology and occupies an irreplaceable position. Additionally, according to the presence of input and output signals generated from biological molecules, the Boolean logic gates are mainly classified into AND, OR, XOR, NAND, NOR, INHIBIT, half-adder, and half-subtractor [9,[15][16][17][18]. Owing to the demand for computer miniaturization, Boolean logic systems have been implemented at the molecular levels.…”