Recent Advances in the Field of Amino Acid-Conjugated Aminoferrocenes—A Personal Perspective
Mojca Čakić Semenčić,
Monika Kovačević,
Lidija Barišić
Abstract:The development of turn-based inhibitors of protein–protein interactions has attracted considerable attention in medicinal chemistry. Our group has synthesized a series of peptides derived from an amino-functionalized ferrocene to investigate their potential to mimic protein turn structures. Detailed DFT and spectroscopic studies (IR, NMR, CD) have shown that, for peptides, the backbone chirality and bulkiness of the amino acid side chains determine the hydrogen-bond pattern, allowing tuning of the size of the… Show more
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