2012
DOI: 10.1016/j.jpba.2012.01.020
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Recent advances in the direct and indirect liquid chromatographic enantioseparation of amino acids and related compounds: A review

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Cited by 102 publications
(46 citation statements)
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“…Among the possible methods, enantioselective high-performance liquid chromatography (HPLC) is routinely used for the discrimination of enantiomers. Chromatographic enantioseparations of β-amino acids have been surveyed in several review articles (Hyun 2005;Ilisz et al 2008Ilisz et al , 2009Ilisz et al , 2012Lämmer-hofer 2010). The direct enantioresolution of β-amino acids has been successfully achieved with both low molecular Abstract Polar-ionic and hydro-organic mobile phase mode of high-performance liquid chromatographic separations of 23 sterically constrained primary β 3 -amino acid enantiomers containing, alkyl, aryl or heteroaryl sidechains were carried out by using newly developed Cinchona alkaloid-based zwitterionic chiral selectors and the stationary phases Chiralpak ZWIX(+)™ and ZWIX(−)™.…”
Section: Introductionmentioning
confidence: 99%
“…Among the possible methods, enantioselective high-performance liquid chromatography (HPLC) is routinely used for the discrimination of enantiomers. Chromatographic enantioseparations of β-amino acids have been surveyed in several review articles (Hyun 2005;Ilisz et al 2008Ilisz et al , 2009Ilisz et al , 2012Lämmer-hofer 2010). The direct enantioresolution of β-amino acids has been successfully achieved with both low molecular Abstract Polar-ionic and hydro-organic mobile phase mode of high-performance liquid chromatographic separations of 23 sterically constrained primary β 3 -amino acid enantiomers containing, alkyl, aryl or heteroaryl sidechains were carried out by using newly developed Cinchona alkaloid-based zwitterionic chiral selectors and the stationary phases Chiralpak ZWIX(+)™ and ZWIX(−)™.…”
Section: Introductionmentioning
confidence: 99%
“…Since most biologically important compounds exist in two enantiomeric forms that can possess differences in their physiological activity, the impetus for the separation of optical isomers and the preparation of enantiomerically pure compounds in the field of biotechnology, chemistry and pharmacology is still increasing (ILISZ et al, 2012). Chromatographic methods, i.e.…”
Section: Introductionmentioning
confidence: 99%
“…The separation of enantiomers of unusual β-amino acids by high-performance liquid chromatography (HPLC) has been comprehensively investigated, and the results have been documented in several review papers (Ilisz et al, 2008(Ilisz et al, , 2010(Ilisz et al, , 2012a(Ilisz et al, , 2012b(Ilisz et al, , 2012c(Ilisz et al, , 2013. However, data relating to the HPLC analyses of fluorinated amino acids are very scarce, especially in the case of enantioseparation.…”
Section: Introductionmentioning
confidence: 99%