“…The optimal function of any tissue requires not only each cell acquiring its proper shape, size, and polarity but also attaining a predetermined spatial multicellular organization. Among cell populations, their organization in aligned units has been frequently observed, and this alignment has been shown to be crucial for organ function in tissues such as the corneal stroma, mitral valves, vascular smooth muscle cells, skeletal muscles, tendons, epidermis, and liver (Lynch et al, 2003;Holzapfel et al, 2005;Boote et al, 2011;Bourget et al, 2013;Hoehme et al, 2010;Durst et al, 2015;Le Pabic et al, 2014;Cetera et al, 2017;Tanimizu and Mitaka, 2016).…”