Recent advances in the development of organic photothermal nano-agents

Abstract

Recently, photothermal therapy (PTT) has attracted tremendous attention because of its high efficacy in tumor ablation and minimal damage to normal tissues. While many inorganic nanomaterials, especially various gold nanostructures and nanocarbons, have been extensively explored for near-infrared (NIR) light triggered PTT in the past decade, a variety of organic photothermal agents have also emerged in recent years, aiming at replacing their inorganic counterparts which usually are not biodegradable. In this mini-review, we will summarize several typical classes of recently developed NIR-absorbing organic PTT nanoagents, which include NIR dye-containing micelles, porphysomes, protein-based agents, conjugated polymers, and organic/inorganic nanocomposites. The development of imaging-guided PTT and combination therapy will be introduced as well. Finally, the perspectives and challenges in the future development of PTT will be discussed.

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“…Comprehensive reviews over these new promising group of biodegradable materials exist in the literature, which readers are encouraged to refer for more detailed information. 282–284 …”

BSA-assisted synthesis of ultrasmall gallic acid–Fe(III) coordination polymer nanoparticles for cancer theranostics

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Highly effective photothermal chemotherapy with pH-responsive polymer-coated drug-loaded melanin-like nanoparticles

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