Recent Advances in the Design and Sensing Applications of Hemin/Coordination Polymer‐Based Nanocomposites

Alsharabasy, Amir M.; Pandit, Abhay; Farràs, Pau

doi:10.1002/adma.202003883

Cited by 88 publications

(62 citation statements)

References 147 publications

(123 reference statements)

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“…One of the most promising areas for these materials is a woundhealing bandage: biopoylmer-hemin-protein that provides regeneration. The unconditional advantages of hemin are not limited only to its natural origin and biocompatibility with a living organism [51].…”

Section: Introductionmentioning

confidence: 99%

Effect of the Hemin Molecular Complexes on the Structure and Properties of the Composite Electrospun Materials Based on Poly(3-hydroxybutyrate)

et al. 2021

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The creation of innovative fibrous materials based on biodegradable semicrystalline polymers and modifying additives is an urgent scientific problem. In particular, the development of biomedical materials based on molecular complexes and biopolymers with controlled properties is of great interest. The paper suggests an approach to modifying the structure and properties of the composite materials based on poly(3-hydroxybutyrate) (PHB) obtained by the electrospinning method using molecular complexes of hemin. The introduction of 1–5 wt. % of hemin has a significant effect on the supramolecular structure, morphology and properties of PHB-based fibers. Changes in the supramolecular structure intensified with the increasing hemin concentration. On the one hand, a decrease in the fraction of the crystalline phase by 8–10% was observed. At the same time, there is a decrease in the density of the amorphous phase by 15–70%. Moreover, the addition of hemin leads to an improvement in the strength characteristics of the material: the elongation at break increased by 1.5 times, and in the tensile strength, it increased by 3 times. The antimicrobial activity of the hemin-containing composite materials against Escherichia coli and Staphylococcus aureus was confirmed. The obtained materials are proposed to be used in the creation of composite systems for regenerative medicine.

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Section: Introductionmentioning

confidence: 99%

Effect of the Hemin Molecular Complexes on the Structure and Properties of the Composite Electrospun Materials Based on Poly(3-hydroxybutyrate)

et al. 2021

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“…Future work should focus on the following aspects. 1) Designing new ligands or coordination of ligands, the properties of which better satisfy the actual needs, such as molecular structures that mimic the multibiological functions provided by nature ( Alsharabasy et al, 2021 ). Regulating crystal growth while maintaining stability can yield (for example) hierarchical porous features that facilitate mass/electron transfer ( Liu et al, 2020 ).…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Recent Advances in Metal-Organic Framework-Based Electrochemical Biosensing Applications

Li¹,

Zhang²,

Boakye³

et al. 2021

Front. Bioeng. Biotechnol.

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In the face of complex environments, considerable effort has been made to accomplish sensitive, accurate and highly-effective detection of target analytes. Given the versatility of metal clusters and ligands, high porosity and large specific surface area, metal–organic framework (MOF) provides researchers with prospective solutions for the construction of biosensing platforms. Combined with the benefits of electrochemistry method such as fast response, low cost and simple operation, the untapped applications of MOF for biosensors are worthy to be exploited. Therefore, this review briefly summarizes the preparation methods of electroactive MOF, including synthesize with electroactive ligands/metal ions, functionalization of MOF with biomolecules and modification for MOF composites. Moreover, recent biosensing applications are highlighted in terms of small biomolecules, biomacromolecules, and pathogenic cells. We conclude with a discussion of future challenges and prospects in the field. It aims to offer researchers inspiration to address the issues appropriately in further investigations.

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“…Materials containing Hmi can be successfully used for different biomedical applications [ 46 ], including the containers for drug delivery systems [ 47 ] because of their biocompatibility. The most important properties of hemin include the catalytic functions of heme and its oxidized form [ 48 ] and thermal stability [ 49 ]. Owing to the functionality of the porphyrin ring composed of a tetrapyrrole scaffold, Hmi can easily coordinate with many transition metal ions [ 48 ] and its redox properties could be easily controlled [ 50 ].…”

Section: Introductionmentioning

confidence: 99%

“…The most important properties of hemin include the catalytic functions of heme and its oxidized form [ 48 ] and thermal stability [ 49 ]. Owing to the functionality of the porphyrin ring composed of a tetrapyrrole scaffold, Hmi can easily coordinate with many transition metal ions [ 48 ] and its redox properties could be easily controlled [ 50 ].…”

Section: Introductionmentioning

confidence: 99%

The Comparison of Advanced Electrospun Materials Based on Poly(-3-hydroxybutyrate) with Natural and Synthetic Additives

Tyubaeva

Varyan

Кривандин

et al. 2022

JFB

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The comparison of the effect of porphyrins of natural and synthetic origin containing the same metal atom on the structure and properties of the semi-crystalline polymer matrix is of current concern. A large number of modifying additives and biodegradable polymers for biomedical purposes, composed of poly(-3-hydroxybutyrate)-porphyrin, are of particular interest because of the combination of their unique properties. The objective of this work are electrospun fibrous material based on poly(-3-hydroxybutyrate) (PHB), hemin (Hmi), and tetraphenylporphyrin with iron (Fe(TPP)Cl). The structure of these new materials was investigated by methods such as optical and scanning electron microscopy, X-Ray diffraction analysis, Electron paramagnetic resonance method, and Differential scanning calorimetry. The properties of the electrospun materials were analyzed by mechanical and biological tests, and the wetting contact angle was measured. In this work, it was found that even small concentrations of porphyrin can increase the antimicrobial properties by 12 times, improve the physical and mechanical properties by at least 3.5 times, and vary hydrophobicity by at least 5%. At the same time, additives similar in the structure had an oppositely directed effect on the supramolecular structure, the composition of the crystalline, and the amorphous phases. The article considers assumptions about the nature of such differences due to the influence of Hmi and Fe(TPP)Cl) on the macromolecular and fibrous structure of PHB.

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Recent Advances in the Design and Sensing Applications of Hemin/Coordination Polymer‐Based Nanocomposites

Cited by 88 publications

References 147 publications

Effect of the Hemin Molecular Complexes on the Structure and Properties of the Composite Electrospun Materials Based on Poly(3-hydroxybutyrate)

Effect of the Hemin Molecular Complexes on the Structure and Properties of the Composite Electrospun Materials Based on Poly(3-hydroxybutyrate)

Recent Advances in Metal-Organic Framework-Based Electrochemical Biosensing Applications

The Comparison of Advanced Electrospun Materials Based on Poly(-3-hydroxybutyrate) with Natural and Synthetic Additives

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