2019
DOI: 10.3390/molecules24081541
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Recent Advances in the Discovery and Biosynthetic Study of Eukaryotic RiPP Natural Products

Abstract: Natural products have played indispensable roles in drug development and biomedical research. Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a group of fast-expanding natural products attribute to genome mining efforts in recent years. Most RiPP natural products were discovered from bacteria, yet many eukaryotic cyclic peptides turned out to be of RiPP origin. This review article presents recent advances in the discovery of eukaryotic RiPP natural products, the elucidation of th… Show more

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Cited by 27 publications
(29 citation statements)
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“…The genes encoding for the biosynthetic enzymes for SMs are often arranged in individual clusters named biosynthetic gene cluster (BGC), regardless of the class of SM [1]. This organization of clusters is also given for the previously described fungal RiPPs ustiloxins, phomopsins, amatoxins, phallotoxins, borosins and asperipins [7]. This clustered organization is one important feature for the in silico identification of BGCs.…”
Section: Introductionmentioning
confidence: 98%
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“…The genes encoding for the biosynthetic enzymes for SMs are often arranged in individual clusters named biosynthetic gene cluster (BGC), regardless of the class of SM [1]. This organization of clusters is also given for the previously described fungal RiPPs ustiloxins, phomopsins, amatoxins, phallotoxins, borosins and asperipins [7]. This clustered organization is one important feature for the in silico identification of BGCs.…”
Section: Introductionmentioning
confidence: 98%
“…RiPPs are a rapid growing group of natural products that can be classified in more than 20 different compound classes. Please refer to the reviews by Arnison, P. G. et al and Luo, S. & Dong, S. H [6,7]. Small peptides are of increasing interest due to unique bioactive properties aiming at "undruggable" diseases and successfully eradicating anti-biotic resistant microorganisms [8].…”
Section: Introductionmentioning
confidence: 99%
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“…Studied were also the effect of enzymolysis on the performance of soy protein-based adhesive [8] and the study of new octadecanoid enantiomers from the whole plants of Plantago depressa [9]. Connected studies that combined the biological properties of another type of secondary metabolite described the biosynthesis of fluorescent β subunits of C-phycocyanin from Spirulina subsalsa in Escherichia coli, and their antioxidant properties [10] and presented the synthesis of the sex pheromone of the tea tussock moth based on a resource chemistry strategy [11].Review articles described well the synthesis and anticancer activity of CDDO and CDDO-Me, two derivatives of natural triterpenoids [12], the advances in biosynthesis, pharmacology, and pharmacokinetics of pinocembrin, a promising natural small-molecule drug [13], as well as recent advances in the discovery and biosynthetic study of eukaryotic RiPP natural products [14]. Another review article addressed the issue of whether polyphenols could help in the control of rheumatoid arthritis [15].Summing up, the current development in the chemistry of natural products proved to be so exciting that now Molecules itself organized recently several special issues oriented to this unfinished…”
mentioning
confidence: 99%
“…Review articles described well the synthesis and anticancer activity of CDDO and CDDO-Me, two derivatives of natural triterpenoids [12], the advances in biosynthesis, pharmacology, and pharmacokinetics of pinocembrin, a promising natural small-molecule drug [13], as well as recent advances in the discovery and biosynthetic study of eukaryotic RiPP natural products [14]. Another review article addressed the issue of whether polyphenols could help in the control of rheumatoid arthritis [15].…”
mentioning
confidence: 99%